
Medicinal Chemistry Approaches to Tuberculosis and Trypanosomiasis
Description
Key Features
- Provides an overview of the status of some of the current novel compounds in development as well as new emerging treatment options targeting novel mechanisms of action
- Identification of hits from phenotypic whole cell screening, followed by target identification
- Strategies aimed at improving the efficacy of existing clinically used anti-TB drugs by taking advantage inhibitors of mycobacterial transcriptional regulators to boost the anti-tubercular activity, and circumvent acquired-resistance
Readership
Medicinal chemists, synthetic chemists, biologists, pharmacologists and clinicians
Table of Contents
1. Tuberculosis
Steven J. Berthel, Christopher B. Cooper and Nader P. Fotouhi
2. Antituberculosis agents: Beyond medicinal chemistry rules
Marco Pieroni
3. Development of MmpL3 inhibitors for tuberculosis treatment
Giovanna Poce, Sara Consalvi, Giulia Venditti, Cristina Scarpecci and Mariangela Biava
4. Inhibitors of enzymes in the electron transport chain of Mycobacterium tuberculosis
Andrew M. Thompson and William A. Denny
5. Recent advances in the design of inhibitors of mycobacterial transcriptional regulators to boost thioamides anti-tubercular activity and circumvent acquired-resistance
Nicolas Willand, Marion Flipo, Baptiste Villemagne, Alain Baulard and Benoit Deprez
6. Sustainable anti-trypanosomatid drugs: An aspirational goal for medicinal chemistry
Maria Laura Bolognesi
Product details
- No. of pages: 188
- Language: English
- Copyright: © Academic Press 2019
- Published: September 6, 2019
- Imprint: Academic Press
- eBook ISBN: 9780128175576
- Hardcover ISBN: 9780128175569
About the Serial Volume Editor
Kelly Chibale

Affiliations and Expertise
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