Metal Nanoparticles for Drug Delivery and Diagnostic Applications - 1st Edition - ISBN: 9780128169605, 9780128169612

Metal Nanoparticles for Drug Delivery and Diagnostic Applications

1st Edition

Editors: Muhammad Raza Shah Muhammad Imran Shafi Ullah
Paperback ISBN: 9780128169605
eBook ISBN: 9780128169612
Imprint: Elsevier
Published Date: 22nd October 2019
Page Count: 356
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Table of Contents

1. Metal nanoparticles toxicity: role of physicochemical aspects 1

1.1 Introduction 1

1.2 Mechanisms of metallic nanoparticles toxicity 2

1.3 Effect of physicochemical properties on toxicity of metallic nanoparticles 3

1.4 Conclusion 9

References 9

2. Erythrocytes modified (coated) gold nanoparticles for effective drug delivery 13

2.1 Introduction 13

2.2 Nanotechnology and their advancement 14

2.3 Nanosize passage from micro to nanoparticles 15

2.4 Why modern therapeutics diverging to nanoscales? 17

2.5 Nanomaterials and their exploded applications 17

2.6 Metallic nanoparticles 18

2.7 Cells based drug delivery system 18

2.8 Blood cells based derived drug delivery system 20

2.9 Gold nanoparticles 21

2.10 Erythrocytes modified (coated) gold nanoparticles cargo 23

2.11 Application of erythrocytes coated gold nanoparticles 26

2.12 Conclusion 26

References 27

3. Biosynthesized metal nanoparticles as potential Alzheimer’s disease therapeutics 31

3.1 Introduction 31

3.2 Mechanisms and popular hypothesis of Alzheimer’s disease 32

3.3 Neurodegenerative disorders and status of Alzheimer’s disease 33

3.4 Epidemiology/prevalence, continent-based statistics of Alzheimer’s disease 33

3.5 Present therapeutic issues, concerns, disadvantages of Alzheimer’s disease therapies 34

3.6 Nanomedicines for Alzheimer’s disease with specific reference to the metal nanoparticles 36

3.7 Biogenic nanoparticles as promising Alzheimer’s disease theranostic agents 37

3.8 Conclusion and future prospects 39

References 39

4. Gold nanoparticles in cancer diagnosis and therapy 43

4.1 Introduction 43

4.2 Gold nanoparticles 45

4.3 Gold nanoparticles in cancer therapy and diagnosis 46

4.4 Gold nanoparticles in clinical trials 52

4.5 Safety concerns of gold nanoparticles 52

4.6 Conclusion 53

References 53

5. Gold nanorods: new generation drug delivery platform 59

5.1 Introduction 59

5.2 Optical properties 61

5.3 Synthesis 62

5.4 Catalytic method 69

5.5 Self-assembly of gold nanorods 69

5.6 Gold nanorods applications in diagnostics 71

5.7 Gold nanorod applications in drug delivery 75

5.8 Conclusion 79

References 80

6. Surface engineered gold nanorods: intelligent delivery system for cancer therapy 85

6.1 Introduction 85

6.2 Nanotechnology 87

6.3 Conclusion 94

References 95

7. Role of gold- and silver-based nanoparticles in stem cells differentiation 99

7.1 Introduction 99

7.2 Effect on osteogenic differentiation 100

7.3 Effect on chondrogenic differentiation 103

7.4 Effect on adipogenic differentiation 104

7.5 Role of nanoparticles in neuronal differentiation 105

7.6 Role of nanoparticles in cardiac differentiation 105

7.7 Effect on stem cells growth and proliferation 106

7.8 Effect on reactive oxygen species 107

7.9 Nanoparticles in wound healing 108

7.10 Nanoparticles in cancer stem cells 109

7.11 Cytotoxicity of nanoparticles on stem cells 111

7.12 Conclusion 112

References 112

8. Nanosilver at the interface of biomedical applications, toxicology, and synthetic strategies 119

8.1 Ag nanomaterials 120

8.2 Synthetic strategies of silver nanomaterials 123

8.3 Characterization 125

8.4 Biomedical applications of silver nanomaterials 127

8.5 Toxicology of silver nanomaterials 129

8.6 Summary and future perspectives 134

References 134

9. Silver nanoparticles: a promising nanoplatform for targeted delivery of therapeutics and optimized therapeutic efficacy 141

9.1 Introduction 141

9.2 Biomedical applications of silver nanoparticles 143

9.3 Summary and future prospects 163

Acknowledgment 165

References 165

Further reading 173

10. Bactericidal potentials of silver nanoparticles: novel aspects against multidrug resistance bacteria 175

10.1 Introduction 175

10.2 Mechanisms for bacterial antibiotic resistance 176

10.3 Silver nanoparticles 177

10.4 Antibacterial spectrum of silver nanoparticles 178

10.5 Antibacterial spectrum of silver nanoparticles against multidrug resistance bacteria 179

10.6 Mechanisms of silver nanoparticles bactericidal activity 180

10.7 Conclusion 184

References 184

11. Magnetic nanoparticles: drug delivery and bioimaging applications 189

11.1 Introduction 189

11.2 Synthesis of magnetic nanoparticles 193

11.3 Drug delivery and bioimaging applications 197

11.4 Conclusion 207

References 208

12. Surface functionalized magnetic nanoparticles for targeted cancer therapy and diagnosis 215

12.1 Introduction 216

12.2 Considerations for magnetic nanoparticles design 217

12.3 Functionalization of target specific magnetic nanoparticles 220

12.4 Surface functionalization chemistry 225

12.5 Magnetic nanoparticles targeting strategies and diagnosis 228

12.6 Conclusion 231

References 232

Further reading 236

13. Clinical implications of metals-based drug-delivery systems 237

13.1 Nanotechnology: an introduction 237

13.2 Types of nanoparticles 238

13.3 Biomedical applications of metal nanoparticles 243

13.4 Drawbacks of nanoparticles in drug-delivery system 251

13.5 Conclusion 252

References 253

14. pH-sensitive drug delivery systems 259

14.1 Introduction 259

14.2 Classification of pH-sensitive drug delivery systems 261

14.3 Synthesis of pH-sensitive drug delivery systems 268

14.4 Structure and architecture of pH-sensitive drug delivery systems 269

14.5 Applications of pH-sensitive drug delivery systems at different levels 271

14.6 Conclusion 275

References 276

15. Ionic liquid

15.1 Introduction 280

15.2 Classes of ionic liquids 282

15.3 Nanoparticles 286

15.4 Classification of nanoparticles 286

15.5 Synthesis of nanoparticles 289

15.6 Conclusion 295

References 296

16. Biomedical applications of magnetic nanoparticles 301

16.1 Introduction 302

16.2 Synthesis of magnetic nanoparticles 303

16.3 Surface modification of magnetic nanoparticles 309

16.4 Biomedical applications of magnetic nanoparticles 316

16.5 Conclusion 322

References 323

Index 329


Description

Metal Nanoparticles for Drug Delivery and Diagnostic Applications addresses the lifecycle of metal nanoparticles, from synthesis and characterization, to applications in drug delivery and targeting. It is an important resource for those in biomaterials, nanomedicine and pharmaceutical sciences, exploring gold, silver and iron-based drug delivery systems for controlled and targeted delivery of potential drugs and genes for enhanced clinical efficacy. Nanotechnology is widely used in drug delivery due to its ability to reduce plasma fluctuation of drugs, high solubility, and efficiency, the relatively low cost of nanoscale products, and enhancement of patient comfort, hence this resource is a welcome edition to the science.

Key Features

  • Illustrates the progression of nanoparticle therapeutics from basic research to applications
  • Explores new opportunities and ideas for developing and improving technologies in nanomedicine and nanobiology
  • Discusses the toxicity of different types of metal nanoparticles and how to ensure their safe use

Readership

Materials scientists, biomedical scientists, pharmaceutical scientists


Details

No. of pages:
356
Language:
English
Copyright:
© Elsevier 2020
Published:
22nd October 2019
Imprint:
Elsevier
Paperback ISBN:
9780128169605
eBook ISBN:
9780128169612

Ratings and Reviews


About the Editors

Muhammad Raza Shah Editor

Muhammad Raza Shah is a Full Professor at the International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University of Karachi, Pakistan. He is also the Head of the Center for Bioequivalence Studies and Clinical Research (CBSCR) and the recipient of numerous awards, including the civil award Tamgha-i-Imtiaz from President of Pakistan, and the Dr. M. Raziuddin Siddiqi Prize (2015) for Scientists under 40 in the Field of Chemistry by Pakistan Academy of Sciences. He has written over 200 peer-reviewed journal papers.

Affiliations and Expertise

Full Professor, International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University, Karachi, Pakistan

Muhammad Imran Editor

Muhammad Imran is a graduate student and based at the International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University of Karachi, Pakistan.

Affiliations and Expertise

International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Pakistan

Shafi Ullah Editor

Shafi Ullah is a graduate student and based at the International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University of Karachi, Pakistan.

Affiliations and Expertise

International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Pakistan