Metabolic Conjugation and Metabolic Hydrolysis

Metabolic Conjugation and Metabolic Hydrolysis

1st Edition - January 1, 1970

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  • Editor: William Fishman
  • eBook ISBN: 9780323143080

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Metabolic Conjugation and Metabolic Hydrolysis, Volume II, provides an extension and further development of the themes introduced in Volume I in which the subject matter dealt either separately or in combination with the compound undergoing conjugation, the conjugate itself, the conjugating radical, and enzymic hydrolysis of the conjugate. Increased attention is also given to systems in which metabolic conjugation and metabolic hydrolysis interdigitate with each other. The book begins with studies on the role of conjugation in the biliary excretion of organic compounds; cholic acid and its conjugation; biliary secretion and intestinal metabolism and absorption; and the metabolic conjugation and hydrolysis of steroids and their conjugates, as observed in the fetoplacental unit of human pregnancy. Subsequent chapters cover the fabrication through physiological metabolic conjugation of macromolecules of glycoproteins and mucopolysaccharides; the biosynthesis of glycolipids (sphingolipids); the metabolic hydrolysis of hexosaminide linkages; ß-glucuronidases; the hydrolysis of sphingolipids; and mercapturic acid formation.

Table of Contents

  • List of Contributors


    Contents of Volume I

    Factors in the Biliary Excretion of Organic Compounds

    I. Introduction

    II. Chemical Factors

    III. Biological Factors


    Bile Acid Conjugation

    I. Introduction

    II. Biosynthesis of Bile Acid Conjugates

    III. Determination of Bile Acid Conjugate Synthesis

    IV. Factors Influencing Bile Acid Conjugation

    V. Physiological Role of Bile Acid Conjugates

    VI. Bile Acid Conjugation in Diseases Affecting the Liver

    VII. Concluding Remarks


    Metabolic Conjugation and Hydrolysis of Estrogens and Progesterone in the Enterohepatic Circulation

    I. Introduction

    II. Variations in Biliary Excretion and Enterohepatic Circulation of Steroids

    III. Nature of Steroid Conjugates Formed in the Liver and Excreted in the Bile

    IV. Hydrolysis of Steroid Conjugates in the Intestine

    V. Conjugation and Absorption in the Intestine

    VI. Concluding Remarks


    Metabolic Conjugation and Hydrolysis of Steroid Hormones in the Fetoplacental Unit

    I. Introduction

    II. Nomenclature and Abbreviations

    III. Biosynthesis, Transformation, and Hydrolysis of Steroid Conjugates in the Fetoplacental Unit

    IV. Isolation of Steroid Conjugates in the Different Fetal and Placental Tissues

    V. Transfer of Steroid Conjugates between the Fetus and the Placenta and between the Placenta and the Mother

    VI. Production of Free and Conjugated Steroids during Pregnancy as Compared to Normal Adults and Transformation of Steroid Conjugates during Pregnancy

    VII. Steroid Conjugates and Their Transformation in Newborns

    VIII. Localization of Sulfuryl- and Glucuronyltransferase and Other Enzymic Systems in the Fetus Compared to Adults and Control of the Production of Steroid Conjugates in Fetal Life

    IX. Physiological Significance of Steroid Conjugates during Fetal Life

    X. Concluding Remarks


    Biochemistry of Mercapturic Acid Formation

    I. Introduction

    II. Scope of Mercapturic Acid Formation

    III. Nutritional Aspects of Mercapturic Acid Formation

    IV. Premercapturic Acids

    V. Determination of Mercapturic Acids

    VI. Mechanism of Mercapturic Acid Formation

    VII. Metabolic Degradation of Mercapturic Acids


    Metabolic Hydrolysis of Collagen

    I. Introduction

    II. Structure of Collagen

    III. Soluble Collagen Chemistry

    IV. Biosynthesis of Collagen

    V. Degradation of Collagen

    VI. Summary


    Biosynthesis of Acidic Glycosaminoglycans (Mucopolysaccharides)

    I. Introduction

    II. Chemical Structure

    III. Biosynthesis of Precursors

    IV. Biosynthesis of Chondroitin Sulfate: A Model for the Assembly of Polysaccharide Chains

    V. Biosynthesis of Other Glycosaminoglycans

    VI. Regulation of Glycosaminoglycan Synthesis


    The Metabolic Hydrolysis of Hexosaminide Linkages

    I. Introduction

    II. Biological Materials Containing Hexosamine Moieties

    III. Enzymes Known to Bring About the Hydrolysis of Hexosaminide Linkages

    IV. Enzymic Hydrolysis of Hexosaminide Linkages

    V. Concluding Remarks


    β-Glucuronidases in Metabolic Hydrolysis

    I. Introduction

    II. History of ß-Glucuronidase

    III. Distribution

    IV. Factors Which Alter ß-Glucuronidase in Tissues

    V. Intracellular Redistribution of ß-Glucuronidase Activity

    VI. Factors Which Influence β-Glucuronidase in Body Fluids

    VII. Relation of β-Glucuronidase to Diseases

    VIII. Genetics

    IX. Purification of β-Glucuronidase

    X. Properties

    XI. Discussion

    XII. Summary


    Biosynthesis and Hydrolysis of Sphingolipids

    I. Introduction

    II. Sphingosine

    III. Ceramide

    IV. Ceramide Galactoside

    V. Cerebroside Sulfate (Ceramide Galactoside 4-Sulfate, Sulfatide)

    VI. Ceramide Glucoside

    VII. Ceramide Lactoside

    VIII. Ceramide Trihexoside

    IX. Asialo Tay-Sachs Ganglioside (Aminoglycolipid)

    X. Hematoside

    XI. Tay-Sachs Ganglioside

    XII. Monosialogangliosides

    XIII. Disialoganglioside

    XIV. Sphingomyelin

    XV. General Comments


    Author Index

    Subject Index

Product details

  • No. of pages: 712
  • Language: English
  • Copyright: © Academic Press 1970
  • Published: January 1, 1970
  • Imprint: Academic Press
  • eBook ISBN: 9780323143080

About the Editor

William Fishman

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