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Medicinal Chemistry—III
Main Lectures Presented at the Third International Symposium on Medicinal Chemistry
1st Edition - January 1, 1973
Editor: P. Pratesi
Language: English
eBook ISBN:9781483284743
9 7 8 - 1 - 4 8 3 2 - 8 4 7 4 - 3
Medicinal Chemistry–III provides information pertinent to the fundamental aspects of medicinal chemistry. This book discusses the mechanism of action of drugs at the molecular…Read more
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Medicinal Chemistry–III provides information pertinent to the fundamental aspects of medicinal chemistry. This book discusses the mechanism of action of drugs at the molecular level. Organized into eight chapters, this book begins with an overview of the systems for protein biosynthesis that are classified according to their mechanism and the selective action of drugs on their reactions. This text then examines the key structure in the biosynthesis of the peptidoglycans of bacterial cell walls. Other chapters consider the enzymes that transcribe DNA synthesizing RNA, which have structural differences in eukaryotic and prokaryotic cells. This book discusses as well the concepts for drug screening as they have been emerged from neurochemical research. The final chapter deals with the significance of molecular orbital theory in the hands of the biologist or chemists, which lies in its ability to derive information regarding the properties of molecules. This book is a valuable resource for organic, physical, and biological chemists.
Contents
Opening Remarks
The Mechanisms of Selectivity and Action of Protein Synthesis Inhibitors
The Significance of D-Alanyl-D-Alanine Termini in the Biosynthesis of Bacterial Cell Walls and the Action of Penicillin, Vancomycin and Ristocetin
Inhibitors of the Transcribing Enzymes
Analogues of Cyclic Amp and Their Physiological Response
Principles of Neurochemistry and Drug Screening Procedures in Neuropsychopharmacology
Active Polypeptides of the Amphibian Skin and Their Synthetic Analogues
Some Biological Applications of Regular Solution Theory
The Prediction of Molecular Conformation As A Biologically Significant Property