Metabolic Inhibitors V1

A Comprehensive Treatise

1st Edition - January 1, 1963
Editor: R Hochster
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 4 3 3 8 - 7

Metabolic Inhibitors: A Comprehensive Treatise, Volume I focuses on the properties of inhibitors of metabolic processes or enzyme systems. The book explores a wide range of… Read more

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Metabolic Inhibitors: A Comprehensive Treatise, Volume I focuses on the properties of inhibitors of metabolic processes or enzyme systems. The book explores a wide range of substances that interfere with (and usually retard) metabolic and enzymic processes, emphasizing the inhibitor rather than the metabolic or enzymic system that is affected. Organized into 15 chapters, this volume begins with a historical overview of research on the mode of action of biological inhibitors, touching on the principle of competitive inhibition by structural analogues. The book then turns to the concept of a competitive enzymic relationship by growth inhibitory analogues and their corresponding amino acids; the metabolic inhibitory effects of polypeptides and proteins; and the use of pentoses as analogues in carbohydrate metabolism. The reader is also introduced to the metabolic inhibitory effects of fatty acids; the intermediary metabolism of phospholipids; and the inhibition of purine and pyrimidine analogues. The remaining chapters discuss the role of nucleic acids and nucleoproteins in the regulation of cellular metabolism and the inhibition of amino acid decarboxylases, cholesterol, and steroid biosynthesis. This book will be of value to biochemists, advanced students, medical research workers, and research workers in the various fields of biological chemistry, as well as those working in the microbiological, botanical, and other agricultural fields.

List of Contributors

Preface and Introduction

Contents of Volume II

Chapter 1 Amino Acid Analogues

I. Introduction

II. Amino Acid Antagonists

III. Antagonisms among Amino Acids Essential for Protein Synthesis

IV. Biological Studies Involving Amino Acid Inhibitors

References

Chapter 2 Polypeptides and Proteins as Inhibitors

I. Introduction

II. Polypeptide Antibiotics

III. Natural Protein and Polypeptide Inhibitors

IV. Synthetic Poly-α-Amino Acids

V. Analogues of the Polypeptide and Protein Hormones

VI. Modified Enzymes as Inhibitors

VII. Miscellaneous Di-and Tripeptide Inhibitors

VIII. Concluding Remarks

References

Chapter 3 Hexose and Pentose Analogues

I. Introduction

II. Hexoses

III. Pentoses

IV. Conclusions

References

Chapter 4 Fatty Acids and Their Analogues

I. Metabolic Inhibitory Effects of Normal Fatty Acids

II. Metabolic Inhibitory Effects of Acyl Coenzyme a Derivatives

III. Fatty Acid Analogues

References

Chapter 5 Phospholipids

I. Phospholipid Catabolism

II. Phospholipid Synthesis

III. Ion Transport and Phospholipid Metabolism

IV. Alternative Pathway for Lecithin Synthesis; Transmethylation Involving Glycerophosphatides

V. Conclusions

References

Chapter 6 Purine Analogues

I. Introduction

II. Cellular Multiplication

III. Effects in the Whole Organism

IV. Effects on Function

V. Biochemical Effects

VI. Conclusion

References

Chapter 7 Pyrimidine Analogues

I. Introduction

II. Biosynthesis and Metabolic Functions of Pyrimidine Nucleotides

III. Pyrimidine Analogues

IV. Other Inhibitors of Pyrimidine Nucleotide Biosynthesis

References

Chapter 8 Nucleic Acids and Nucleoproteins

I. Introduction

II. The Nucleic Acids: Their Role in the Control of Cellular Metabolism

III. Virus Infection

References

Chapter 9 Inhibition of Amino Acid Decarboxylases

I. Introduction

II. Pyridoxal Kinase

III. Apoenzyme-Coenzyme Dissociation

IV. Transport, Uptake, Binding, Release

V. Inanition

VI. Tissue Damage, Growth, Neoplasms, Organectomy

VII. Apoenzyme Synthesis

VIII. Inhibition by Apoenzyme Antibody

IX. Metals, Chelators, and Metal Complexers

X. Cyanide

XI. Pyridoxal-5-Phosphate (Codecarboxylase), Vitamin B6, B6-Deficiency, B6-Antagonists

XII. Activators, Stabilizers, and Cofactors Other Than B6-P04

XIII. Carbonyl Reagents and Inhibitors Acting on Coenzyme Other Than Cyanide, Substrate Analogues, and Pyridoxine Antagonists

XIV. Hormones

XV. Miscellaneous

XVI. Substrate Analogues

References

Chapter 10 Inhibitors, Antagonists, and Inactivators in the Etiology of Diabetes Mellitus in Man

I. Introduction

II. Insulinogenesis

III. Release of Insulin

IV. Impairment of Insulinogenesis

V. Impairment of Insulin Release

VI. Impairment in Transport of Insulin

VII. Inhibitors of Insulin

VIII. Impairment of Insulin Receptor Sites

IX. Antagonists of Action of Insulin

X. Excretion of Insulin

XI. Degradation of Insulin

XII. Inhibitors of Insulin Degradation

XIII. Summary

References

Chapter 11 Antagonists and Inhibitors of the Fat-soluble Vitamins

I. Vitamin A

II. Vitamin D

III. Vitamin Ε

IV. Vitamin Κ

References

Chapter 12 Antimetabolites of the Water-soluble Vitamins

I. General Principles of Antimetabolite Action

II. Antimetabolites of Water-soluble Vitamins

References

Chapter 13 Sulfonamides and Folic Acid Antagonists

I. Introduction

II. Sulfonamides

III. Folic Acid in Enzymic Reactions

IV. Folic Acid Antagonists

References

Chapter 14 Thyroxine Analogues

I. Introduction

II. Techniques of Evaluating Thyroxine Inhibitors

III. Early Studies of Compounds Related to Diiodotyrosine

IV. Ethers of Diiodotyrosine and Related Compounds

V. Derivatives of Diiodohydroxybenzoic Acid

VI. Iodinated Phenoxyacetic Acids

VII. Partially Iodinated Thyronines and Related Compounds

VIII. General Survey of Inhibitory Structures

References

Chapter 15 Inhibitors of Steroid Actions and Cholesterol and Steroid Biosynthesis

I. Introduction

II. Inhibition of Estrogenic Activity

III. Inhibition of Androgenic Activity

IV. Inhibition of Corticoid Activity

V. Inhibition of Steroid Biosynthesis

VI. Inhibition of Cholesterol Biosynthesis ·

References

Author Index

Subject Index