This volume of Current Topics in Membranes focuses on Membrane Fusion, beginning with fusion and fission of lipid bilayers, with reviews focused on hemifusion and dynamic remodeling of membranes catalyzed by dynamin. Other topics discussed include viral fusion, intracellular fusion, developmental cell fusion, and theoretical modeling.


Researchers in biochemistry, molecular and cellular biology.

Table of Contents

The Pathway to Membrane Fusion through Hemifusion

I. Overview

II. Introduction

III. Criteria and Assays to Identify Hemifusion

IV. Experimental Evidence for Hemifusion

V. Modeling the Biophysical Mechanisms of Hemifusion on the Pathway to Fusion

Dynamic Remodeling of Membranes Catalyzed by Dynamin

I. Overview

II. Introduction

III. Characteristics of Dynamin

IV. Dynamin-Induced Membrane Remodeling

V. Evolution of Models for Dynamin-Catalyzed Membrane Fission

VI. Current Insights from Structural Studies

VII. Future Perspectives


Structure and Working of Viral Fusion Machinery

I. Overview

II. Introduction

III. Structures of Fusion Proteins

IV. Regulation of the Conformational Change

V. Working of the Fusion Machinery

VI. Concluding Remarks


Membrane Fusion Mediated by Human Immunodeficiency Virus Envelope Glycoprotein

I. Introduction

II. HIV Assembly and Structure

III. Structural Changes in HIV Env Leading to Membrane Fusion

IV. What Drives the Enlargement of Fusion Pores?

V. HIV Entry Pathways

VI. Concluding Remarks


The Reovirus Fusion-Associated Small Transmembrane (FAST) Proteins: Virus-Encoded Cellular Fusogens

I. Overview

II. Introduction

III. The Diversity of Fast Proteins

IV. The Fast Proteins are Necessary and Sufficient to Induce Membrane Fusion

V. The Fast Proteins and Prefusion Events

VI. The Fast Proteins and Membrane Merger

VII. The Fast Proteins and Postfusion Events

VIII. Model of the Fast Protein-Mediated Cell–Cell Fusion Reaction

IX. Summary and Future Directions


C2 Domains and Membrane Fusion

I. Overview

II. Membrane F


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© 2011
Academic Press
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