Membrane Fusion

Membrane Fusion

1st Edition - July 25, 2011

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  • Editors: Leonid Chernomordik, Michael Kozlov
  • eBook ISBN: 9780123858924
  • Hardcover ISBN: 9780123858917

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Description

This volume of Current Topics in Membranes focuses on Membrane Fusion, beginning with fusion and fission of lipid bilayers, with reviews focused on hemifusion and dynamic remodeling of membranes catalyzed by dynamin. Other topics discussed include viral fusion, intracellular fusion, developmental cell fusion, and theoretical modeling.

Readership

Researchers in biochemistry, molecular and cellular biology.

Table of Contents

  • The Pathway to Membrane Fusion through Hemifusion

    I. Overview

    II. Introduction

    III. Criteria and Assays to Identify Hemifusion

    IV. Experimental Evidence for Hemifusion

    V. Modeling the Biophysical Mechanisms of Hemifusion on the Pathway to Fusion

    Dynamic Remodeling of Membranes Catalyzed by Dynamin

    I. Overview

    II. Introduction

    III. Characteristics of Dynamin

    IV. Dynamin-Induced Membrane Remodeling

    V. Evolution of Models for Dynamin-Catalyzed Membrane Fission

    VI. Current Insights from Structural Studies

    VII. Future Perspectives

    Acknowledgments

    Structure and Working of Viral Fusion Machinery

    I. Overview

    II. Introduction

    III. Structures of Fusion Proteins

    IV. Regulation of the Conformational Change

    V. Working of the Fusion Machinery

    VI. Concluding Remarks

    Acknowledgments

    Membrane Fusion Mediated by Human Immunodeficiency Virus Envelope Glycoprotein

    I. Introduction

    II. HIV Assembly and Structure

    III. Structural Changes in HIV Env Leading to Membrane Fusion

    IV. What Drives the Enlargement of Fusion Pores?

    V. HIV Entry Pathways

    VI. Concluding Remarks

    Acknowledgment

    The Reovirus Fusion-Associated Small Transmembrane (FAST) Proteins: Virus-Encoded Cellular Fusogens

    I. Overview

    II. Introduction

    III. The Diversity of Fast Proteins

    IV. The Fast Proteins are Necessary and Sufficient to Induce Membrane Fusion

    V. The Fast Proteins and Prefusion Events

    VI. The Fast Proteins and Membrane Merger

    VII. The Fast Proteins and Postfusion Events

    VIII. Model of the Fast Protein-Mediated Cell–Cell Fusion Reaction

    IX. Summary and Future Directions

    Abbreviations

    C2 Domains and Membrane Fusion

    I. Overview

    II. Membrane Fusion

    III. The Molecular Machinery Mediating Calcium-Dependent Membrane Fusion

    IV. Conclusion

    Chasing the Trails of SNAREs and Lipids Along the Membrane Fusion Pathway

    I. Overview

    II. Introduction

    III. Snare-Dependent Membrane Fusion

    IV. Small Molecules as Interrogators for SNARE-Mediated Membrane Fusion

    V. Single Molecule (or Particle) Fluorescence Techniques to Study SNARE-Mediated Membrane Fusion

    Inferring Structures of Kinetic Intermediates in Ca2+-Triggered Exocytosis

    I. Overview

    II. Introduction

    III. Hypothetical Intermediates

    IV. Lipid Contact

    V. Fluid Contact

    VI. Hydrocarbon–Water Contact

    VII. Membrane Bending

    VIII. Role of Proteins

    IX. Conclusion

    Eukaryotic Cell–Cell Fusion Families

    I. Overview

    II. Introduction

    III. Choosing a Model System: C. Elegans as an Organism to Study Cell–Cell Fusion

    IV. Syncytins: an Expanding Metazoan Fusion Family

    V. Regulation of Cell–Cell Fusion in Nematodes and Mammals

    VI. Concluding Remarks

    Invasive Podosomes and Myoblast Fusion

    I. Overview

    II. Introduction

    III. Myoblast Fusion in Vertebrates

    IV. Drosophila as A Model System to Study Myoblast Fusion

    V. Myoblast Fusion in Drosophila

    VI. Relevance to Vertebrate Myoblast Fusion

    VII. Concluding Remarks

    Acknowledgments

    Lipid Acrobatics in the Membrane Fusion Arena

    I. Overview

    II. Introduction

    III. Historical Background

    IV. Fusion Pathways at the Molecular Level

    V. Energy Landscape Along the Fusion Pathway

    VI. Fission Pathways in Molecular Detail

    VII. Peptide Modulated Fusion

    VII. Outlook

    Acknowledgments

    An Alternate Path for Fusion and its Exploration by Field-Theoretic Means

    I. Overview

    II. Introduction

    III. A Different Pathway to Fusion

    IV. Results from A Field-Theoretic Description

    V. Outlook

    VI. Conclusion

    Acknowledgments

Product details

  • No. of pages: 368
  • Language: English
  • Copyright: © Academic Press 2011
  • Published: July 25, 2011
  • Imprint: Academic Press
  • eBook ISBN: 9780123858924
  • Hardcover ISBN: 9780123858917

About the Series Volume Editors

Leonid Chernomordik

Michael Kozlov

Michael Kozlov

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