Metabolic Transport

Metabolic Transport

1st Edition - January 1, 1972

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  • Editor: Lowell Hokin
  • eBook ISBN: 9780323142977

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Metabolic Pathways, Third Edition: Metabolic Transport, Volume VI investigates membrane transport and its role in cell physiology. The book describes the transport of solutes across membranes and of carbohydrates in bacterial cells, as well as other processes such as cellular transport of water, amino acid transport in microorganisms, proton transport, and calcium transport by the sarcoplasmic reticulum. Organized into 16 chapters, this volume begins with an overview of the kinetics of transport, emphasizing the monovalent carrier mechanism of facilitated diffusion and active transport involving monovalent carriers. The book then introduces the reader to the transport of various ligands by animal cells or microorganisms; transport by intracellular organelles; and the role of sodium pump in animal tissues in the regulation of cellular metabolism and function. The book also examines the transport of biogenic amines and some mechanisms involved in the control of transport. A few examples of the role of transport in subserving other cellular processes are presented. This book is a valuable source of information for workers in the transport field, along with biologists whose research interests overlap with the transport field.

Table of Contents

  • List of Contributors


    Contents of Other Volumes

    Volumes in Series

    Errata for Volume III

    Chapter 1 The Use of the Steady-State Assumption to Derive Kinetic Formulations for the Transport of a Solute across a Membrane

    Glossary 1

    I. Introduction

    II. Rate Equations for the Monovalent Carrier Mechanism of Facilitated Diffusion

    III. Active Transport Involving Monovalent Carrier

    IV. Two Substrates Competing for the Same Site on a Monovalent Carrier


    Chapter 2 Ion Transport in Microorganisms

    I. Introduction

    II. Monovalent Cation Transport

    III. Anion Transport

    IV. Bivalent Cations

    V. Cation Binding by the Cell Surface

    VI. Control of Transport

    VII. Functions of Transport Systems

    VIII. Discussion


    Chapter 3 Carbohydrate Transport in Bacterial Cells

    I. Introduction

    II. Modes of Transport

    III. The Phosphotransferase System

    IV. Transport Studies with Membrane Vesicles

    V. Concluding Remarks


    Chapter 4 Cellular Transport of Water

    I. Water Transport—Basic Concepts

    II. Net Water Fluxes across the Cell Membrane

    III. Inadequate Aspects of the Leak-and-Pump Hypothesis

    IV. Concluding Remarks


    Chapter 5 Amino Acid Transport in Microorganisms

    I. Introduction

    II. General Considerations

    III. Transport Systems

    IV. Alkali Metal and Ammonium Ion Effects

    V. Isolation of Transport Systems


    Chapter 6 Proton Transport

    I. Introduction

    II. Passive Proton Transport

    III. Active Proton Transport


    Chapter 7 The Sodium Pump in Animal Tissues and Its Role in the Control of Cellular Metabolism and Function

    I. Introduction

    II. Properties of the Na Pump in Animal Cells

    III. Interactions between the Na Pump and Cellular Metabolism and Function

    IV. Control of Pumping Capacity


    Chapter 8 The Sodium-Potassium Adenosinetriphosphatase

    I. Introduction

    II. Properties of the Enzyme

    III. Lipid Requirement

    IV. Reaction Mechanism

    V. Cardiac Glycosides

    VI. Purification

    VII. Phosphorylated Subunit

    VIII. Conformational Changes

    IX. Models for Na and Κ Transport


    Chapter 9 Transport of Calcium by the Sarcoplasmic Reticulum

    I. Introduction

    II. Regulation of the Contraction-Relaxation Cycle by Sarcoplasmic Reticulum. A Historic Outline

    III. Transport of Ca2+ by Fragmented Sarcoplasmic Reticulum


    Note Added in Proof

    Chapter 10 Calcium Transport by Selected Animal Cells and Tissues

    I. Introduction

    II. Isolated Kidney and HeLa Cells

    III. Calcium Transport by the Erythrocyte

    IV. Calcium Transport in Bone Cells

    V. Chorioallantoic Membrane of the Avian Egg

    VI. The Avian Shell Gland

    VII. Intestinal Calcium Transport

    VIII. Summation


    Chapter 11 Transport of Carbohydrates by Animal Cells

    I. Introduction

    II. The Facilitated Diffusion Systems

    III. The Active Transport Systems

    IV. Attempts at Carrier Extraction or Site Identification


    Chapter 12 Transport of Amino Acids by Animal Cells


    I. General

    II. Special Systems of Amino Acid Transport


    Note Added in Proof

    Chapter 13 The Transport of Biogenic Amines

    I. Introduction

    II. Biogenic Amine Transport in the Peripheral Adrenergic Neuron

    III. Transport of Biogenic Amines in the Central Nervous System

    IV. Biogenic Amine Transport in Blood Platelets

    V. Biogenic Amine Transport in Mast Cells

    VI. Biogenic Amine Transport in the Adrenal Medullary Vesicle

    VII. Biogenic Amine Transport in Tissues Not Containing Amine Storage Vesicles

    VIII. Summary


    Chapter 14 Transport of Drugs

    I. Introduction

    II. Distinction between Active Transport and Passive Transfer

    III. Small Intestine

    IV. Central Nervous System

    V. Eye

    VI. Liver

    VII. Kidney


    Chapter 15 Mechanisms of Mitochondrial Ion Transport

    I. Introduction

    II. Monovalent Cation Transport

    III. Divalent Cation Transport

    IV. Anion Transport

    V. Nucleotide Transport

    VI. Nonelectrolytes

    VII. Energetics of Ion Transport

    VIII. The Mechanisms of Ion Transport


    Chapter 16 Some Mechanisms for Hormonal Effects on Substrate Transport

    I. Introduction

    II. Effects on Sugar Transport

    III. Amino Acids

    IV. Cations

    V. Concerning Mechanisms

    VI. Water, Sodium and ADH

    VII. Mineralocorticoids

    VIII. Effects of Growth Hormone


    Author Index

    Subject Index

Product details

  • No. of pages: 726
  • Language: English
  • Copyright: © Academic Press 1972
  • Published: January 1, 1972
  • Imprint: Academic Press
  • eBook ISBN: 9780323142977

About the Editor

Lowell Hokin

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