Metabolic Conjugation and Metabolic Hydrolysis - 1st Edition - ISBN: 9780122576027, 9780323143080

Metabolic Conjugation and Metabolic Hydrolysis

1st Edition

Editors: William Fishman
eBook ISBN: 9780323143080
Imprint: Academic Press
Published Date: 1st January 1970
Page Count: 712
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Metabolic Conjugation and Metabolic Hydrolysis, Volume II, provides an extension and further development of the themes introduced in Volume I in which the subject matter dealt either separately or in combination with the compound undergoing conjugation, the conjugate itself, the conjugating radical, and enzymic hydrolysis of the conjugate. Increased attention is also given to systems in which metabolic conjugation and metabolic hydrolysis interdigitate with each other. The book begins with studies on the role of conjugation in the biliary excretion of organic compounds; cholic acid and its conjugation; biliary secretion and intestinal metabolism and absorption; and the metabolic conjugation and hydrolysis of steroids and their conjugates, as observed in the fetoplacental unit of human pregnancy. Subsequent chapters cover the fabrication through physiological metabolic conjugation of macromolecules of glycoproteins and mucopolysaccharides; the biosynthesis of glycolipids (sphingolipids); the metabolic hydrolysis of hexosaminide linkages; ß-glucuronidases; the hydrolysis of sphingolipids; and mercapturic acid formation.

Table of Contents

List of Contributors


Contents of Volume I

Factors in the Biliary Excretion of Organic Compounds

I. Introduction

II. Chemical Factors

III. Biological Factors


Bile Acid Conjugation

I. Introduction

II. Biosynthesis of Bile Acid Conjugates

III. Determination of Bile Acid Conjugate Synthesis

IV. Factors Influencing Bile Acid Conjugation

V. Physiological Role of Bile Acid Conjugates

VI. Bile Acid Conjugation in Diseases Affecting the Liver

VII. Concluding Remarks


Metabolic Conjugation and Hydrolysis of Estrogens and Progesterone in the Enterohepatic Circulation

I. Introduction

II. Variations in Biliary Excretion and Enterohepatic Circulation of Steroids

III. Nature of Steroid Conjugates Formed in the Liver and Excreted in the Bile

IV. Hydrolysis of Steroid Conjugates in the Intestine

V. Conjugation and Absorption in the Intestine

VI. Concluding Remarks


Metabolic Conjugation and Hydrolysis of Steroid Hormones in the Fetoplacental Unit

I. Introduction

II. Nomenclature and Abbreviations

III. Biosynthesis, Transformation, and Hydrolysis of Steroid Conjugates in the Fetoplacental Unit

IV. Isolation of Steroid Conjugates in the Different Fetal and Placental Tissues

V. Transfer of Steroid Conjugates between the Fetus and the Placenta and between the Placenta and the Mother

VI. Production of Free and Conjugated Steroids during Pregnancy as Compared to Normal Adults and Transformation of Steroid Conjugates during Pregnancy

VII. Steroid Conjugates and Their Transformation in Newborns

VIII. Localization of Sulfuryl- and Glucuronyltransferase and Other Enzymic Systems in the Fetus Compared to Adults and Control of the Production of Steroid Conjugates in Fetal Life

IX. Physiological Significance of Steroid Conjugates during Fetal Life

X. Concluding Remarks


Biochemistry of Mercapturic Acid Formation

I. Introduction

II. Scope of Mercapturic Acid Formation

III. Nutritional Aspects of Mercapturic Acid Formation

IV. Premercapturic Acids

V. Determination of Mercapturic Acids

VI. Mechanism of Mercapturic Acid Formation

VII. Metabolic Degradation of Mercapturic Acids


Metabolic Hydrolysis of Collagen

I. Introduction

II. Structure of Collagen

III. Soluble Collagen Chemistry

IV. Biosynthesis of Collagen

V. Degradation of Collagen

VI. Summary


Biosynthesis of Acidic Glycosaminoglycans (Mucopolysaccharides)

I. Introduction

II. Chemical Structure

III. Biosynthesis of Precursors

IV. Biosynthesis of Chondroitin Sulfate: A Model for the Assembly of Polysaccharide Chains

V. Biosynthesis of Other Glycosaminoglycans

VI. Regulation of Glycosaminoglycan Synthesis


The Metabolic Hydrolysis of Hexosaminide Linkages

I. Introduction

II. Biological Materials Containing Hexosamine Moieties

III. Enzymes Known to Bring About the Hydrolysis of Hexosaminide Linkages

IV. Enzymic Hydrolysis of Hexosaminide Linkages

V. Concluding Remarks


β-Glucuronidases in Metabolic Hydrolysis

I. Introduction

II. History of ß-Glucuronidase

III. Distribution

IV. Factors Which Alter ß-Glucuronidase in Tissues

V. Intracellular Redistribution of ß-Glucuronidase Activity

VI. Factors Which Influence β-Glucuronidase in Body Fluids

VII. Relation of β-Glucuronidase to Diseases

VIII. Genetics

IX. Purification of β-Glucuronidase

X. Properties

XI. Discussion

XII. Summary


Biosynthesis and Hydrolysis of Sphingolipids

I. Introduction

II. Sphingosine

III. Ceramide

IV. Ceramide Galactoside

V. Cerebroside Sulfate (Ceramide Galactoside 4-Sulfate, Sulfatide)

VI. Ceramide Glucoside

VII. Ceramide Lactoside

VIII. Ceramide Trihexoside

IX. Asialo Tay-Sachs Ganglioside (Aminoglycolipid)

X. Hematoside

XI. Tay-Sachs Ganglioside

XII. Monosialogangliosides

XIII. Disialoganglioside

XIV. Sphingomyelin

XV. General Comments


Author Index

Subject Index


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© Academic Press 1970
Academic Press
eBook ISBN:

About the Editor

William Fishman

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