Metal Oxides for Biomedical and Biosensor Applications

Metal Oxides for Biomedical and Biosensor Applications

1st Edition - December 3, 2021

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  • Editors: Kunal Mondal, Ghenadii Korotcenkov
  • Paperback ISBN: 9780128230336
  • eBook ISBN: 9780128230589

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Description

Metal Oxides for Biomedical and Biosensor Applications gives an in-depth overview of the emerging research in the biomedical and biosensing applications of metal oxides, including optimization of their surface and bulk properties. Sections cover biomedical applications of metal oxides for use in cell cultures, antibacterial and antimicrobial treatments, dental applications, drug delivery, cancer therapy, immunotherapy, photothermal therapy, tissue engineering, and metal oxide-based biosensor development. As advanced and biofunctionalized nano/micro structured metal oxides are finding applications in microfluidics, optical sensors, electrochemical sensors, DNA-based biosensing, imaging, diagnosis and analysis, this book provides a comprehensive update on the topic. Additional sections cover research challenges, technology limitations, and future trends in metal oxides and their composites regarding their usage in biomedical applications.

Key Features

  • Includes an overview of the important applications of metal oxides for biomedical and biosensing technologies
  • Addresses the relationship between material properties, such as structure, morphology, composition and performance
  • Reviews the design and fabrication strategies of metal oxides for use in medical and biosensing applications

Readership

Materials Science and Engineering. Physicists

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • List of contributors
  • Series editor biography
  • Preface to the series
  • Section 1: Biomedical applications of metal oxides
  • 1. Bioactivity, biocompatibility, and toxicity of metal oxides
  • Abstract
  • 1.1 Introduction
  • 1.2 Metals oxides and their biomedical applications
  • 1.3 Bioactivity of metal oxides
  • 1.4 Biocompatibility of metal oxide
  • 1.5 Toxicity of metal oxides
  • 1.6 Summary
  • References
  • Further reading
  • 2. Drug delivery using metal oxide nanoparticles
  • Abstract
  • 2.1 Introduction
  • 2.2 Metal oxide-based nanoparticles for drug delivery and other biomedical applications
  • 2.3 Concluding remarks and perspectives
  • References
  • 3. Cancer therapy, immunotherapy, photothermal therapy
  • Abstract
  • 3.1 Introduction
  • 3.2 Cancer biology and nanoparticles
  • 3.3 Metal oxides for cancer therapy
  • 3.4 Iron oxides for cancer therapy
  • 3.5 Titanium dioxides for cancer therapy
  • 3.6 Zinc oxides for cancer therapy
  • 3.7 Transition metal oxides for cancer therapy
  • 3.8 Metal oxides for immunotherapy
  • 3.9 Nanoparticles elicit immune responses by delivering targeted antigens
  • 3.10 Cobalt oxides as immunotherapeutic agents
  • 3.11 Hydroxides as immunotherapeutic agents
  • 3.12 Iron oxides as immunotherapeutic agents
  • 3.13 Graphene oxides as immunotherapeutic agents
  • 3.14 Metal oxides for photothermal therapy
  • 3.15 Graphene oxides as photothermal agents
  • 3.16 Titanium dioxide as photothermal agents
  • 3.17 Iron oxides as photothermal agents
  • 3.18 Manganese oxides as photothermal agents
  • 3.19 Conclusions
  • References
  • 4. Metal oxides for cosmetics and sunscreens
  • Abstract
  • 4.1 Introduction
  • 4.2 Applications of metal oxides in cosmetics and sunscreens
  • 4.3 Mechanism of dermal absorption and toxicity of metal oxides in human skin
  • 4.4 Discussion and conclusions
  • References
  • 5. Tissue engineering
  • Abstract
  • 5.1 Metal oxides
  • 5.2 Application of nanotechnology in tissue engineering
  • 5.3 Application of metal oxides in tissue engineering
  • References
  • 6. Role of light-active metal oxide-based nanohybrids in biofilm annihilation devices
  • Abstract
  • 6.1 What this chapter seeks to do
  • 6.2 Formation of bonds: molecules
  • 6.3 Bonds to bands: solids
  • 6.4 Nanocrystals: effects of surface and size
  • 6.5 Nanocrystal–molecule interactions—the microscopic picture
  • 6.6 Nanocrystal–molecule interactions—antibacterial action
  • 6.7 Nanocrystal-molecule hybrids against biofilms
  • 6.8 Outlook
  • Acknowledgment
  • References
  • Section 2: Metal oxide-based biosensors
  • 7. Introduction to metal oxide-based biosensing
  • Abstract
  • 7.1 Introduction
  • 7.2 Synthesis strategies of metal oxides for biosensors
  • 7.3 Microsystems biosensing devices
  • 7.4 Conclusions and future visions
  • Acknowledgments
  • References
  • 8. Exploring the potential of metal oxides for biomedical applications
  • Abstract
  • 8.1 Introduction
  • 8.2 Physicochemical properties of metal oxide nanoparticles
  • 8.3 Commonly used metal oxides for biomedical applications
  • 8.4 Conclusion and future perspectives
  • References
  • 9. Surface coating and functionalization of metal and metal oxide nanoparticles for biomedical applications
  • Abstract
  • 9.1 Introduction
  • 9.2 Metal nanoparticles
  • 9.3 Metal oxide nanoparticles
  • 9.4 Metal and metal oxide functionalization
  • 9.5 Metal and metal oxide nanoparticles
  • 9.6 Conclusions
  • Acknowledgments
  • References
  • 10. Metal oxidesbased microfluidic biosensing
  • Abstract
  • 10.1 Introduction
  • 10.2 Basics of microfluidics
  • 10.3 Microfluidic metal oxide biosensors
  • 10.4 Conclusion
  • References
  • 11. Metal/metal oxides for electrochemical DNA biosensing
  • Abstract
  • 11.1 Introduction in DNA biosensing
  • 11.2 Fundamental properties of nanostructured metal oxides used for DNA biosensing
  • 11.3 Size and surface particularities
  • 11.4 Surface energy and electrical properties
  • 11.5 Stability and reactivity
  • 11.6 Biosensors based on DNA-functionalized nanostructured metal oxides
  • 11.7 Metallic and semiconducting oxides used in DNA biosensing
  • 11.8 DNA biosensors applications
  • 11.9 Eukaryotic cells and microorganisms
  • 11.10 DNA-based metal sensing
  • 11.11 Conclusions and future perspectives
  • References
  • 12. Metal oxides and their composites as flow-through biosensors for biomonitoring
  • Abstract
  • 12.1 Introduction
  • 12.2 Microfluidic devices
  • 12.3 Methods for fabrication of microfluidic channels
  • 12.4 Microfluidic and nanofluidic biosensor platforms
  • 12.5 Biosensors: how they work? What are the benefits of biosensors in modern life?
  • 12.6 Metal oxides and their composites in microfluidic biosensing
  • 12.7 New advancement in microfluidic biosensors
  • 12.8 Future perspective
  • References
  • 13. Nanomaterials of metal and metal oxides for optical biosensing application
  • Abstract
  • 13.1 Introduction
  • 13.2 Optical biosensing strategies
  • 13.3 Conclusion
  • Acknowledgment
  • References
  • 14. Metal oxides for detection of cardiac biomarkers
  • Abstract
  • 14.1 Introduction
  • 14.2 Biomarkers for diagnosis
  • 14.3 Future prospects and conclusion
  • References
  • Section 3: Specific metal oxides and their biomedical applications
  • 15. Regulating cell function through micro- and nanostructured transition metal oxides
  • Abstract
  • 15.1 Introduction
  • 15.2 Cellular response to transition metal oxide micro- and nanostructures
  • References
  • 16. Biomedical application of ZnO nanoscale materials
  • Abstract
  • 16.1 Introduction
  • 16.2 ZnO metal oxide
  • 16.3 Nanostructures and the growth processes
  • 16.4 Synthesis techniques for ZnO nanomaterials
  • 16.5 Biomedical applications
  • 16.6 Mechanism
  • 16.7 Conclusion
  • References
  • 17. Recent progress on titanium oxide nanostructures for biosensing applications
  • Abstract
  • 17.1 Introduction
  • 17.2 Properties of TiO2
  • 17.3 Synthesis of TiO2 nanostructures for biosensors
  • 17.4 Working principle of TiO2 biosensors
  • 17.5 TiO2 biosensors
  • 17.6 Conclusion
  • References
  • 18. ZrO2 in biomedical applications
  • Abstract
  • 18.1 Introduction
  • 18.2 Applications of zirconia
  • References
  • 19. Iron oxides and their prospects for biomedical applications
  • Abstract
  • 19.1 Introduction: iron oxide in biomedical applications
  • 19.2 Synthesis of iron oxide nanoparticles with respect to biomedical applications
  • 19.3 Methods of physicochemical characterization
  • 19.4 Methods for functionalization of metal nanoparticles for biomedical applications
  • 19.5 Biomedical applications
  • 19.6 Conclusion
  • Acknowledgments
  • References
  • 20. Flexible and stretchable indium-fallium-zinc oxide-based electronic devices for sweat pH sensor application
  • Abstract
  • 20.1 Overview of oxides-based electronic devices
  • 20.2 Flexible and stretchable IGZO-based field effect transistors
  • 20.3 Sweat pH sensor using flexible IGZO field effect transistors
  • 20.4 Conclusion
  • References
  • 21. Layered metal oxides for biomedical applications
  • Abstract
  • 21.1 Introduction
  • 21.2 Structures and polymorphs of layered metal oxides
  • 21.3 Synthesis
  • 21.4 Functionalization of layered metal oxides
  • 21.5 Toxicity
  • 21.6 Applications
  • 21.7 Conclusion and outlook
  • References
  • 22. Metal oxide/graphene nanocomposites and their biomedical applications
  • Abstract
  • 22.1 Introduction
  • 22.2 Synthesis of graphene and its derivatives
  • 22.3 Graphene-based biosensors
  • 22.4 Graphene-based nanocomposites for gene and drug delivery
  • 22.5 Metal oxide-modified graphene nanostructures for antibacterial applications
  • 22.6 Graphene-based wearable devices for biomedical applications
  • References
  • 23. Liquid metal-based soft actuators and sensors for biomedical applications
  • Abstract
  • 23.1 Introduction
  • 23.2 Soft actuators
  • 23.3 Soft sensors
  • 23.4 Summary
  • References
  • Index

Product details

  • No. of pages: 580
  • Language: English
  • Copyright: © Elsevier 2021
  • Published: December 3, 2021
  • Imprint: Elsevier
  • Paperback ISBN: 9780128230336
  • eBook ISBN: 9780128230589

About the Editors

Kunal Mondal

Dr. Kunal Mondal is a Staff Scientist at the Idaho National Laboratory in the Materials Science and Engineering Department. His research interests include the micro/nano fabrication of functional materials, materials for extreme environments, soft and stretchable electronics, microfluidics, carbon MEMS/NEMS for soft electronic skin and flexible transistors.

Affiliations and Expertise

Materials Science and Engineering Department, Idaho National Laboratory, USA

Ghenadii Korotcenkov

Ghenadii Korotcenkov received his Ph.D. in Physics and Technology of Semiconductor Materials and Devices in 1976, and his Doctor Habilitate Degree in Physics and Mathematics of Semiconductors and Dielectrics in 1990. Long time he was a leader of scientific Gas Sensor Group and manager of various national and international scientific and engineering projects carried out in Laboratory of Micro- and Optoelectronics, Technical University of Moldova, supported from International Foundations and Programs such as CRDF, MRDA, IREX, ICTP, INTAS, INCO-COPERNICUS, COST, NATO. From 2007 to 2008, he was an invited scientist in Korean Institute of Energy Research, Daejeon, South Korea. Then, until the end of 2017 Dr. G. Korotcenkov was a research professor at the School of Materials Science and Engineering at Gwangju Institute of Science and Technology, Gwangju, South Korea. Currently Dr. G. Korotcenkov is the research professor at the Department of Physics and Engineering at the Moldova State University, Chisinau, the Rep. of Moldova. Specialists from Former Soviet Union know G. Korotcenkov’s research results in the field of study of Schottky barriers, MOS structures, native oxides, and photoreceivers on the base of III-Vs compounds very well. His current research interests include material sciences focused on metal oxides, surface science, and the design of thin film gas sensors and thermoelectric convertors. Dr. G. Korotcenkov is either the author or editor of 39 books, published by Momentum Press, CRC Press, Springer (USA) and Harbin Institute of Technology Press (China). He is the author and coauthor of more than 600 scientific publications, including 30 review papers, 38 book chapters, and more than 200 articles published in peer-reviewed scientific journals (h-factor = 42 [Scopus] and h-factor = 51 [Google Scholar citation]). Besides, Dr. G. Korotcenkov is a holder of 17 patents. He has presented more than 250 reports at national and international conferences, including 17 invited talks. Dr. G. Korotcenkov was co-organizer of more than 10 international scientific conferences. Research activities of Dr. G. Korotcenkov are honored by the Prize of the Academy of Sciences of Moldova (2019), an Award of the Supreme Council of Science and Advanced Technology of the Republic of Moldova (2004); Prize of the Presidents of the Ukrainian, Belarus, and Moldovan Academies of Sciences (2003); and National Youth Prize of the Republic of Moldova in the field of science and technology (1980), among others.

Affiliations and Expertise

Research Professor, Department of Physics and Engineering, Moldova State University, Chisinau, Republic of Moldova

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