Metal Transporters

Metal Transporters

1st Edition - October 5, 2012

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  • Editors: Jose Arguello, Svetlana Lutsenko
  • eBook ISBN: 9780123946102
  • Hardcover ISBN: 9780123943903

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This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others.

Key Features

  • Field is cutting-edge and a lot of the information is new to research community
  • Wide breadth of topic coverage
  • Contributors of high renown and expertise


Researchers in biochemistry, molecular and cellular biology

Table of Contents

  • Series Editors



    The Blossoming Field of Metal Transport Enters the Era of Mechanistic Research

    Previous Volumes in Series

    Chapter One Transferrin-Mediated Cellular Iron Delivery

    1 Iron

    2 Iron Homeostasis

    3 Transferrin

    4 The TFR

    5 Recombinant Expression

    6 Kinetics of Iron Release

    7 Structure of the hTF/TFR Complex

    Chapter Two Structure, Function and Binding Selectivity and Stereoselectivity of Siderophore–Iron Outer Membrane Transporters

    1 Introduction

    2 Siderophores

    3 Structure of Siderophore–Iron TBDTs

    4 Binding Sites of Siderophore–Iron TBDTs

    5 Siderophore–Iron Transport by TBDTs

    6 TBDT are Involved in Signaling Cascades

    7 Conclusion

    Chapter Three Iron Transport Machinery of Human Cells

    1 Introduction

    2 Iron Import across the Plasma Membrane

    3 Iron Exporters and their Implications in Human Diseases

    4 Intracellular Iron Transport and Iron Chaperones

    5 Mitochondrial Iron Import and Export

    6 Future Directions

    Chapter Four Structure and Function of Copper Uptake Transporters

    1 Introduction

    2 CTR—A Conserved Family of CTRs

    3 The Structure of Human CTR1

    4 Implications for the Mechanism of Copper Transport

    5 Copper Transport in the Physiological Milieu

    6 Structure–Function Relations in CTR proteins

    Chapter Five Toward a Molecular Understanding of Metal Transport by P1B-Type ATPases

    1 Introduction

    2 Mechanism

    3 Structure

    4 Future Directions and Challenges

    Chapter Six Regulation of Copper Transporters in Human Cells

    1 Copper Auto Regulates its Cytoplasmic Levels by Modulating the Amounts of a High-Affinity Transporter CTR1 at the Plasma Membrane

    2 Regulation of Copper Export via Protein Trafficking and Kinase-Mediated Phosphorylation

    3 Redox Control of Copper Uptake and Efflux from Human Cells

    Chapter Seven Metal Export by CusCFBA, the Periplasmic Cu(I)/Ag(I) Transport System of Escherichia coli

    1 Introduction

    2 Cus System Components

    3 Cus Complex Assembly and Mechanism

    Chapter Eight Molecular Architecture and Function of ZnT Transporters

    1 Introduction

    2 Structure and Transport Mechanism

    3 Expression and Subcellular Localization

    4 Physiological Significance

    5 Conclusion

    Chapter Nine The Cation Selectivity of the ZIP Transporters

    1 Introduction

    2 Mammalian Zinc Transporter Subfamilies

    3 Cation Selectivity of the ZIP Proteins

    4 Future Perspectives

    Chapter Ten Nramp

    1 Introduction

    2 A Family of Membrane Permeases Highly Conserved from Bacteria to Man

    3 The Nramp Family is Distantly Related to the LeuT Superfamily

    4 Structure–Function Relationships Among Slc11 Carriers

    5 Regulation of Bacterial mnth Expression and Virulence

    6 Nramp Role in Eukaryotic Host Defense

    7 Natural Evolution of Nramp in Nutritional Immunity

    8 Pathological Implications of Nramp Function

    9 Conclusions

    Chapter Eleven Genetic and Biochemical Approaches for Studying the Yellow Stripe-Like Transporter Family in Plants

    1 Introduction

    2 Founders of the Family: The YS Transporters

    3 Genetic Studies of YSL Genes

    4 Biochemical Studies of YSL Genes

    5 Conclusions and Future Perspectives

    Chapter Twelve Pathways of Arsenic Uptake and Efflux

    1 Introduction

    2 Uptake Systems for Arsenic

    3 Efflux Systems for Arsenic

    4 The ArsD As(III) Metallochaperone and Its Interaction with the ArsA ATPase

    Chapter Thirteen Extracellular Heme Uptake and the Challenges of Bacterial Cell Membranes

    1 Introduction

    2 Heme Capture and Transport Across the Cell Wall and Membranes

    3 Transmembrane Heme Sensors and ATP-Dependent Efflux Pumps

    4 Heme Uptake and Utilization in Antimicrobial Drug Development

    5 Future Perspectives

    Chapter Fourteen The Mechanisms of Mg2+ and Co2+ Transport by the CorA Family of Divalent Cation Transporters

    1 Overview

    2 Introduction

    3 Properties of Mg2+ and Co2+

    4 The CorA Family of Mg2+/Co2+ Transporters

    5 The Mechanisms of Mg2+ and Co2+ Transport Through CorA

    6 Concluding Remarks


    Color Plates

Product details

  • No. of pages: 456
  • Language: English
  • Copyright: © Academic Press 2012
  • Published: October 5, 2012
  • Imprint: Academic Press
  • eBook ISBN: 9780123946102
  • Hardcover ISBN: 9780123943903

About the Serial Volume Editors

Jose Arguello

Affiliations and Expertise

Worcester Polytechnic Institute

Svetlana Lutsenko

Affiliations and Expertise

Professor of Physiology Johns Hopkins University

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