Metabolic Inhibitors V4

Metabolic Inhibitors V4

A Comprehensive Treatise

1st Edition - January 1, 1973

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  • Editor: R Hochster
  • eBook ISBN: 9780323147071

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Metabolic Inhibitors: A Comprehensive Treatise, Volume IV reviews developments in studies of inhibition of metabolic and enzymic processes ranging from photosynthesis and blood clotting to protein synthesis, fatty acid metabolism, and phospholipid metabolism. The book also explores the inhibition of specific enzyme reactions, such as amino acid activation, amino acid hydroxylation, and cyclic AMP formation. Organized into nine chapters, this volume begins with an overview of allosteric inhibition and inhibitors, and then discusses amino acid hydroxylase inhibitors. The reader is also introduced to inhibitors and activators of enzymes that regulate the cellular concentration of cyclic AMP. In particular, the book describes the role of lipids in the activation of adenyl cyclase by hormones; modification of adenyl cyclase in various physiological and pathological conditions; and synthesis of glycerophosphatides as well as phospho- and glycosphingolipids. This book is a valuable source of information for biochemists and medical research workers as well as virologists, microbiologists, plant physiologists, and agronomists.

Table of Contents

  • List of Contributors


    Contents of Other Volumes

    Chapter 1 Allosteric Inhibitors

    I. Introduction

    II. Limiting Models for Allosteric Inhibition

    III. Methods That Probe Mechanisms of Allosteric Inhibition

    IV. Variation of Allosteric Properties among Source Organisms

    V. Classes of Allosteric Inhibitors

    VI. Allosteric Inhibition of Specific Enzymes

    VII. Allosteric Inhibition in Enzyme Complexes and Membrane Systems


    Chapter 2 Amino Acid Hydroxylase Inhibitors

    I. Introduction

    II. Properties of the Enzymes

    III. In Vitro Inhibitors of the Hydroxylases

    IV. In Vivo Inhibitors of the Hydroxylases

    V. Indirect Mechanisms of Inhibition

    VI. Conclusion


    Chapter 3 Inhibitors of Amino Acid Activation

    I. Introduction

    II. Noncompetitive Inhibitors

    III. Competitive Inhibitors

    IV. Conclusion


    Chapter 4 Inhibitors of Protein Synthesis

    I. Introduction

    II. Protein Biosynthesis

    III. Inhibitors of Peptide Chain Initiation

    IV. Inhibitors of Peptide Chain Elongation

    V. Inhibitors of Peptide Chain Termination

    VI. Premature Peptide Chain Termination

    VII. Other Inhibitors

    VIII. Summary


    Chapter 5 Inhibition of Photosynthesis

    I. Introduction

    II. The Overall Mechanism of Photosynthesis

    III. Light-Dependent Reactions of Chloroplast Lamellae

    IV. Partial Reactions of Photosynthesis in Isolated Chloroplast Lamellae

    V. Inhibitions of Electron Transport and Phosphorylation in Chloroplast Lamellae

    VI. Inhibition of the Fixation and Reduction of Carbon Dioxide

    VII. Photorespiration and the Inhibition of Photosynthesis by Oxygen

    VIII. Indirect Inhibitions and the Physiological Control of Photosynthesis

    IX. Conclusion


    Chapter 6 Inhibitors of Blood-Clotting Mechanisms

    I. Introduction

    II. Inhibitors of Enzyme Action

    III. Inhibitors of Coagulant Protein Biosynthesis

    IV. Hereditary Inhibitors

    V. Acquired Circulating Anticoagulants

    VI. Fibrinogen Degradation Products

    VII. Inhibitors of Lipids and Lipoproteins

    VIII. Inhibitors of Intravascular Coagulation and Thrombosis

    IX. The Role of Heparin in Blood Coagulation

    X. Concluding Remarks


    Chapter 7 Inhibitors of Fatty Acid Oxidation and the Pathway of Fatty Acid Biosynthesis from Glucose

    I. Fatty Acid Oxidation

    II. Inhibition of Pathways of Fatty Acid Synthesis

    III. Concluding Comments


    Chapter 8 Inhibitors of Enzymes of Phospholipid and Sphingolipid Metabolism

    I. Introduction

    II. Phospholipid Hydrolases

    III. Glycosphingolipid Hydrolases

    IV. Synthesis of the Glycerophosphatides

    V. Synthesis of Phospho- and Glycosphingolipids

    VI. Metabolism of the Sphingosine Bases

    VII. Summary and Conclusions


    Chapter 9 Inhibitors and Activators of Enzymes Regulating the Cellular Concentration of Cyclic AMP

    I. Introduction

    II. Distribution, Subcellular Location, Purification, and Properties of Adenyl Cyclase and Cyclic AMP Phosphodiesterase

    III. Regulation of Intracellular Levels of Cyclic AMP

    IV. Regulation of Cyclic AMP Formation in Cells in Culture

    V. Adenyl Cyclase and Phosphodiesterase in Relation to Age

    VI. Role of Lipids in the Activation of Adenyl Cyclase by Hormones

    VII. Modification of Adenyl Cyclase in Various Physiological and Pathological Conditions

    VIII. Concluding Remarks


    Author Index

    Subject Index

Product details

  • No. of pages: 528
  • Language: English
  • Copyright: © Academic Press 1973
  • Published: January 1, 1973
  • Imprint: Academic Press
  • eBook ISBN: 9780323147071

About the Editor

R Hochster

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