Membrane Glycoproteins - 1st Edition - ISBN: 9780408707053, 9781483163963

Membrane Glycoproteins

1st Edition

A Review of Structure and Function

Authors: R. Colin Hughes
eBook ISBN: 9781483163963
Imprint: Butterworth-Heinemann
Published Date: 1st January 1976
Page Count: 376
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Membrane Glycoproteins: A Review of Structure and Function deals with membrane glycoproteins found in biological systems. The book describes the structure and biosynthesis of the glycoproteins in relation to known or postulated functions in membranes.
The text opens with an introduction and a topic on detection and distribution of membrane glycoproteins. The book then notes that the isolation of membrane glycoproteins brought by the progress in research and technology of membrane solubilization and purification of the soluble components is now possible. Discussion is also directed to glycoproteins as being integral components of intracellular membranes, and not just located on cell surfaces. Through the structural analysis of glycoproteins produced by the secretory glands, analysis of human blood group antigens is available. Likewise, discoveries are made, explaining that lectins are useful reagents in detecting the type and numbers of glycoproteins found on cellular members. Lectins are likewise being widely used in tests for carbohydrate-containing substances in membrane-mediated processes. The metabolism, growth control, and cell surface reactions of membrane glycoproteins are also explained.
The book can serve as a guide for biologists, chemists, biochemists, and academicians interested in the study of membranes or glycoproteins.

Table of Contents

1. Introduction: Membranes and Membrane Glycoproteins

2. Detection and Distribution of Membrane Glycoproteins

Histochemical Evidence

Histochemistry of Isolated Membranes

Chemical Evidence

Cell Coats, Glycocalyx, 'Fuzz' and Membrane Glycoproteins

Molecular Dimensions of Membrane Glycoproteins

3. Isolation of Membrane Glycoproteins


Solubilisation Methods

Separation and Purification Methods

Polyacrylamide Gel Electrophoresis of Membrane Glycoproteins

Erythrocyte Membranes

KB Cell Membranes

4. Structure of Membrane Glycoproteins

A Model

Erythrocyte Membrane Glycoproteins

Cytochrome B5 and Cytochrome B5 Reductase

Summary and Additional Evidence

Surface Labelling of Membrane Glycoproteins

5. Intracellular Membrane Glycoproteins


Sarcoplasmic Reticulum




Zymogen Granules

Milk Fat Globule Membrane

6. Membrane Glycoproteins as Antigens

Antigens of The ABO System

Antigens of The MN System

Strong Histocompatibility Antigens

7. Lectins

Properties of Lectins

Glycoprotein Receptors For Lectins

Lectin Cytotoxicity and Selection of Resistant Cells

Reaction of Lectins With Cells

Lectins as Histochemical Reagents

8. Lymphocyte Membrane Glycoproteins

Lymphoid Cells

Lymphocyte Membranes

Clusters and 'Cap' Formation

Biological Implications In Lymphocyte Transformation

Transformation of Lymphocytes Induced By Oxidation of Membrane Glycoproteins

9. The Mobility of Membrane Glycoproteins

Membrane Fluidity—A General Property of Cells

Membrane-Intercalated Particles

Cell Agglutination

10. Biosynthesis of Glycoproteins

Intermediary Metabolism and Sugar Labelling In Whole Cells

Glycosyl Transferases

Assembly of Carbohydrate Chains

Membrane Flow In Glycoprotein Biosynthesis

Fidelity of Glycoprotein Biosynthesis

Lipid Intermediates In Glycoprotein Biosynthesis

Control of Glycosyl Transferases

11. Metabolism of Membrane Glycoproteins

Biosynthesis of Membrane Glycoproteins and Membrane Biogenesis

Surface Membrane Turnover

12. Membrane Glycoproteins and Growth Control

Cellular Regulation of Membrane Glycoprotein Biosynthesis

Regulation of Membrane Glycoprotein Biosynthesis In Neoplastic Cells

Membrane Glycoproteins In Cells With Finite Life Span In Culture

13. Membrane Glycoproteins and Cell Surface Reactions

Surface Located Enzymes of Glycoprotein Metabolism

Roles In Adhesion

Roles In Glycoprotein Catabolism

Glycoprotein Structure and The Specificity of Synaptic Connections

Appendix A: Terminal Sugar Sequences of Membrane Glycoproteins In Nervous Tissue

Appendix B: Glycoprotein Components of Myelin




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© Butterworth-Heinemann 1976
eBook ISBN:

About the Author

R. Colin Hughes

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