Membrane Protein-Cytoskeleton Interactions

Membrane Protein-Cytoskeleton Interactions

1st Edition - September 13, 1996

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  • Editor: W. Nelson
  • eBook ISBN: 9780080585147

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The plasma membrane acts as both a boundary and a site of exchange between the outside and the inside of a cell. The cytoskeleton plays essential roles in delineating membrane protein distributions, in defining structural and functional domains in the plasma membrane, and in regulating membrane protein, and ultimately, cell function. This volume reviews the regulation of membrane protein distribution, organization, and function at the plasma membrane by the cytoskeleton. Discussions also include the roles of cytoskeleton in the structural and functional organization of membranes and membrane proteins with emphasis on key problems, the current status of understanding, experimental approaches, and future directions.


Cell biologists, molecular biologists, developmental biologists, neurobiologists, biophysicists, immunologists, and physiologists.

Table of Contents

  • M. Edidin, Getting There is Only Half the Fun.
    K.A. Beck and W.J. Nelson, Once There, Making the Decision to Stay or Leave.
    T.A. Schroer and S.R. Gill, Interactions between Microtubules and Intracellular Membranes: The Roles of Microtubule-Based Motors and Accessory Proteins.
    K.R. Fath and D.R. Burgess, The Role of the Cytoskeleton and Molecular Motors in Transport between the Golgi Complex and Plasma Membrane.
    X. Yao and J.G. Forte, Membrane-Cytoskeleton Interaction in Regulated Exocytosis and Apical Insertion of Vesicles in Epithelial Cells.
    P. Devarajan and J.S. Morrow, The Spectrin Cytoskeleton and Organization of Polarized Epithelial Cell Membranes.
    S. Lambert and V. Bennett, Axonal Ankyrins and Ankyrin-Binding Proteins: Potential Participants in Lateral Membrane Domains and Transcellular Connections at the Node of Ranvier.
    R.R. Dubreuil, Molecular and Genetic Dissection of the Membrane Skeleton in Drosophila.
    M.J. Wheelock, K.A. Knudsen, and K.R. Johnson, Membrane-Cytoskeleton Interactions with Cadherin Cell Adhesion Proteins; Roles of Catenins as Linker Proteins.
    A.P. Kowalczyk and K.J. Green, The Desmosome: A Component System for Adhesion and Intermediate Filament Attachment.
    A.S. Fanning, L.A. Lapierre, A.R. Brecher, and C.M. Van Italie, Protein Interactions in the Tight Junction: The Role of MAGUK Proteins in Regulating Tight Junction Organization and Function.
    G.G. Gayer, J.T. Campanelli, and R.H. Scheller, Regulation of Membrane Protein Organization at the Neuromuscular Junction.
    M. Eigenthaler and S.J. Shattil, Integrin Signaling and the Platelet Cytoskeleton.
    L.Y.W. Bourguignon, Interactions between the Membrane-Cytoskeleton and CD44 during Lymphocyte Signal Transduction and Cell Adhesion.
    E.A. Repasky and J.D. Black, Dynamic Properties of the Lymphocyte Membrane Cytoskeleton: Relationship to Lymphocyte Activation Status, Signal Transduction and Protein KinaseC.
    P.R. Smith and D.J. Benos, Regulation of Epithelial Ion Channel Activity by the Membrane-Cytoskeleton.
    H.F. Cantiello and A.G. Prat, Role of Actin Filament Organization on Ion Channel Activity and Cell Volume Regulation.
    R.B. Doctor, R. Bacallao, and L.J. Mandel, Role of the Cytoskeleton in Membrane Alterations in Ischemic and Anoxic Renal Epithelia.
    Chapter References.
    Subject Index.

Product details

  • No. of pages: 427
  • Language: English
  • Copyright: © Academic Press 1996
  • Published: September 13, 1996
  • Imprint: Academic Press
  • eBook ISBN: 9780080585147

About the Serial Volume Editor

W. Nelson

Affiliations and Expertise

Stanford University School of Medicine, California, U.S.A.

About the Serial Editors

Arnost Kleinzeller

Affiliations and Expertise

University of Pennsylvania School of Medicine, Philadelphia, U.S.A.

Dale Benos

Affiliations and Expertise

Department of Physiology and Biophysics, University of Alabama, Birmingham, USA

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