Membrane Glycoproteins

A Review of Structure and Function

1st Edition - January 1, 1976
Author: R. Colin Hughes
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 1 - 6 3 9 6 - 3

Membrane Glycoproteins: A Review of Structure and Function deals with membrane glycoproteins found in biological systems. The book describes the structure and biosynthesis of the… Read more

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Membrane Glycoproteins: A Review of Structure and Function deals with membrane glycoproteins found in biological systems. The book describes the structure and biosynthesis of the glycoproteins in relation to known or postulated functions in membranes. The text opens with an introduction and a topic on detection and distribution of membrane glycoproteins. The book then notes that the isolation of membrane glycoproteins brought by the progress in research and technology of membrane solubilization and purification of the soluble components is now possible. Discussion is also directed to glycoproteins as being integral components of intracellular membranes, and not just located on cell surfaces. Through the structural analysis of glycoproteins produced by the secretory glands, analysis of human blood group antigens is available. Likewise, discoveries are made, explaining that lectins are useful reagents in detecting the type and numbers of glycoproteins found on cellular members. Lectins are likewise being widely used in tests for carbohydrate-containing substances in membrane-mediated processes. The metabolism, growth control, and cell surface reactions of membrane glycoproteins are also explained. The book can serve as a guide for biologists, chemists, biochemists, and academicians interested in the study of membranes or glycoproteins.

1. Introduction: Membranes and Membrane Glycoproteins 2. Detection and Distribution of Membrane Glycoproteins Histochemical Evidence Histochemistry of Isolated Membranes Chemical Evidence Cell Coats, Glycocalyx, 'Fuzz' and Membrane Glycoproteins Molecular Dimensions of Membrane Glycoproteins 3. Isolation of Membrane Glycoproteins Introduction Solubilisation Methods Separation and Purification Methods Polyacrylamide Gel Electrophoresis of Membrane Glycoproteins Erythrocyte Membranes KB Cell Membranes 4. Structure of Membrane Glycoproteins A Model Erythrocyte Membrane Glycoproteins Cytochrome B5 and Cytochrome B5 Reductase Summary and Additional Evidence Surface Labelling of Membrane Glycoproteins 5. Intracellular Membrane Glycoproteins Introduction Sarcoplasmic Reticulum Lysosomes Mitochondria Nuclei Zymogen Granules Milk Fat Globule Membrane 6. Membrane Glycoproteins as Antigens Antigens of The ABO System Antigens of The MN System Strong Histocompatibility Antigens7. Lectins Properties of Lectins Glycoprotein Receptors For Lectins Lectin Cytotoxicity and Selection of Resistant Cells Reaction of Lectins With Cells Lectins as Histochemical Reagents 8. Lymphocyte Membrane Glycoproteins Lymphoid Cells Lymphocyte Membranes Clusters and 'Cap' Formation Biological Implications In Lymphocyte Transformation Transformation of Lymphocytes Induced By Oxidation of Membrane Glycoproteins 9. The Mobility of Membrane Glycoproteins Membrane Fluidity—A General Property of Cells Membrane-Intercalated Particles Cell Agglutination 10. Biosynthesis of Glycoproteins Intermediary Metabolism and Sugar Labelling In Whole Cells Glycosyl Transferases Assembly of Carbohydrate Chains Membrane Flow In Glycoprotein Biosynthesis Fidelity of Glycoprotein Biosynthesis Lipid Intermediates In Glycoprotein Biosynthesis Control of Glycosyl Transferases 11. Metabolism of Membrane Glycoproteins Biosynthesis of Membrane Glycoproteins and Membrane Biogenesis Surface Membrane Turnover 12. Membrane Glycoproteins and Growth Control Cellular Regulation of Membrane Glycoprotein Biosynthesis Regulation of Membrane Glycoprotein Biosynthesis In Neoplastic Cells Membrane Glycoproteins In Cells With Finite Life Span In Culture13. Membrane Glycoproteins and Cell Surface Reactions Surface Located Enzymes of Glycoprotein Metabolism Roles In Adhesion Roles In Glycoprotein Catabolism Glycoprotein Structure and The Specificity of Synaptic Connections Appendix A: Terminal Sugar Sequences of Membrane Glycoproteins In Nervous Tissue Appendix B: Glycoprotein Components of Myelin References Index