Description Table of Contents Details Editors

Description

The lipids of cellular membranes not only serve roles in controlling the structure and fluidity of the membrane, but are increasingly recognized for their roles as signalling molecules and modifiers of membrane protein function. Recent studies described in this volume reveal striking changes in membrane lipids during aging and in age-related diseases such as cancer, cardiovascular disease and neurodegenerative disorders. Lipids including inositol phospholipids, cholesterol, sphingolipids and ceramides play important roles in signalling cellular responses to stress and specific stimuli such as growth factors, cytokines and neurotransmitters. One or more of these lipid mediators has been linked to the pathogenesis of age-related diseases.

This book provides a comprehensive review of specific membrane lipid mediators and their roles in aging and age-related disease.

Readership

Neuroscientists, biochemists, cell biologists, cardiologists, neurologists.

Table of Contents

1. Overview: Spatial control of signal transduction by caveolae and lipid rafts (C.J. Fielding). 2. Overview: Membrane lipid peroxidation (K. Montine, J. Quinn, T. Montine). 3. Regulation of invertebrate longevity by inositol phosphate signaling (C. Wolkow). 4. Ceramide-driven stress signals in cancer and aging (P.P. Ruvolo, C. Johnson, W.D. Jarvis). 5. Sphingolipid metabolism and signaling in atherosclerosis (S. Chatterjee, S. Martin). 6. Sphingolipid and ceramide in brain aging, neuronal plasticity and neurodegenerative disorders (M.P. Mattson, R.G. Cutler). 7. The eicosanoid pathway and brain aging (H. Manev, T. Uz). 8. Cellular cholesterol, membrane signaling and disease (J.P. Incardona). 9. Cholesterol, &bgr;-amyloid, and Alzheimer's disease (S. Petanceska, M.A. Pappolla et al.). 10. Phospholipase A2 in the pathogenesis of cardiovascular disease (E. Hurt-Camejo, P. Sartipy et al.). 11. Retinal docosahexaenoic acid, age-related diseases and glaucoma (N.G. Bazan, E. Rodriguez).

Details

No. of pages:
236
Language:
English
Copyright:
© 2003
Published:
Imprint:
Elsevier Science
eBook ISBN:
9780080522500
Print ISBN:
9780444512970
Print ISBN:
9780444547798

About the editor

M.P. Mattson

Affiliations and Expertise

Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center, Baltimore, MD, USA
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