Methods of Animal Experimentation

Volume III

1st Edition - January 1, 1968
Editor: William I. Gay
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 2 - 5 9 8 4 - 0

Methods of Animal Experimentation, Volume III, compiles methods of animal experimentation in a variety of fields so that the researcher might have a reference that would allow him… Read more

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Methods of Animal Experimentation, Volume III, compiles methods of animal experimentation in a variety of fields so that the researcher might have a reference that would allow him to incorporate other techniques in his research studies. The methods described represent only the most efficient ways known to date for using animals to gain research information. They are not, however, ""standard methods"" for research in which each experiment seeks or confirms new information by another means. The largest portion of this volume is devoted to behavioral science because of the growing importance of this field in two respects. First, it is an important consideration in all experiments in which animals are used repeatedly. Second, the use of higher animals in comparative behavioral research offers much toward the solution of disease problems of man related to behavior and perhaps even clues to his social interactions. A chapter by an author with extensive experiences with dolphins helps us judge how this animal may be used, and warns of the many problems incurred in research using any of the marine mammals. Other chapters cover dental research on animals, fetal surgery and physiological measurements in very young animals, and microsurgery.

List of Contributors

Preface

Contents of Previous Volumes

Chapter 1 bUse of Rodents in Behavioral Research

I. Introduction

II. The Physical Environment

III. Basic Concepts

IV. Preexperimental Preparations

V. Behavioral Control

References

Chapter 2 Use of the Dog in Behavioral Research

I. Introduction

II. General Procedures in Dog Testing

III. Specific Tests and Observations

IV. Conditioning Procedures

V. Spontaneous Behavioral Abnormalities in Dogs

References

General References

Chapter 3 Use of Primates as Behavioral Research Subjects

I. Introduction

II. Response Classification

III. Experimental Problems Often Studied

IV. Apparatus and Concepts of Equipment Use

V. Maintenance of Primates for Behavioral Studies

References

Chapter 4 Use of Cats in Behavioral Research

I. Introduction

II. Behavioral Development

III. Comparative Studies

IV. Assessment Studies

V. Conclusions

References

Chapter 5 Microsurgery

I. Introduction

II. Equipment for Microsurgery

III. Principles of Microsuture Techniques and Other Manipulations

IV. Microsurgery of Vessels Supplying Extremities, Brain, Heart, and Other Organs

V. Microsurgery of Nerves

VI. Microtechniques in Ophthalmology

VII. Microtechniques in Otology and Laryngology

VIII. Microtechniques in Surgery and Gynecology

IX. Microtechniques in Neurosurgery and Experimental Neurology

X. Clinical Application, Transplantation of Organs, and General Aspects of Further Development

References

Chapter 6 Experimental Procedures and Surgical Techniques Performed on Intrauterine Fetal Animals

I. Introduction

II. Preparation of the Pregnant Animal

III. Closed Abdominal Preparation

IV. Closed Uterine Preparation

V. Closed Fetal Membrane Preparation

VI. Uterine Window Preparation

VII. Modified Uterine Window Preparation

VIII. Exteriorization of the Fetus

IX. Thymectomy

X. Catheterization Techniques

XI. Splenectomy

References

Chapter 7 Physiological Measurements in Neonatal Animals

I. Introduction

II. General Considerations

III. Removal of Nervous and Other Tissues

IV. Electrophysiological Measurements from the Developing Brain

V. Anesthetic

VI. Implantation of Electrodies for Physiological Recordings

VII. Postoperative Care

VIII. Conditions for Recording

IX. Administration of Drugs

X. Special Considerations for Studies of Fetal Animals

References

Chapter 8 The Use of Animals in Dental Research

I. Introduction

II. Characteristics of Various Animal Species

III. Housing and Management

IV. Dental Diseases

V. Transplantation, Replantation, and Implantation

References

Chapter 9 Methods of Using Fish as Biological Research Subjects

I. Introduction

II. Maintaining Fish in the Laboratory

III. Anesthesia

IV. Surgical Manipulations

V. Blood and Vascular Function

VI. Renal Function

VII. Locomotor Function

VIII. Gill Function

IX. Gastrointestinal Functions

X. Neurosensory Functions

XI. Hormone Function

References

Chapter 10 The Bottlenosed Dolphin in Biomedical Research

I. Introduction

II. Anatomy

III. Senses

IV. Physiology

V. Clinical Procedures

VI. Behavior and Husbandry

VII. Disease Problems and Therapeutics

VIII. Clinical Observation of Behavior

IX. Scope and Limitations of Tursiops in Biomedical Experimentation

References

Author Index

Subject Index