Methods in Biomedical Informatics

Methods in Biomedical Informatics

A Pragmatic Approach

1st Edition - September 3, 2013

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  • Editor: Neil Sarkar
  • eBook ISBN: 9780124016842
  • Hardcover ISBN: 9780124016781

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Description

Beginning with a survey of fundamental concepts associated with data integration, knowledge representation, and hypothesis generation from heterogeneous data sets, Methods in Biomedical Informatics provides a practical survey of methodologies used in biological, clinical, and public health contexts. These concepts provide the foundation for more advanced topics like information retrieval, natural language processing, Bayesian modeling, and learning classifier systems. The survey of topics then concludes with an exposition of essential methods associated with engineering, personalized medicine, and linking of genomic and clinical data. Within an overall context of the scientific method, Methods in Biomedical Informatics provides a practical coverage of topics that is specifically designed for: (1) domain experts seeking an understanding of biomedical informatics approaches for addressing specific methodological needs; or (2) biomedical informaticians seeking an approachable overview of methodologies that can be used in scenarios germane to biomedical research.

Key Features

  • Contributors represent leading biomedical informatics experts: individuals who have demonstrated effective use of biomedical informatics methodologies in the real-world, high-quality biomedical applications
  • Material is presented as a balance between foundational coverage of core topics in biomedical informatics with practical "in-the-trenches" scenarios.
  • Contains appendices that function as primers on: (1) Unix; (2) Ruby; (3) Databases; and (4) Web Services.

Readership

Biomedical informaticians seeking methods that can be used in on-going research, and biological and medical practitioners seeking biomedical informatics approaches to address specific needs.

Table of Contents

  • Contributors

    Chapter 1. Introduction

    Abstract

    1.1 Biomedical Informatics and its Applications

    1.2 The Scientific Method

    1.3 Data, Information, Knowledge, and Wisdom

    1.4 Overview of Chapters

    1.5 Expectations and Challenge to the Reader

    References

    Chapter 2. Data Integration: An Overview

    Abstract

    2.1 Objectives of Integration

    2.2 Integration Approaches: Overview

    2.3 Database Basics

    2.4 Physical vs. Logical Integration: Pros and Cons

    2.5 Prerequisite Subtasks

    2.6 Data Transformation and Restructuring

    2.7 Integration Efforts in Biomedical Research

    2.8 Implementation Tips

    2.9 Conclusion: Final Warnings

    References

    Chapter 3. Knowledge Representation

    Abstract

    3.1 Knowledge and Knowledge Representation

    3.2 Procedural VS. Declarative Representations

    3.3 Representing Knowledge Declaratively

    3.4 What Does a Representation Mean?

    3.5 Building Knowledge Bases in Practice

    3.6 Summary

    References

    Chapter 4. Hypothesis Generation from Heterogeneous Datasets

    Abstract

    Acknowledgments

    4.1 Introduction

    4.2 Preliminary Background

    4.3 Description of Methods

    4.4 Applications in Medicine and Public Health

    4.5 Summary

    References

    Chapter 5. Geometric Representations in Biomedical Informatics: Applications in Automated Text Analysis

    Abstract

    5.1 Introduction

    5.2 The Nature of Geometric Representations

    5.3 Dimension Reduction

    5.4 Classification

    5.5 Beyond Distance

    5.6 Building Geometric Models with the Semantic Vectors Package

    5.7 Summary and Conclusion

    References

    Chapter 6. Biomedical Natural Language Processing and Text Mining

    Abstract

    Acknowledgments

    6.1 Natural Language Processing and Text Mining Defined

    6.2 Natural Language

    6.3 Approaches to Natural Language Processing and Text Mining

    6.4 Some Special Considerations of Natural Language Processing in the Biomedical Domain

    6.5 Building Blocks of Natural Language Processing Applications

    6.6 Additional Components of Natural Language Processing Applications

    6.7 Evaluation in Natural Language Processing

    6.8 Practical Applications: Text Mining Tasks

    6.9 Software Engineering in Natural Language Processing

    6.10 Conclusion

    References

    Chapter 7. Knowledge Discovery in Biomedical Data: Theory and Methods

    Abstract

    7.1 Introduction

    7.2 Knowledge Discovery as a Process: Data Mining in Perspective

    7.3 A Brief Overview of Machine Learning

    7.4 A Knowledge Discovery Life Cycle

    7.5 Ethical Issues

    7.6 Summary

    7.7 Additional Resources

    References

    Chapter 8. Bayesian Methods in Biomedical Data Analysis

    Abstract

    8.1 Introduction

    8.2 Fundamentals of Bayesian Methods

    8.3 Bayesian Network Analysis

    8.4 Biomedical Applications

    8.5 Summary

    References

    Chapter 9. Learning Classifier Systems: The Rise of Genetics-Based Machine Learning in Biomedical Data Mining

    Abstract

    9.1 Introduction

    9.2 Learning Classifier Systems

    9.3 Facing the Challenges

    9.4 Rise of the Machines

    References

    Chapter 10. Engineering Principles in Biomedical Informatics

    Abstract

    10.1 Introduction

    10.2 Building Innovative Products: Implications for Biomedical Informatics

    10.3 Modeling Information Flows for Software Engineering: The Unified Modeling Language

    10.4 UML Applications in Biomedical Informatics

    10.5 From Modeling to Simulation: Careflow Representation, Simulation, and Learning

    10.6 Engineering Principles and Ideas in Biomedical Data Mining

    10.7 Building and Evaluating Data Mining Models

    10.8 Discussion

    10.9 Conclusions

    References

    Chapter 11. Biomedical Informatics Methods for Personalized Medicine and Participatory Health

    Abstract

    11.1 Introduction to Personalized Medicine

    11.2 Data Sources for Personalized Medicine

    11.3 Data Analysis for Personalized Medicine

    11.4 Introduction to Participatory Health

    11.5 Data Collection for Participatory Health

    11.6 Data Exchange and Use in Participatory Health

    11.7 Conclusions and Future Directions

    References

    Chapter 12. Linking Genomic and Clinical Data for Discovery and Personalized Care

    Abstract

    12.1 Introduction

    12.2 Repurposing EHRs for Clinical and Translational Research

    12.3 Phenotyping Algorithms: Finding Meaningful Populations of Patients from EHR Data

    12.4 Types of Genetic Association Studies

    12.5 Moving to the Bedside: Implementing Genetics into the EHR

    12.6 Summary

    12.7 Selected Websites of Interest

    References

    Further reading

    Chapter 13. Putting Theory into Practice

    Abstract

    13.1 Entering the Era of Big Data

    13.2 Prospective Applicability of Biomedical Informatics Methodologies

    13.3 A Final Challenge to the Reader

    References

    Appendix A. Unix Primer

    A.1 Unix File System

    A.2 Unix Shell

    A.3 Unix Command Syntax

    A.4 Basic Commands

    A.5 Traversing Directories and Files

    A.6 Working with Directories and Files

    A.7 Input and Output

    A.8 Basic Data Analysis

    A.9 Access Permissions

    A.10 Text Editors

    A.11 Summary of Commands

    References and Resources

    History

    Commands

    Text Editors

    Appendix B. Ruby Primer

    B.1 Hello World

    B.2 Extensions to Hello World

    B.3 Numbers and Math

    B.4 Strings

    B.5 Conditional Statements and Control Structures

    B.6 Directories and Files

    B.7 Regular Expressions

    B.8 Arrays and Hashes

    B.9 Interactive Ruby (irb)

    B.10 Ruby Gems

    References and Resources

    Books and Articles

    Web Resources and Tutorials

    Appendix C. Database Primer

    C.1 Example PubMed/MEDLINE Database

    C.2 Working in the MySQL Environment

    C.3 Creating, Accessing, and Deleting a Database

    C.4 Creating, Modifying, and Deleting Tables

    C.5 Loading Data into Tables

    C.6 Retrieving Data from Tables

    C.7 Joining Multiple Tables

    C.8 Automating MySQL Queries

    References and Resources

    Articles

    Web Resources and Tutorials

    Appendix D. Web Services

    D.1 NCBI E-utilities

    D.2 NCBO Annotator

    References and Resources

    Book and Articles

    Web Resources and Tutorials

    Index

    Subject Index

Product details

  • No. of pages: 592
  • Language: English
  • Copyright: © Academic Press 2013
  • Published: September 3, 2013
  • Imprint: Academic Press
  • eBook ISBN: 9780124016842
  • Hardcover ISBN: 9780124016781

About the Editor

Neil Sarkar

Affiliations and Expertise

Director of Biomedical Informatics and Assistant Professor in Microbiology and Molecular Genetics (with a Secondary Appointment in Computer Science) at the University of Vermont, Burlington, Vermont.

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