Metabolic Inhibitors V1

Metabolic Inhibitors V1

A Comprehensive Treatise

1st Edition - January 1, 1963

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  • Editor: R Hochster
  • eBook ISBN: 9780323143387

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Metabolic Inhibitors: A Comprehensive Treatise, Volume I focuses on the properties of inhibitors of metabolic processes or enzyme systems. The book explores a wide range of substances that interfere with (and usually retard) metabolic and enzymic processes, emphasizing the inhibitor rather than the metabolic or enzymic system that is affected. Organized into 15 chapters, this volume begins with a historical overview of research on the mode of action of biological inhibitors, touching on the principle of competitive inhibition by structural analogues. The book then turns to the concept of a competitive enzymic relationship by growth inhibitory analogues and their corresponding amino acids; the metabolic inhibitory effects of polypeptides and proteins; and the use of pentoses as analogues in carbohydrate metabolism. The reader is also introduced to the metabolic inhibitory effects of fatty acids; the intermediary metabolism of phospholipids; and the inhibition of purine and pyrimidine analogues. The remaining chapters discuss the role of nucleic acids and nucleoproteins in the regulation of cellular metabolism and the inhibition of amino acid decarboxylases, cholesterol, and steroid biosynthesis. This book will be of value to biochemists, advanced students, medical research workers, and research workers in the various fields of biological chemistry, as well as those working in the microbiological, botanical, and other agricultural fields.

Table of Contents

  • List of Contributors

    Preface and Introduction

    Contents of Volume II

    Chapter 1 Amino Acid Analogues

    I. Introduction

    II. Amino Acid Antagonists

    III. Antagonisms among Amino Acids Essential for Protein Synthesis

    IV. Biological Studies Involving Amino Acid Inhibitors


    Chapter 2 Polypeptides and Proteins as Inhibitors

    I. Introduction

    II. Polypeptide Antibiotics

    III. Natural Protein and Polypeptide Inhibitors

    IV. Synthetic Poly-α-Amino Acids

    V. Analogues of the Polypeptide and Protein Hormones

    VI. Modified Enzymes as Inhibitors

    VII. Miscellaneous Di-and Tripeptide Inhibitors

    VIII. Concluding Remarks


    Chapter 3 Hexose and Pentose Analogues

    I. Introduction

    II. Hexoses

    III. Pentoses

    IV. Conclusions


    Chapter 4 Fatty Acids and Their Analogues

    I. Metabolic Inhibitory Effects of Normal Fatty Acids

    II. Metabolic Inhibitory Effects of Acyl Coenzyme a Derivatives

    III. Fatty Acid Analogues


    Chapter 5 Phospholipids

    I. Phospholipid Catabolism

    II. Phospholipid Synthesis

    III. Ion Transport and Phospholipid Metabolism

    IV. Alternative Pathway for Lecithin Synthesis; Transmethylation Involving Glycerophosphatides

    V. Conclusions


    Chapter 6 Purine Analogues

    I. Introduction

    II. Cellular Multiplication

    III. Effects in the Whole Organism

    IV. Effects on Function

    V. Biochemical Effects

    VI. Conclusion


    Chapter 7 Pyrimidine Analogues

    I. Introduction

    II. Biosynthesis and Metabolic Functions of Pyrimidine Nucleotides

    III. Pyrimidine Analogues

    IV. Other Inhibitors of Pyrimidine Nucleotide Biosynthesis


    Chapter 8 Nucleic Acids and Nucleoproteins

    I. Introduction

    II. The Nucleic Acids: Their Role in the Control of Cellular Metabolism

    III. Virus Infection


    Chapter 9 Inhibition of Amino Acid Decarboxylases

    I. Introduction

    II. Pyridoxal Kinase

    III. Apoenzyme-Coenzyme Dissociation

    IV. Transport, Uptake, Binding, Release

    V. Inanition

    VI. Tissue Damage, Growth, Neoplasms, Organectomy

    VII. Apoenzyme Synthesis

    VIII. Inhibition by Apoenzyme Antibody

    IX. Metals, Chelators, and Metal Complexers

    X. Cyanide

    XI. Pyridoxal-5-Phosphate (Codecarboxylase), Vitamin B6, B6-Deficiency, B6-Antagonists

    XII. Activators, Stabilizers, and Cofactors Other Than B6-P04

    XIII. Carbonyl Reagents and Inhibitors Acting on Coenzyme Other Than Cyanide, Substrate Analogues, and Pyridoxine Antagonists

    XIV. Hormones

    XV. Miscellaneous

    XVI. Substrate Analogues


    Chapter 10 Inhibitors, Antagonists, and Inactivators in the Etiology of Diabetes Mellitus in Man

    I. Introduction

    II. Insulinogenesis

    III. Release of Insulin

    IV. Impairment of Insulinogenesis

    V. Impairment of Insulin Release

    VI. Impairment in Transport of Insulin

    VII. Inhibitors of Insulin

    VIII. Impairment of Insulin Receptor Sites

    IX. Antagonists of Action of Insulin

    X. Excretion of Insulin

    XI. Degradation of Insulin

    XII. Inhibitors of Insulin Degradation

    XIII. Summary


    Chapter 11 Antagonists and Inhibitors of the Fat-soluble Vitamins

    I. Vitamin A

    II. Vitamin D

    III. Vitamin Ε

    IV. Vitamin Κ


    Chapter 12 Antimetabolites of the Water-soluble Vitamins

    I. General Principles of Antimetabolite Action

    II. Antimetabolites of Water-soluble Vitamins


    Chapter 13 Sulfonamides and Folic Acid Antagonists

    I. Introduction

    II. Sulfonamides

    III. Folic Acid in Enzymic Reactions

    IV. Folic Acid Antagonists


    Chapter 14 Thyroxine Analogues

    I. Introduction

    II. Techniques of Evaluating Thyroxine Inhibitors

    III. Early Studies of Compounds Related to Diiodotyrosine

    IV. Ethers of Diiodotyrosine and Related Compounds

    V. Derivatives of Diiodohydroxybenzoic Acid

    VI. Iodinated Phenoxyacetic Acids

    VII. Partially Iodinated Thyronines and Related Compounds

    VIII. General Survey of Inhibitory Structures


    Chapter 15 Inhibitors of Steroid Actions and Cholesterol and Steroid Biosynthesis

    I. Introduction

    II. Inhibition of Estrogenic Activity

    III. Inhibition of Androgenic Activity

    IV. Inhibition of Corticoid Activity

    V. Inhibition of Steroid Biosynthesis

    VI. Inhibition of Cholesterol Biosynthesis ·


    Author Index

    Subject Index

Product details

  • No. of pages: 690
  • Language: English
  • Copyright: © Academic Press 1963
  • Published: January 1, 1963
  • Imprint: Academic Press
  • eBook ISBN: 9780323143387

About the Editor

R Hochster

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