Medical Epigenetics

Medical Epigenetics

2nd Edition - August 25, 2021

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  • Editor: Trygve Tollefsbol
  • Paperback ISBN: 9780128239285
  • eBook ISBN: 9780128243268

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Medical Epigenetics, Second Edition provides a comprehensive analysis of epigenetics in health management, across a broad spectrum of disease categories and specialties, and with a focus on human systems, epigenetic diseases that affect these systems, and evolving modes of epigenetic-based treatment. Here, more than 40 leading researchers examine how each human system is affected by epigenetic maladies, offering an all-in-one resource on medical epigenetics not only for those directly involved with health care, but investigators in life sciences, biotech companies, graduate students, and others who are interested in applied aspects of epigenetics. Incorporating both diagnostic and prognostic epigenetic approaches, this volume also fully supports the application of epigenetics in precision medicine. This second edition of Medical Epigenetics, a volume in the Translational Epigenetics series, has been fully revised to address recent advances in disease epigenetics and role of epigenetics in precision medicine, with all-new chapters on skin cancer epigenetics, network analysis in medical epigenetics, machine learning in epigenetic diseases, and clinical trials of epigenetics drugs.

Key Features

  • Features chapters from leading researchers and clinicians dedicated to the burgeoning role of epigenetics in medical practice
  • Covers emerging topics, including twin epigenetics, as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine
  • Organized from system disorders to multi-system disorders that involve epigenetic aberrations
  • Examines the role of epigenetics in precision medicine


Human geneticists; human genomicists; translational researchers in genomic medicine, epigenetics, biochemistry, molecular biology; life science researchers; developmental biologists. Clinicians and graduate students in the biosciences

Table of Contents

  • Section A Overview
    1. Advances in medical epigenetics
    Section B General medical aspects of epigenetics
    2. Environmental epigenetic epidemiology
    3. Lifestyle and preventive medical epigenetics
    4. Environmental medical epigenetics: A review of epigenetically induced medical risks generated from exposures in our air, food, and personal products
    5. Behavioral medical epigenetics
    6. Medical epigenetics and twins
    7. Epigenetic biomarkers of disease
    8. Prognostic epigenetics
    Section C Epigenetics of system disorders
    9. Autoimmune disease and epigenetics
    10. Epigenetics of pulmonary diseases
    11. Cardiovascular disorders and epigenetics
    12. Epigenomics of intestinal disease
    13. Epigenetics of skin disorders
    14. Epigenetics in bone and joint disorders
    15. Epigenetics of muscle disorders
    16. Reproductive disease epigenetics
    17. Epigenetics in ocular medicine
    Section D Multi-system medical epigenetics
    18. Pediatric diseases and epigenetics
    19. Epigenetics of infectious diseases
    20. Clinical utility of solid tumor epigenetics
    21. Epigenetics in acute myeloid leukemia
    22. Epigenetic regulation in cancer metastasis
    23. Epigenetics in exercise science and sports medicine
    Section E Bioinformatics of epigenetic medicine
    24. Machine learning in epigenetic diseases
    Section F Pharmacology of epigenetics
    25. Epigenetics in toxicology and drug development
    26. Pharmacoepigenomics in neurodegenerative diseases
    Section G Therapeutic epigenetics
    27. Therapeutics and DNA methylation inhibitors
    28. Histone deacetylase inhibitors in medical therapeutics
    29. Sirtuins as NAD+-dependent deacetylases and their potential in medical therapy
    30. Experimental approaches toward histone acetyltransferase modulators as therapeutics
    31. Histone methylation modifiers in medical therapeutics
    32. Modulation of noncoding RNAs (ncRNAs) and their potential role as therapeutics
    33. Nutrients and phytonutrients as promising epigenetic nutraceuticals
    34. Epigenetics of pain management
    35. Precision medical epigenetics
    36. Epigenetics and regenerative medicine
    37. Stem cell epigenetics in medical therapy
    38. The clinical landscape of HDAC inhibitors
    Section H Medical epigenetics: Future prospects
    39. Epigenetics: Future prospective in human disorders and therapeutics
    40. Prospective advances in medical epigenetics

Product details

  • No. of pages: 970
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: August 25, 2021
  • Imprint: Academic Press
  • Paperback ISBN: 9780128239285
  • eBook ISBN: 9780128243268

About the Series Volume Editor

Trygve Tollefsbol

Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O’Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.

Affiliations and Expertise

Distinguished Professor of Biology Senior Scientist, O’Neal Comprehensive Cancer Center Senior Scientist, Integrative Center for Aging Research Senior Scientist, Comprehensive Diabetes Center Senior Scientist, Nutrition Obesity Research Center Senior Scientist, University Wide Microbiome Center Director, Cell Senescence Culture Facility University of Alabama at Birmingham, AL, USA

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