Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms

Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms

1st Edition - August 14, 2021

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  • Editors: Xinyu Liu, Yu Sun
  • Paperback ISBN: 9780128239902
  • eBook ISBN: 9780128242438

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Description

Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms provides a comprehensive introduction to the state-of-the-art micro and nano systems that have recently been developed and applied to biophysical studies of cells and small organisms. These micro and nano systems span from microelectromechanical systems (MEMS) and microfluidic devices to robotic micro-nanomanipulation systems. These biophysical studies range from cell mechanics to the neural science of worms and Drosophila. This book will help readers understand the fundamentals surrounding the development of these tools and teach them the most recent advances in cellular and organismal biophysics enabled by these technologies.

Key Features

  • Comprehensive coverage of micro and nano-system technology and application to biophysical studies of cells and small organisms.
  • Highlights the most recent advances in cellular and organismal biophysics enabled by micro and nano systems.
  • Insightful outlook on future directions and trends in each chapter covering a sub-area of the book topic.

Readership

Researchers and graduate students in disciplines of biomedical engineering, mechanical engineering, electrical engineering, biological, physics and biology, who are interested in learning the state-of-the-art technologies on micro and nano systems for studying biophysics of biological cells and small organisms. University instructors of graduate level courses in disciplines of biological and biomedical engineering, mechanical engineering, electrical engineering, and physics. Industrial practitioners (job role: R&D scientist, engineer, and manager) in sectors such as microelectromechanical systems (MEMS), nanotechnology, biotechnology, and medical devices.

Table of Contents

  • 1. Micro systems for probing cellular forces and cellular mechanical properties
    2. Force-sensing micropillar arrays for cell mechanics and mechanobiology
    3. Vertical nanostructures for probing live cells
    4. Probing tissue mechanics at the cellular length-scale in cancer microenvironments
    5. Advanced microfluidic devices for cell electroporation and manipulation
    6. High-throughput three-dimensional cellular platforms for screening biophysical microenvironmental signals
    7. Acoustofluidic technology for cell biophysics
    8. Microfluidic devices for neutrophil migration studies
    9. Field-controlled micro-nano manipulations and micro-nano robots
    10. Robotic optical tweezers for cell biophysics
    11. Robotic and microfluidic systems for single cell injection
    12. Biophysical phenotyping of C. elegans in a microfluidic chip for high-throughput drug screening
    13. Microfluidic devices for imaging and manipulation of C. elegans
    14. Micro systems for the study of behavioral responses of C. elegans
    to various physical and chemical stimuli
    15. Microfluidic devices to study the effect of electric fields on C. elegans and Danio rerio
    16. Force-controlled robotic systems for mechanical stimulation of Drosophila larvae

Product details

  • No. of pages: 404
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: August 14, 2021
  • Imprint: Academic Press
  • Paperback ISBN: 9780128239902
  • eBook ISBN: 9780128242438

About the Editors

Xinyu Liu

Xinyu Liu is the Percy Edward Hart Professor of Mechanical and Industrial Engineering at the University of Toronto. Prior to joining the University of Toronto, he was an Associate Professor and the Canada Research Chair in Microfluidics and BioMEMS in the Department of Mechanical Engineering at McGill University. His research focuses on microfluidics, bioMEMS, and soft and micro robotics, with applications primarily in medicine and biology. He received the Canadian Rising Star in Global Health Award, the Douglas R. Colton Metal for Research Excellence, the McGill Christophe Pierre Award for Research Excellence, the MINE Outstanding Young Researcher Award, and seven best paper awards at major engineering and biomedical conferences. He is a fellow of the American Society of Mechanical Engineers.

Affiliations and Expertise

Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada

Yu Sun

Yu Sun is a Professor in the Department of Mechanical and Industrial Engineering, with joint appointments in the Institute of Biomaterials and Biomedical Engineering, the Department of Electrical and Computer Engineering, and the Department of Computer Science at the University of Toronto (UofT), in Canada. He is a Tier I Canada Research Chair, and the founding Director of the UofT Robotics Institute. His Advanced Micro and Nanosystems Laboratory specializes in developing innovative technologies and instruments for manipulating and characterizing cells, molecules, and nanomaterials. Prof. Sun was elected Fellow of ASME (American Society of Mechanical Engineers), IEEE (Institute of Electrical and Electronics Engineers), AAAS (American Association for the Advancement of Science), NAI (US National Academy of Inventors), AIMBE (American Institute of Medical and Biological Engineering), CAE (Canadian Academy of Engineering), and RSC (Royal Society of Canada) for his work on micro-nano devices and robotic systems.

Affiliations and Expertise

Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada

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