Melanoma, An Issue of Clinics in Plastic Surgery

1st Edition, Volume 48-4 - September 9, 2021
Editors: Brian R. Gastman, Michael W. Neumeister
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 8 1 3 2 1 - 1
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 1 3 2 2 - 8

This issue of Clinics in Plastic Surgery, Guest Edited by Drs. Brian R. Gastman and Michael W. Neumeister, is dedicated to Melanoma. This issue is one of four selected each year.… Read more

Melanoma, An Issue of Clinics in Plastic Surgery

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This issue of Clinics in Plastic Surgery, Guest Edited by Drs. Brian R. Gastman and Michael W. Neumeister, is dedicated to Melanoma. This issue is one of four selected each year. Articles in this issue include, but are not limited to: Melanoma risk factors and prevention, Biology and signaling pathways of melanoma, Immunobiology of melanoma, Clinical diagnosis and classification, Histopathologic and molecular diagnosis of melanoma, AJCC staging and other platforms to assess prognosis and risk, Current treatment guidelines of primary melanoma including wide excision and use of sentinel node biopsy, Dermatologic follow-up and assessment of suspicious lesions, Immunotherapy of melanoma, Targeted therapies for melanoma, Non-operative intra-tumoral therapies, Role of radiation for locoregional and distant metastatic melanoma, Adjuvant and neoadjuvant therapy for melanoma, Surgery of the nodal basins for trunk and extremity melanoma, Extirpative considerations of melanoma of the head and neck, Treatment of lentigo melanoma of the head and neck, Reconstructive considerations of melanoma of the head and neck, Melanoma of the hands and feet, Rare variants of melanoma, and Emerging therapies for melanoma.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Melanoma Risk Factors and Prevention
Key points
Introduction
Summary
Clinics care points
Canonical Signaling Pathways in Melanoma
Key points
Introduction
Summary
Immunobiology of Melanoma
Key points
Introduction
Cancer immunoediting and immunosurveillance
Summary
Clinics care points
Clinical Diagnosis and Classification: Including Biopsy Techniques and Noninvasive Imaging
Key points
Introduction
History
Physical examination
ABCDE’s of melanoma
Classification
In-transit metastases
Lymph node examination
Dermoscopy examination
Reflectance confocal microscopy
Computer-based technology
Biopsy
Laboratory testing
Imaging
Discussion
Clinics care points
Histopathologic and Molecular Diagnosis of Melanoma
Key points
Introduction
Histopathology of melanoma
The melanoma report
Problem areas
Immunohistochemistry
Molecular testing
Sentinel lymph node pathology
Summary
Clinics care points
American Joint Committee on Cancer Staging and Other Platforms to Assess Prognosis and Risk
Key points
Introduction
Eighth edition American Joint Committee on Cancer staging system
T category
N category
M category
Prognostic stage groups
Approach to staging patients with multiple primary melanomas
Approach to staging patients after neoadjuvant therapy
Approach to staging patients after recurrence/retreatment
Summary
Clinics care points
Sentinel Lymph Node Biopsy, Lymph Node Dissection, and Lymphedema Management Options in Melanoma
Key points
Introduction
Sentinel lymph node biopsy
Completion lymph node dissection
Lymphedema
Summary
Clinics care points
Dermatologic Follow-up and Assessment of Suspicious Lesions
Key points
Introduction
Background
Current guidelines for melanoma surveillance
Discussion
Summary
Clinics care points
Non-Operative Options for Loco-regional Melanoma
Key points
Introduction
Summary
Clinics care points
Radiation Therapy for Local Cutaneous Melanoma
Key points
Introduction
Summary
Clinics care points
Adjuvant and Neoadjuvant Therapeutics for the Treatment of Cutaneous Melanoma
Key points
Introduction
Immune therapy
Targeted therapy
Oncolytic vaccines
Summary
Clinics care points
Disclosure
Extirpative Considerations of Melanoma of the Head and Neck
Key points
Introduction
Demographics
Risk factors
Types of melanoma in the head and neck
Prognostic factors and survival
Biopsy
Workup
Current staging
Surgical treatment
Indications for sentinel lymph node investigation
Unique problems of head and neck sentinel node techniques
Treatment of lymph nodes based on sentinel lymph node biopsy
Summary
Clinics care points
Lentigo Maligna
Key points
Introduction
Cause
Epidemiology
Presentation and diagnosis
Prognosis and staging
Treatments
Summary
Clinics care points
Disclosure
Spitz Nevus: Review and Update
Key points
Introduction
Epidemiology
History
Clinical presentation
Differential diagnosis
Diagnosis
Dermoscopic features
Pathology
Atypical Spitz nevus pathology
Pathologic subtypes of Spitz nevus
Ancillary tests
Molecular studies
Treatment of Spitz nevus
Sentinel lymph node biopsy
Evolution of Spitz nevus
Prognosis
Summary
Clinics care points
Melanoma of the Hands and Feet (With Reconstruction)
Key points
Importance of hand and foot melanoma
Major histologic subtypes of melanoma
Topical distribution
Acral lentiginous melanoma
Subungual melanoma
Amelanotic melanoma
Prognosis of melanoma of the hands and feet
Treatment (surgical management)
Clinics care points
Melanoma in Pregnancy and Pediatrics
Key points
Pregnancy-associated melanoma
Pediatrics melanoma
Clinics care points
Mucosal Melanoma
Key points
Introduction
Summary
Clinics care points
Emerging Therapies in the Treatment of Advanced Melanoma
Key points
Introduction
Immunotherapy
Targeted therapy
Combined immunotherapy and targeted therapy
Intratumoral therapy
Cytokine therapy
Adoptive Cell Therapy
Vaccine therapy
Summary
Clinics care points