Membrane Biogenesis and Protein Targetting

Membrane Biogenesis and Protein Targetting

1st Edition - December 9, 1992

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  • Editors: W. Neupert, R. Lill
  • eBook ISBN: 9780080860824

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This book provides a comprehensive overview of recent developments in the fast moving field of protein transport across and into intracellular membranes. The soluble and membrane-bound components assisting in these processes are introduced, and their functions described. Besides a detailed analysis of protein translocation across the bacterial plasma membrane, the mechanisms of protein targeting within the eukaryotic cell are discussed with special focus on the transport of proteins to the endoplasmic reticulum, vacuoles, peroxisomes, mitochondria, and chloroplasts.Providing stimulating hypotheses and models, the book is well suited for advanced students, graduate students, and for newcomers to the field seeking a general, yet accurate introduction to present knowledge in membrane transport of proteins.

Table of Contents

  • Part A. Bacteria 1. Where are we in the exploration of Escherichia coli translocation
    pathways? (B. Wickner). 2. Components involved in bacterial protein
    translocation (C. Harris, P.C. Tai). 3. Molecular characterization of Sec proteins
    comprising the protein secretory machinery of Escherichia coli (S. Mizushima,
    H. Tokuda, S. Matsuyama). 4. Distinct steps in the insertion pathway of
    bacteriophage coat proteins (A. Kuhn, D. Troschel). 5. Steps in the assembly of a
    cytoplasmic membrane protein - The MalF component of the maltose transport
    complex (B. Traxler, J. Beckwith). 6. Structural characteristics of presecretory
    proteins: Their implication as to translocation competency (S. Mizushima, K. Tani,
    C. Hikita, M. Kato). 7. Sequence determinants of membrane protein topology
    (G. von Heijne). 8. Lipid involvement in protein translocation (B. de Kruijff,
    E. Breukink, R.A. Demel, R. van 't Hof, H.H.J. de Jongh, W. Jordi, R.C.A. Keller, J.A. Killian, A.I.P.M. de Kroon, R. Kusters,
    M. Pilon). Part B. Endoplasmic reticulum 9. Membrane protein insertion into the
    endoplasmic reticulum - signals, machinery, and mechanisms (S. High,
    B. Dobberstein). 10. Translocation of proteins through the endoplasmic reticulum membrane:
    investigation of their molecular environment by crosslinking (E. Hartmann,
    T.A. Rapoport). 11. The role of GTP in protein targeting to the endoplasmic
    reticulum (C. Ogg, J.M. Nunnari, J.D. Miller, P. Walter). 12. Consecutive steps of nucleoside
    triphosphate hydrolysis are driving transport of precursor proteins into the
    endoplasmic reticulum (P. Klappa, G. Müller, G. Schlenstedt, H. Wiech, R. Zimmermann).
    Part C. Vacuoles 13. Mechanisms and regulation of import and degradation of
    cytosolic proteins in the lysosome/vacuole (H.-L. Chiang, R. Schekman). 14. The sorting
    of soluble and integral membrane proteins to the yeast vacuole (C.K. Raymond,
    C.A. Vater, S. Nothwehr, C.J. Roberts, T.H. Stevens). Part D. Peroxisomes 15. Defining
    components required for peroxisome assembly in Saccharomyces cerevisiae
    (J. Höhfeld, D. Mertens, F.F. Wiebel, W.-H. Kunau). 16. Structure and assembly of
    peroxisomal membrane proteins (J.M. Goodman, L.J. Garrard, M.T. McCammon). 17. Mechanisms of
    transport of proteins into microbodies (S. Subramani). 18. Lessons for peroxisome
    biogenesis from fluorescence analyses of Zellweger syndrome fibroblasts
    (P.B. Lazarow, H.W. Moser, M.J. Santos). Part E. Mitochondria 19. The mitochondrial protein
    import machinery of Saccharomyces cerevisiae (V. Hines). 20. Protein insertion
    into mitochondrial outer and inner membranes via the stop-transfer sorting
    pathway (G.C. Shore, D.G. Millar, J.-M. Li). 21. General and exceptional pathways of protein
    import into sub-mitochondrial compartments (R. Lill, C. Hergersberg, H. Schneider,
    T. Söllner, R. Stuart, W. Neupert). Part F. Cloroplasts 22. Targeting of
    proteins into and across the chloroplast envelope (H.-M. Li, S.E. Perry, K. Keegstra). 23.
    Transport of proteins into the thylakoids of higher plant chloroplasts (C. Robinson).
    24. Comparison of two different protein translocation mechanisms into
    chloroplasts (J. Soll, H. Alefsen, B. Böckler, B. Kerber, M. Salomon, K. Waegemann). Part G.
    25. DnaJ homologs and protein transport (T. Kurihara, P.A. Silver). 26.
    Chaperonin-mediated protein folding (A.L. Horwich, S. Caplan, J.S. Wall, F.-U.Hartl). References. Index.

Product details

  • No. of pages: 340
  • Language: English
  • Copyright: © Elsevier Science 1992
  • Published: December 9, 1992
  • Imprint: Elsevier Science
  • eBook ISBN: 9780080860824

About the Editors

W. Neupert

R. Lill

Affiliations and Expertise

Institut fur Physiologische Chemie, Physikalische Biochemie und Zelbiologie der Ludwig-Maximillans-Universitat Munchen, Goetherstrasse 33, D-8000 Munchen 2, Germany

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