Metabolic Bone Disease

Volume 1

1st Edition - January 1, 1977
Editors: Louis V. Avioli, Stephen M. Krane
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 2 - 1 6 3 1 - 7

Metabolic Bone Disease, Volume I covers the approach to a variety of disorders of mineral metabolism. The book discusses bone metabolism and calcium regulation; kidney function in… Read more

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Metabolic Bone Disease, Volume I covers the approach to a variety of disorders of mineral metabolism. The book discusses bone metabolism and calcium regulation; kidney function in calcium and phosphate metabolism; as well as the role of alkaline phosphatase in metabolic bone disorders. The text also describes the diagnostic value of bone biopsies; the etiology, clinical aspects, therapy, and the main syndromes of vitamin D deficiency, rickets, and osteomalacia; and the pathogenesis and therapy of osteoporosis. The pathogenesis and treatment of nephrolothiasis are also encompassed. Orthopedic doctors, physicians, endocrinologists, and people involved in the research of metabolic bone diseases will find the book invaluable.

List of Contributors

Preface

Contents of Other Volumes

1 Bone Metabolism and Calcium Regulation

I. Introduction

II. General Problem of Calcium Regulation

III. General Description of Skeletal Structure and Function

IV. Distribution and Transport of Calcium and Phosphate

V. Regulation of Bone Formation

VI. Regulation of Bone Resorption

VII. Cellular Calcium Regulation

General References

References

2 Kidney Function in Calcium and Phosphate Metabolism

I. Renal Phosphate Transport

II. Renal Calcium Transport

III. Renal Physiology and the Effects of Parathyroid Hormone and Calcitonin on Electrolyte Homeostasis

References

3 Alkaline Phosphatase and Metabolic Bone Disorders

I. Historical

II. Alkaline Phosphatase and Calcification

III. Localization and Purification of Skeletal Alkaline Phosphatase

IV. Tissue Sources of Circulating Alkaline Phosphatases in Normal and Abnormal Subjects

V. Methods of Assay: Normal Values

VI. The Diagnostic Value of Serum Alkaline Phosphatase Determinations in Skeletal Disorders

VII. Alkaline Phosphatase Elevations in Extraskeletal Disorders

VIII. "Stop-Go" Decisions Based on Serum Alkaline Phosphatase

IX. Acid Phosphatase

X. Conclusions

References

4 The Diagnostic Value of Bone Biopsies

I. Introduction

II. Growth

III. Ossification

IV. Remodeling and Turnover

V. Resorption

VI. Reversal Lines

VII. Formation

VIII. Technical Considerations

IX. Skeletal Variability and the Value of Bone Biopsy

X. Quantitative Values in Biopsy Diagnosis

XI. Bone Changes in Metabolic Bone Disease

XII. Appendix

References

5 Vitamin D, Rickets, and Osteomalacia

I. Introduction

II. Vitamin D and Its Metabolism

III. Etiology, Nomenclature, and Clinical Aspects

IV. Radiological and Laboratory Diagnosis

V. Differential Diagnosis

VI. Therapy

VII. Main Diseases and Syndromes Causing Rickets or Osteomalacia

VIII. Conclusion

References

6 Osteoporosis: Pathogenesis and Therapy

I. Definition

II. Physiological Osteopenia

III. Diagnostic Aids

IV. Classification

References

7 Nephrolithiasis

I. Introduction

II. Types of Stones Found in the Urinary Tract

III. Stone Formation and Growth

IV. Pathogenesis of Recurrent Stone Disease

V. Specific Disease of Bone Associated with Nephrolithiasis

VI. Treatment of Renal Stone Disease

References

Index