Description

Self-assembled nanostructures based on peptides and proteins have been investigated and presented as biomaterials with an impressive potential for a broad range of applications such as microfabrication, biosensing platforms, drug delivery systems, bioelectronics and tissue reparation. Through self-assembly peptides can give rise to a range of well-defined nanostructures such as nanotubes, nanofibers, nanoparticles, nanotapes, gels and nanorods. However, there are challenges when trying to integrate these biological nanostructures in the development of sensing devices or drug-delivery systems – challenges such as controlling the size during synthesis, the stability in liquid environments and manipulation.

In "Micro and Nanofabrication Using Self-assembled Biological Nanostructures" the options and challenges when using self-assembled peptide nanostructures in micro and nanofabrication are discussed. The publication covers different ways to manipulate, deposit and immobilize on specific locations these biological nanostructures in order to use them in the fabrication of new structures or as part of biosensing platforms. Examples where researchers used biological nanostructures for those types of applications are provided. Finally, future applications are discussed as well as parameters to accelerate and expand the use of these biological building blocks in nano- and micro-fabrication processes by taking advantage of their impressive properties such as low-cost and short synthesis time.

Readership

Engineers and scientist working with biological materials or in biomedical or chemical engineering or in biochemistry; scientists doing research in the areas of biomaterials, cell handling, bionanotechnology, drug delivery, tissue engineering, regenerative medicine; nanotechnology students

Table of Contents

  • Contributors
  • Preface
  • Chapter 1: Self-Assembled Biological Nanofibers for Biosensor Applications
    • Abstract
    • 1.1. Introduction
    • 1.2. Types of self-assembled biological nanofibers
    • 1.3. Practical laboratory considerations
    • 1.4. Functionalization approaches
    • 1.5. Common challenges in biosensor platforms
    • 1.6. Conclusions
  • Chapter 2: Fabrication of Nanostructures Using Self-Assembled Peptides as Templates: The Diphenylalanine Case
    • Abstract
    • 2.1. Introduction
    • 2.2. Diphenylalanine peptide
    • 2.3. Fabrication of new nanostructures using diphenylalanine nanostructures as a template
    • 2.4. Conclusions
  • Chapter 3: Self-Assembled Peptide Nanostructures for the Fabrication of Cell Scaffolds
    • Abstract
    • 3.1. Introduction
    • 3.2. Classes of self-assembled peptide scaffolds
    • 3.3. Natural self-assembling peptide systems
    • 3.4. Semisynthetic self-assembling peptide systems
    • 3.5. Fabrication and control of mechanical properties of peptide scaffolds
    • 3.6. The in vitro and in vivo applications of self-assembly peptide scaffolds
    • 3.7. Biofunctionalization of peptide hydrogels
    • 3.8. SAP scaffolds as a support for 3D cell culture
    • 3.9. Utilizing self-assembly peptide scaffold as cell therapy in vivo
    • 3.10. Future perspectives
  • Chapter 4: Self-Assembled Peptide Nanostructures for Regenerative Medicine and Biology
    • Abstract
    • 4.1. Introduction
    • 4.2. Peptide building blocks constructing nanostructures
    • 4.3. Cell adhesion
    • 4.4. Tissue engineering
    • 4.5. Peptide hydrogels as vehicles for controlled drug delivery
    • 4.6. Peptide therapeutics
    • 4.7. Conclusion
    • Acknowledgment

Details

No. of pages:
126
Language:
English
Copyright:
© 2015
Published:
Imprint:
William Andrew
Print ISBN:
9780323296427
Electronic ISBN:
9780323296526

About the editors

Jaime Castillo-León

Senior researcher, DTU Nanotech, Technical University of Denmark

Winnie Svendsen

Associate Professor, DTU Nanotech, Technical University of Denmark