Methods of Animal Experimentation

Methods of Animal Experimentation

Volume III

1st Edition - January 1, 1968

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  • Editor: William I. Gay
  • eBook ISBN: 9781483259840

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Methods of Animal Experimentation, Volume III, compiles methods of animal experimentation in a variety of fields so that the researcher might have a reference that would allow him to incorporate other techniques in his research studies. The methods described represent only the most efficient ways known to date for using animals to gain research information. They are not, however, ""standard methods"" for research in which each experiment seeks or confirms new information by another means. The largest portion of this volume is devoted to behavioral science because of the growing importance of this field in two respects. First, it is an important consideration in all experiments in which animals are used repeatedly. Second, the use of higher animals in comparative behavioral research offers much toward the solution of disease problems of man related to behavior and perhaps even clues to his social interactions. A chapter by an author with extensive experiences with dolphins helps us judge how this animal may be used, and warns of the many problems incurred in research using any of the marine mammals. Other chapters cover dental research on animals, fetal surgery and physiological measurements in very young animals, and microsurgery.

Table of Contents

  • List of Contributors


    Contents of Previous Volumes

    Chapter 1 bUse of Rodents in Behavioral Research

    I. Introduction

    II. The Physical Environment

    III. Basic Concepts

    IV. Preexperimental Preparations

    V. Behavioral Control


    Chapter 2 Use of the Dog in Behavioral Research

    I. Introduction

    II. General Procedures in Dog Testing

    III. Specific Tests and Observations

    IV. Conditioning Procedures

    V. Spontaneous Behavioral Abnormalities in Dogs


    General References

    Chapter 3 Use of Primates as Behavioral Research Subjects

    I. Introduction

    II. Response Classification

    III. Experimental Problems Often Studied

    IV. Apparatus and Concepts of Equipment Use

    V. Maintenance of Primates for Behavioral Studies


    Chapter 4 Use of Cats in Behavioral Research

    I. Introduction

    II. Behavioral Development

    III. Comparative Studies

    IV. Assessment Studies

    V. Conclusions


    Chapter 5 Microsurgery

    I. Introduction

    II. Equipment for Microsurgery

    III. Principles of Microsuture Techniques and Other Manipulations

    IV. Microsurgery of Vessels Supplying Extremities, Brain, Heart, and Other Organs

    V. Microsurgery of Nerves

    VI. Microtechniques in Ophthalmology

    VII. Microtechniques in Otology and Laryngology

    VIII. Microtechniques in Surgery and Gynecology

    IX. Microtechniques in Neurosurgery and Experimental Neurology

    X. Clinical Application, Transplantation of Organs, and General Aspects of Further Development


    Chapter 6 Experimental Procedures and Surgical Techniques Performed on Intrauterine Fetal Animals

    I. Introduction

    II. Preparation of the Pregnant Animal

    III. Closed Abdominal Preparation

    IV. Closed Uterine Preparation

    V. Closed Fetal Membrane Preparation

    VI. Uterine Window Preparation

    VII. Modified Uterine Window Preparation

    VIII. Exteriorization of the Fetus

    IX. Thymectomy

    X. Catheterization Techniques

    XI. Splenectomy


    Chapter 7 Physiological Measurements in Neonatal Animals

    I. Introduction

    II. General Considerations

    III. Removal of Nervous and Other Tissues

    IV. Electrophysiological Measurements from the Developing Brain

    V. Anesthetic

    VI. Implantation of Electrodies for Physiological Recordings

    VII. Postoperative Care

    VIII. Conditions for Recording

    IX. Administration of Drugs

    X. Special Considerations for Studies of Fetal Animals


    Chapter 8 The Use of Animals in Dental Research

    I. Introduction

    II. Characteristics of Various Animal Species

    III. Housing and Management

    IV. Dental Diseases

    V. Transplantation, Replantation, and Implantation


    Chapter 9 Methods of Using Fish as Biological Research Subjects

    I. Introduction

    II. Maintaining Fish in the Laboratory

    III. Anesthesia

    IV. Surgical Manipulations

    V. Blood and Vascular Function

    VI. Renal Function

    VII. Locomotor Function

    VIII. Gill Function

    IX. Gastrointestinal Functions

    X. Neurosensory Functions

    XI. Hormone Function


    Chapter 10 The Bottlenosed Dolphin in Biomedical Research

    I. Introduction

    II. Anatomy

    III. Senses

    IV. Physiology

    V. Clinical Procedures

    VI. Behavior and Husbandry

    VII. Disease Problems and Therapeutics

    VIII. Clinical Observation of Behavior

    IX. Scope and Limitations of Tursiops in Biomedical Experimentation


    Author Index

    Subject Index

Product details

  • No. of pages: 484
  • Language: English
  • Copyright: © Academic Press 1968
  • Published: January 1, 1968
  • Imprint: Academic Press
  • eBook ISBN: 9781483259840

About the Editor

William I. Gay

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