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Membrane Biogenesis and Protein Targetting - 1st Edition - ISBN: 9780444896384, 9780080860824

Membrane Biogenesis and Protein Targetting, Volume 22

1st Edition

Editors: W. Neupert R. Lill
eBook ISBN: 9780080860824
Imprint: Elsevier Science
Published Date: 9th December 1992
Page Count: 340
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Table of Contents

Part A. Bacteria 1. Where are we in the exploration of Escherichia coli translocation
pathways? (B. Wickner). 2. Components involved in bacterial protein
translocation (C. Harris, P.C. Tai). 3. Molecular characterization of Sec proteins
comprising the protein secretory machinery of Escherichia coli (S. Mizushima,
H. Tokuda, S. Matsuyama). 4. Distinct steps in the insertion pathway of
bacteriophage coat proteins (A. Kuhn, D. Troschel). 5. Steps in the assembly of a
cytoplasmic membrane protein - The MalF component of the maltose transport
complex (B. Traxler, J. Beckwith). 6. Structural characteristics of presecretory
proteins: Their implication as to translocation competency (S. Mizushima, K. Tani,
C. Hikita, M. Kato). 7. Sequence determinants of membrane protein topology
(G. von Heijne). 8. Lipid involvement in protein translocation (B. de Kruijff,
E. Breukink, R.A. Demel, R. van 't Hof, H.H.J. de Jongh, W. Jordi, R.C.A. Keller, J.A. Killian, A.I.P.M. de Kroon, R. Kusters,
M. Pilon). Part B. Endoplasmic reticulum 9. Membrane protein insertion into the
endoplasmic reticulum - signals, machinery, and mechanisms (S. High,
B. Dobberstein). 10. Translocation of proteins through the endoplasmic reticulum membrane:
investigation of their molecular environment by crosslinking (E. Hartmann,
T.A. Rapoport). 11. The role of GTP in protein targeting to the endoplasmic
reticulum (C. Ogg, J.M. Nunnari, J.D. Miller, P. Walter). 12. Consecutive steps of nucleoside
triphosphate hydrolysis are driving transport of precursor proteins into the
endoplasmic reticulum (P. Klappa, G. Müller, G. Schlenstedt, H. Wiech, R. Zimmermann).
Part C. Vacuoles 13. Mechanisms and regulation of import and degradation of
cytosolic proteins in the lysosome/vacuole (H.-L. Chiang, R. Schekman). 14. The sorting
of soluble and integral membrane proteins to the yeast vacuole (C.K. Raymond,
C.A. Vater, S. Nothwehr, C.J. Roberts, T.H. Stevens). Part D. Peroxisomes 15. Defining
components required for peroxisome assembly in Saccharomyces cerevisiae
(J. Höhfeld, D. Mertens, F.F. Wiebel, W.-H. Kunau). 16. Structure and assembly of
peroxisomal membrane proteins (J.M. Goodman, L.J. Garrard, M.T. McCammon). 17. Mechanisms of
transport of proteins into microbodies (S. Subramani). 18. Lessons for peroxisome
biogenesis from fluorescence analyses of Zellweger syndrome fibroblasts
(P.B. Lazarow, H.W. Moser, M.J. Santos). Part E. Mitochondria 19. The mitochondrial protein
import machinery of Saccharomyces cerevisiae (V. Hines). 20. Protein insertion
into mitochondrial outer and inner membranes via the stop-transfer sorting
pathway (G.C. Shore, D.G. Millar, J.-M. Li). 21. General and exceptional pathways of protein
import into sub-mitochondrial compartments (R. Lill, C. Hergersberg, H. Schneider,
T. Söllner, R. Stuart, W. Neupert). Part F. Cloroplasts 22. Targeting of
proteins into and across the chloroplast envelope (H.-M. Li, S.E. Perry, K. Keegstra). 23.
Transport of proteins into the thylakoids of higher plant chloroplasts (C. Robinson).
24. Comparison of two different protein translocation mechanisms into
chloroplasts (J. Soll, H. Alefsen, B. Böckler, B. Kerber, M. Salomon, K. Waegemann). Part G.
25. DnaJ homologs and protein transport (T. Kurihara, P.A. Silver). 26.
Chaperonin-mediated protein folding (A.L. Horwich, S. Caplan, J.S. Wall, F.-U.Hartl). References. Index.


This book provides a comprehensive overview of recent developments in the fast moving field of protein transport across and into intracellular membranes. The soluble and membrane-bound components assisting in these processes are introduced, and their functions described. Besides a detailed analysis of protein translocation across the bacterial plasma membrane, the mechanisms of protein targeting within the eukaryotic cell are discussed with special focus on the transport of proteins to the endoplasmic reticulum, vacuoles, peroxisomes, mitochondria, and chloroplasts.

Providing stimulating hypotheses and models, the book is well suited for advanced students, graduate students, and for newcomers to the field seeking a general, yet accurate introduction to present knowledge in membrane transport of proteins.


No. of pages:
© Elsevier Science 1992
9th December 1992
Elsevier Science
eBook ISBN:

Ratings and Reviews

About the Editors

W. Neupert

R. Lill

Affiliations and Expertise

Institut fur Physiologische Chemie, Physikalische Biochemie und Zelbiologie der Ludwig-Maximillans-Universitat Munchen, Goetherstrasse 33, D-8000 Munchen 2, Germany