Micro-Drops and Digital Microfluidics

2nd Edition

Authors: Jean Berthier
Hardcover ISBN: 9781455725502
eBook ISBN: 9781455728008
Imprint: William Andrew
Published Date: 13th December 2012
Page Count: 560
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Table of Contents



Chapter 1. Introduction: Digital Microfluidics in Today’s Microfluidics

1.1 The development of microfluidics

1.2 The advantages of digital and droplet microfluidics compared to conventional microflows

1.3 The respective place of digital and droplet microfluidics in today’s microfluidics

1.4 Summary


Chapter 2. Theory of Wetting

2.1 Introduction

2.2 Interfaces and surface tension

2.3 Laplace’s law and applications

2.4 Wetting—partial or total wetting

2.5 Contact angle—Young’s law

2.6 Work of adhesion, work of cohesion, and the Young–Dupré’s equation

2.7 Capillary force, force on a triple line

2.8 Measuring surface tension of liquids

2.9 Surface tension of solids

2.10 Minimization of the surface energy and minimal energy surface

2.11 Summary


Chapter 3. The Physics of Droplets

3.1 Introduction

3.2 The shape of microdrops

3.3 Drops on inhomogeneous surfaces

3.4 Drops moving by capillarity

3.5 Contact angle hysteresis

3.6 Droplet pinning

3.7 The effect of surfactants

3.8 Marangoni convection

3.9 Evaporation

3.10 Summary


Chapter 4. Electrowetting Theory

4.1 Introduction

4.2 Theoretical background

4.3 Lippmann–Young’s law and the electrocapillary equivalence

4.4 Saturation

4.5 Hysteresis

4.6 Working range of EWOD devices

4.7 Materials and substrates

4.8 Discussion: special substrates and new concepts

4.9 Summary


Chapter 5. EWOD Microsystems

5.1 Introduction

5.2 Open and covered EWOD microsystems

5.3 Droplet motion

5.4 Division of droplets

5.5 Droplet mergi


In this 2nd edition of Micro-Drops and Digital Microfluidics, Jean Berthier explores the fundamentals and applications of digital microfluidics, enabling engineers and scientists to design this important enabling technology into devices and harness the considerable potential of digital microfluidics in testing and data collection.

This book describes the most recent developments in digital microfluidics, with a specific focus on the computational, theoretical and experimental study of microdrops.

Unique in its emphasis on digital microfluidics and with diverse applications ranging from drug delivery to point-of-care diagnostic chips, organic synthesis to microreactors, Micro-Drops and Digital Microfluidics meets the needs of audiences across the fields of bioengineering and biotechnology, and electrical and chemical engineering.

Key Features

  • Authoritative reporting on the latest changes in microfluidic science, where microscopic liquid volumes are handled as ""microdrops"" and separately from ""nanodrops."
  • A methodical examination of how liquid microdrops behave in the complex geometries of modern miniaturized systems and interact with different morphological (micro-fabricated, textured) solid substrates
  • A thorough explanation of how capillary forces act on liquid interfaces in contact with micro-fabricated surfaces
  • Analysis of how droplets can be manipulated, handled, or transported using electric fields (electrowetting), acoustic actuation (surface acoustic waves), or by a carrier liquid (microflow)
  • A fresh perspective on the future of microfluidics


Engineers, scientists, and developers in biotechnology, nanotechnology, MEMS, and pharmaceuticals. This book will also be an excellent text for a Masters level course in physics and biotechnology


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© William Andrew 2013
William Andrew
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About the Authors

Jean Berthier Author

Affiliations and Expertise

CEA/LETI (Laboratory of Electronics, Technology and Information), Grenoble, France