Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms

Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms is the first book providing a comprehensive introduction to the state-of-the-art micro and nano systems that have recently been developed and applied to biophysical studies of cells and small organisms. These micro and nano systems span from microelectromechanical systems (MEMS) and microfluidic devices to robotic micro-nanomanipulation systems. The biophysical studies range from cell mechanics to neural science of worms and Drosophila. This book helps readers to understand the fundamentals in the development of these tools and learn the most recent advances in cellular and organismal biophysics enabled by these technologies.

• Comprehensive coverage of micro and nano-system technology and application to biophysical studies of cells and small organisms
• Highlights the most recent advances in cellular and organismal biophysics enabled by micro and nano systems
• Insightful outlook on future directions and trends in each chapter covering a sub-area of the book topic

Researchers and graduate students in disciplines of biomedical engineering, mechanical engineering, electrical engineering, biological, physics and biology, who are interested in learning the state-of-the-art technologies on micro and nano systems for studying biophysics of biological cells and small organisms. University instructors of graduate level courses in disciplines of biological and biomedical engineering, mechanical engineering, electrical engineering, and physics. Industrial practitioners (job role: R&D scientist, engineer, and manager) in sectors such as microelectromechanical systems (MEMS), nanotechnology, biotechnology, and medical devices

1. Microsystems for probing cellular forces and cellular mechanical properties
2. Force-sensing micropillar arrays for cell mechanics studies
3. Nanopillars/nanoneedles for probing live cells
4. Probing tissue mechanics at the cellular length-scale in cancer microenvironments
5. Microfluidic devices/systems for high-throughput cell manipulation and electroporation
6. High throughput 3D cellular platforms for screening biophysical microenvironmental signals
7. Acoustofluidic devices for cell biophysics
8. Microfluidic devices for neutrophil mitigation studies
9. Microrobots for cell biophysics
10. Robotic optical tweezers for cell biophysics
11. Robotic and microfluidic systems for single-cell microinjection
12. Biophysical phenotyping of C. elegans in a microfluidic chip for high-throughput drug screening
13. Microfluidic devices for immobilization, imaging, and high-throughput sorting of C. elegans
14. Microsystems for the study of thermotactic behavior of C. elegans
15. Microfluidics devices to study the effect of electric field on C. elegans and Danio rerio
16. Robotic micromanipulation systems for mechanical stimulation of Drosophila larvae