Membrane Proteins

1st Edition, Volume 128 - January 13, 2022
Editor: Rossen Donev
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 8 9 5 - 7
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 8 9 6 - 4

Membrane Proteins, Volume 128 in the Advances in Protein Chemistry and Structural Biology series highlights new advances in the field, with this new volume presenting interesting c… Read more

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Membrane Proteins, Volume 128 in the Advances in Protein Chemistry and Structural Biology series highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

Cover image
Title page
Table of Contents
Copyright
Contributors
Chapter One: Architects of their own environment: How membrane proteins shape the Gram-negative cell envelope
Abstract
1: Introduction
2: Protein insertion and translocation by the SecYEG complex
3: Outer membrane β-barrel folding at the BAM and TAM complexes
4: Lipoprotein targeting and sorting by the Lol system
5: Synthesis and transport of lipopolysaccharide to the outer membrane
6: The blind spot: Phospholipid synthesis, insertion and trafficking
7: Shaping the cell envelope: Membrane attachment and detachment
8: Membrane protein turnover: AAA + proteases and beyond
9: Sensing membrane defects and maintenance of membrane integrity
10: Conclusion
Chapter Two: Modulation of host cellular responses by gram-negative bacterial porins
Abstract
1: Introduction
2: Structure of gram-negative bacterial porins
3: Functions of the gram-negative bacterial porins
4: Important uses of gram-negative bacterial porins
5: Conclusion
Acknowledgment
Chapter Three: Pore formation by pore forming membrane proteins towards infections
Abstract
1: Introduction
2: PFT mechanism of action and structural classification
3: α-PFTs
4: β-PFTs
5: Conformational switch driven membrane pore formation
6: PFT effects and cellular defense mechanisms
7: Calcium-dependent membrane repair mechanisms
8: Therapeutic development
9: Conclusion
Chapter Four: Transmembrane β-barrel proteins of bacteria: From structure to function
Abstract
1: Introduction
2: Structure of β-barrel proteins
3: Folding and membrane integration of β-barrels
4: Functions of transmembrane β-barrels
5: Evolution of β-barrels
6: Medical relevance of bacterial β-barrel proteins
7: Conclusions and future perspectives
Disclaimer
Chapter Five: Ribosome-membrane crosstalk: Co-translational targeting pathways of proteins across membranes in prokaryotes and eukaryotes
Abstract
1: Introduction
2: Membrane translocation via a conserved channel mechanism
3: Molecular machinery of bacterial protein transport
4: Co-translational protein transport in eukaryotes:
5: Concluding remarks
Acknowledgments
Conflict of interest statement
Author contributions
Chapter Six: Mechanisms of long-distance allosteric couplings in proton-binding membrane transporters
Abstract
1: Introduction
2: Proton sensing and proton transfer in human physiology and disease
3: Titratable protein sidechains in protein environments
4: Protonation-coupled changes in membrane protein structure and dynamics
5: Conclusions
Acknowledgments
Chapter Seven: Structures and functions of the membrane-damaging pore-forming proteins
Abstract
1: Introduction
2: α-PFPs
3: β-PFPs
4: Membrane-attack complex and perforin family
5: Gasdermins
6: PFPs from multicellular eukaryotes
7: Conclusion
Acknowledgments
Chapter Eight: Ganglioside binding domains in proteins: Physiological and pathological mechanisms
Abstract
1: Structural features of gangliosides
2: Membrane localization of gangliosides
3: Molecular interactions: The “NH trick”
4: Flat surfaces and chalices: Same gangliosides, two topologies
5: Ganglioside binding domains (GBDs)
6: Helical GBDs
7: Loop shaped GBDs
8: Large flat GBDs
9: Gangliosides and synapses
10: Gangliosides and bacterial toxins
11: Gangliosides and virus infection
12: Gangliosides and neurodegenerative diseases
13: Conclusion and perspectives
Chapter Nine: Development of enhanced conformational sampling methods to probe the activation landscape of GPCRs
Abstract
1: Introduction
2: Molecular dynamics based methods
3: Discrete conformational sampling methods
4: Future of GPCR conformational sampling is hybrid approaches
Acknowledgments
Chapter Ten: Molecular determinants of GPCR pharmacogenetics: Deconstructing the population variants in β2-adrenergic receptor
Abstract
1: Introduction
2: Computational tools to analyze SNPs in GPCRs
3: An overview of the pharmacogenomics in β2-AR
4: Conclusions
Acknowledgments
Chapter Eleven: The role of membranes in function and dysfunction of intrinsically disordered amyloidogenic proteins
Abstract
1: Introduction
2: Human disease-related, widely known IDPs
3: Association of IDPs with biological membranes
4: Implications of IDP-membrane interactions in physiological functions
5: Pathological implications of IDP-membrane interactions
6: Outlook
Acknowledgments
Conflict of interest statement
Author contributions
Chapter Twelve: Dendritic spine membrane proteome and its alterations in autistic spectrum disorder
Abstract
1: Introduction
2: Molecular architecture of the dendritic spine
3: Cholinergic neurotransmission and nicotinic receptors in dendritic spines
4: Spine alterations in neurological and neuropsychiatric disease
5: Spine dysfunction in autism spectrum disorder
6: Dysfunctional neurotransmission in autistic spectrum disorder
7: Concluding remarks

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Rossen Donev