Metabolic Bone Disease

Metabolic Bone Disease

Volume II

1st Edition - January 1, 1978

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  • Editors: Louis V. Avioli, Stephen M. Krane
  • eBook ISBN: 9781483267920

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Metabolic Bone Disease, Volume II describes the clinical disorders of bone and mineral metabolism characterized by elevated levels of circulating parathyroid hormone. This book emphasizes the relationship between hormonal synthesis, biological activity, and abnormalities in specific clinical syndromes. The metabolism and structure-function relationships of parathyroid hormone and other revealing interactions with specific receptors in target organs are also elaborated in this publication, including a basis for some understanding of the parathyroid hormone and vitamin D-“resistant” states. Other topics discussed include the fundamental considerations of the physiology and biochemistry of parathyroid hormone; pathogenesis of renal osteodystrophy; and metabolic aspects of Paget's disease. This publication also covers the effects of hypercalcemia and normocalcemic disorders of mineral metabolism. This volume is beneficial to clinicians and students concerned with metabolic bone diseases.

Table of Contents

  • List of Contributors


    Contents of Other Volumes

    1 Parathyroid Physiology and Primary Hyperparathyroidism

    I. Introduction

    II. Fundamental Considerations of the Physiology and Biochemistry of Parathyroid Hormone

    III. Primary Hyperparathyroidism


    2 Renal Osteodystrophy

    I. Introduction

    II. Pathogenesis of Renal Osteodystrophy

    III. Clinical and Radiological Correlates

    IV. Soft Tissue Calcification

    V. Dialysis Bone Disease

    VI. The Nature of the Bone Lesions

    VII. Therapeutic Management


    3 Hypoparathyroidism

    I. Postoperative Hypoparathyroidism

    II. Nonsurgical Damage to the Parathyroid Glands

    III. Functional Hypoparathyroidism of Diverse Etiology in the Newborn

    IV. Secondary Hypoparathyroidism Due to Hypercalcemia, with Special Reference to the Newborn Infant of a Hyperparathyroid Mother

    V. Secondary Hypoparathyroidism Due to Hypermagnesemia

    VI. Acquired Metabolic Resistance to Parathyroid Hormone

    VII. Hypoparathyroidism Due to the Secretion of Ineffective Parathyroid Hormone

    VIII. Idiopathic Hypoparathyroidism

    IX. Pseudohypoparathyroidism and Related Disorders

    X. Signs and Symptoms of Hypocalcemia

    XI. Biological Findings

    XII. Treatment

    XIII. Concluding Remarks


    4 The Thyroid Gland in Skeletal and Calcium Metabolism

    I. Introduction

    II. The Thyroid Hormones: T3 and T4

    III. Calcitonin

    IV. Recent Developments


    5 Paget's Disease of Bone

    I. Introduction

    II. Historical Aspects

    III. Incidence and Epidemiology

    IV. Histopathology

    V. Focal Manifestations

    VI. Complications

    VII. Metabolic Aspects of Paget's Disease

    VIII. Systemic Complications and Associated Diseases

    IX. Drug Treatment

    X. Etiology


    6 Disorders of Mineral Metabolism in Malignancy

    I. Introduction

    II. Effects of Hypercalcemia

    III. Clinical Occurrence

    IV. Pathogenesis of Tumor-Associated Hypercalcemia

    V. Treatment of Hypercalemia


    7 Metabolic Bone Disease in Children

    I. Growth and Development of Skeleton

    II. Differential Diagnosis of Hypercalcemia

    III. Differential Diagnosis of Hypocalcemia

    IV. Normocalcemic Disorders of Mineral Metabolism

    V. Bone Disease in Disorders of Renal Function



Product details

  • No. of pages: 734
  • Language: English
  • Copyright: © Academic Press 1978
  • Published: January 1, 1978
  • Imprint: Academic Press
  • eBook ISBN: 9781483267920

About the Editors

Louis V. Avioli

Stephen M. Krane

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