Memory Reconsolidation

Memory Reconsolidation

1st Edition - March 18, 2013

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  • Editor: Cristina Alberini
  • eBook ISBN: 9780123868930
  • Hardcover ISBN: 9780123868923

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As little as 10 years ago, it was believed that memory went from short to long term via one consolidation practice that made that memory intractable. Since then, research has shown that long-term memories can be activated, modified, and reconsolidated in their new form. This research indicates that memories are more dynamic than once believed. And understanding how this process works and helping people to redefine established memories can be clinically useful if those memories lead to problems, as is the case in post-traumatic stress disorder. This book provides a comprehensive overview of research on memory reconsolidation; what this has to say about the formation, storage, and changeability of memory; and the potential applications of this research to treating clinical disorders.

Key Features

  • Presents both neuroscience and psychological research on memory reconsolidation
  • Discusses what findings mean for understanding memory formation, storage, and retrieval
  • Includes treatment applications of these findings


Researchers in neuroscience and cognitive science studying memory

Table of Contents

  • Chapter 1. The Discovery of Memory Reconsolidation

    1.1 A brief history


    Chapter two. The Dynamic Nature of Memory

    2.1 When does reconsolidation occur and what is it doing?

    2.2 Possible links between Reconsolidation and memory maintenance mechanisms

    2.3 Memory malleability phenomena and memory reconsolidation

    2.4 Conclusion


    Chapter 3. Mechanisms and Functions of Hippocampal Memory Reconsolidation

    3.1 Hippocampal memory reconsolidation

    3.2 Reconsolidation at the neurophysiological level

    3.3 Boundary conditions on hippocampal memory reconsolidation

    3.4 Memory reconsolidation updates memories

    3.5 Summary and implications


    Chapter four. Reconsolidation of Pavlovian Conditioned Defense Responses in the Amygdala

    4.1 Amygdala and defense fear conditioning

    4.2 Molecular mechanisms of memory reconsolidation

    4.3 Relationships between memory extinction and reconsolidation processes

    4.4 Organization of fear memory associations

    4.5 Conclusions


    Chapter five. Memory Reconsolidation: Lingering Consolidation and the Dynamic Memory Trace

    5.1 Definitions of memory consolidation and reconsolidation

    5.2 Consolidation and reconsolidation of Single trial inhibitory avoidance conditioning

    5.3 Memory reconsolidation and the passage of time

    5.4 Functions of memory reconsolidation: updating and strengthening

    5.5 Memory strengthening via reconsolidation: mechanisms and potential applications

    5.6 Pharmacological disruption of reconsolidation: weakening pathogenic memories

    5.7 A model for memory reconsolidation in hippocampal-dependent memories


    Chapter six. Memory Reconsolidation Versus Extinction

    6.1 Memory reconsolidation versus consolidation

    6.2 Memory extinction versus consolidation

    6.3 Memory reconsolidation versus extinction: behavioral level

    6.4 Relationship between reconsolidation and extinction at the behavioral level: interaction of two memory phases

    6.5 Relationship between reconsolidation and extinction: anatomical level

    6.6 Relationships between reconsolidation and extinction at the molecular level

    6.7 Parameters affecting memory reconsolidation and extinction

    6.8 Clinical importance of understanding the relationships between reconsolidation and extinction for the treatment of emotional disorders

    6.9 Summary


    Chapter seven. Memory Reconsolidation and Extinction in Invertebrates: Evolutionarily Conserved Characteristics of Memory Reprocessing and Restabilization

    7.1 Introduction

    7.2 Context-Signal memory in the crab Chasmagnathus

    7.3 The parametrical conditions of CSM reconsolidation and extinction

    7.4 Molecular mechanisms involved in reconsolidation and extinction of CSM

    7.5 But what about my mouse?

    7.6 A conserved mechanism


    Chapter eight. Using Reconsolidation and Extinction to Weaken Fear Memories in Animal Models

    8.1 Introduction to fear conditioning

    8.2 Extinction

    8.3 Reconsolidation

    8.4 Behavioral reconsolidation update

    8.5 Conclusion


    Chapter 9. Reconsolidation in Humans

    9.1 Historical antecedents: the dynamic nature of human memory

    9.2 Pharmacological alteration of reconsolidation in humans

    9.3 Behavioral interference of reconsolidation

    9.4 General conclusions


    Chapter ten. Reconsolidation of Declarative Memory

    10.1 Introduction

    10.2 Reconsolidation of a declarative memory in humans

    10.3 Specificity of the reminder structure

    10.4 Labilization-Reconsolidation functions: memory updating and strengthening via the reconsolidation process

    10.5 Future insights using the declarative memory paradigm

    10.6 Conclusions and remarks


    Chapter eleven. Episodic Memory Reconsolidation: An Update

    11.1 The paradigm and basic behavioral effect

    11.2 The special role of spatial context in reactivating and updating memories

    11.3 Non-Spatial reminders for reactivating memory

    11.4 Memory strength and reconsolidation

    11.5 Age of memory and stability of the updated memory

    11.6 Theoretical explanations of the updating effect

    11.7 Where do we go from here?


    Chapter 12. Disrupting Consolidation and Reconsolidation of Human Emotional Memory with Propranolol: A Meta-Analysis

    12.1 Methods

    12.2 Results

    12.3 Discussion

    12.4 Conclusion


    Chapter 13. The Translational Potential of Memory Reconsolidation

    13.1 Introduction

    13.2 Preclinical findings

    13.3 Human memory reconsolidation

    13.4 Practical issues

    13.5 Time

    13.6 Conclusion


    Chapter 14. Memory Reconsolidation, Trace Reassociation and the Freudian Unconscious

    14.1 Different types of unconscious processes

    14.2 Memory traces according to freud

    14.3 Memory traces, consolidation, and reconsolidation according to neuroscience and potential links to psychoanalysis

    14.4 Synaptic plasticity and trace reassociation: a working model for the freudian unconscious

    14.5 Homeostatic processes and somatic states

    14.6 Three distinct mechanisms of the FU

Product details

  • No. of pages: 334
  • Language: English
  • Copyright: © Academic Press 2013
  • Published: March 18, 2013
  • Imprint: Academic Press
  • eBook ISBN: 9780123868930
  • Hardcover ISBN: 9780123868923

About the Editor

Cristina Alberini

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