1st Edition

Biology and Pathobiology

Print ISBN: 9780124537903
eBook ISBN: 9780080536200
Imprint: Academic Press
Published Date: 24th April 2000
Page Count: 672
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245.00 + applicable tax
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Menopause: Biology and Pathobiology is a comprehensive volume covering all aspects of the biology, anatomy, physiology, pathobiology, and pharmacology of menopause, as well as its diagnosis and management. The book is divided into four sections: Basic Biology, Epidemiology, Menopausal Systems Pathophysiology, and Intervention. Basic Biology covers such fundamentals as ovarian anatomy and physiology, mechanisms of steroid hormone action, chronobiological effects, and premature menopause. Epidemiology includes, among others, chapters on methodology challenges in the study of menopause, how to distinguish the effects of age from those of menopause, and a discussion of the key differences in demographics, environmental factors, and ethnicity in the menopause experience. The Pathophysiology section contains chapters on menopause and its various effects on the body, including sexuality, skin, brain, the cardiovascular system, cancers, and mood. The final section includes detailed chapters on intervention and management techniques, with topics including alternative therapies to hormone replacement, exercise, and estrogens and osteoporosis.

Key Features

  • Well-referenced to allow easy look up of anything related to menopause
  • Presents the latest thinking on basic science and clinical topics
  • Exposes what the current gaps in our knowledge are
  • Presents current expert opinions


Researchers, professionals, and academic clinicians in endocrinology, public health, obstetrics and gynecology, epidemiology, and related desciplines.

Table of Contents

Basic Biology: The Molecular Pharmacology of the Estrogen and Progesterone Receptors. Ovarian Anatomy and Physiology. Regulation of the Hypothalamic-Pituitary-Gonadal Axis: Role of Gonadal Steroids and Implications for the Menopause. Gonadotropins and Menopause: New Markers. Genetic Programming in Ovarian Development and Oogenesis. Neuroendocrine Regulation of the Perimenopause Transition. Changes in Men as They Age: The "Manopause." Premature Ovarian Failure. Perimenopausal Changes in FSH, the Inhibins and the Circulating Steroid Hormone Milieu.

Epidemiology: Methodologic Challenges in the Study of Menopause. SWAN: A Multi-center, Multi-ethnic, Commnity-based Cohort Study of Women and the Menopausal Transition. Demographics, Environmental Influences, Ethnic And International Differences In The Menopausal Experience. Distinguishing the Effects of Age From Those of Menopause.

Menopausal Systems Pathophysiology: Menopausal Hot Flashes. Menopause and Cardiovascular Disease. Insulin Resistance, Body Weight, Obesity, Body Composition and the Menopausal Tradition. Influence of Estrogen on Collagen. The Growth Hormone IGF-I Axis and Menopause. Bone & Calcium. Menopause and the Skin. Estrogen Therapy and the Brain. Gyno-Urinary System. Is There a Relationship Between Menopause and Mood? Immunologic Aspects of Menopause. Cancers. Sexuality.

Intervention: Historical Perspectives. Prevention Trials in Perimenopausal Women and Postmenopausal Women. Estrogens: Different Types, Properties. Pr


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© Academic Press 2000
Academic Press
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"Readers who care for menopause-age women will find ample material on physiology, symptom treatment, and health promotion..." -Mary Ellen Rousseau, Yale College of Nursing for JOURNAL OF PSYCHOSOMATIC RESEARCH (December 2001)