Medical Pharmacology and Therapeutics - 4th Edition - ISBN: 9780702051807, 9780702052255

Medical Pharmacology and Therapeutics

4th Edition

Authors: Derek Waller Tony Sampson
eBook ISBN: 9780702052255
Paperback ISBN: 9780702051807
Imprint: Saunders Ltd.
Published Date: 13th September 2013
Page Count: 744

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2014 BMA Medical Book Awards Highly Commended in Medicine category!

The fourth edition of Medical Pharmacology and Therapeutics provides a complete basis for learning about safe and effective prescribing of modern medicines. It offers all the pharmacology medical students will need - from basic science pharmacology and pathophysiology, through to clinical pharmacology and therapeutics, in line with today’s integrated curricula. The disease-based approach and clear presentation of how drugs are used in clinical practice sets it apart from other texts and helps make it such an invaluable guide for all health professionals from the start of their course until after they have qualified.

This new edition has been extensively revised and updated throughout. Key features include:

■ Succinct explanations of the major pathogenic mechanisms of each disease and consequent clinical signs and symptoms

■ Comprehensive reviews of major drug classes relevant to each disease

■ A structured approach to the principles of disease management - outlining core principles of drug choice and planning a therapeutic regimen for common diseases

■ Quick-reference drug compendia, which illustrate key similarities and differences among drugs in each class

■ New sections on key and evolving topics, including headache and drug treatment in palliative care

■ Re-worked art programme to further clarify complex areas

■ Fully revised self-assessment questions and case-based exercises - to test understanding and aid revision

Key Features

  • Integrates basic science pharmacology, clinical pharmacology and therapeutics
  • Brief review of pathophysiology of major diseases
  • Case histories and self-assessment questions (and answers)
  • Tabular presentation of all common drugs within each class
  • Section on further reading

Table of Contents

General Principles. Principles of pharmacology and mechanisms of drug action. Pharmacokinetics. Drug discovery, safety and efficacy. The nervous system, neurotransmission and the peripheral nervous system.

Cardiovascular system. Ischaemic heart disease. Systemic and pulmonary hypertension. Heart failure. Cardiac arrhythmias. Cerebrovascular disease and dementia. Peripheral vascular disease. Haemostasis.

Respiratory system. Asthma and chronic obstructive pulmonary disease. Other respiratory problems.

Renal system. Diuretics. Disorders of micturition. Erectile dysfunction.

Nervous system. General anaesthetics. Local anaesthetics. Opioid analgesics. Anxiolytics, sedatives and hypnotics. Psychotic disorders. Depression, attention deficit hyperactivity disorder and narcolepsy. Epilepsy. Extrapyramidal movement disorders and spasticity. Other neurological disorers. Migraine.

Musculoskeletal system. Neuromuscular blockade. Myasthenia gravis. NSAIDs. Inflammatory arthritis. Hyperuricaemia and gout.

Gastrointestinal system. Nausea and vomiting. Dyspepsia and peptic ulcer disease. Inflammatory bowel disease. Constipation, diarrhoea and IBS. Obesity.

Immune system. The immune response and immunosuppressant drugs. Antihistamines and allergic disease.

Endocrine system and metabolic disease. Diabetes mellitus. Thyroid disease. Calcium metabolism. Pituitary and hypothalmic hormones. Corticosteroids. Female reproductive system. Androgens and anabolic steroids. Anaemia. Lipids.

Skin and eye disorders. Skin disorders. Eye disorders

Chemotherapy. Chemotherapy of infection. Chemotherapy of malignancy.

Drug toxicity and prescribing. Drug toxicity and overdose. Substance abuse and dependence. Prescribing, adherence and information for patients. Drug therapy in special situations.


No. of pages:
© Saunders Ltd. 2014
Saunders Ltd.
eBook ISBN:
Paperback ISBN:

About the Author

Derek Waller

Affiliations and Expertise

Consultant Cardiovascular Physician, Southampton General Hospital; Senior Lecturer in Medicine and Clinical Pharmacology, University of Southampton, Southampton, UK

Tony Sampson

Affiliations and Expertise

Reader in Clinical Pharmacology, University of Southampton Faculty of Medicine, Southampton, UK


"First of all it is British and so ideal for those of us in the UK...It is also bang up to date..It's laid out in typical textbook style and is organised into general principles and body systems... The text is broken up into digestible chunks and good use is made of colour whilst there is plenty of self assessment to pit your wit against. It is a great book, ideal for undergraduates, but it is also a super reference source for clinicans wanting to brush up their knowledge. It is an ideal adjunct to the BNF."

Glycosmedia, March 2014