Description

The development of liposomes as a drug delivery system has fluctuated since its introduction in the late 1960's by A.D. Bangham. While academic research of liposomes as a model membrane system has always flourished, as the exponential growth of papers can testify, the application of these findings to medically useful products has gone through several crises. Following the original optimism in the 70's and early 80's, a period of severe skepticism ensued at the end of the 80's and beginning of the 90's, culminating in a moderate but real optimism in the mid 90's, as a result of a successful launch of the first products in the US and Europe.

In this collection of papers, the editors have gathered the most promising ideas, approaches, applications and commercial developments, thereby presenting an up-to-date compilation of the present status of the field. This includes such broad areas as anti-cancer chemotherapy immune stimulation and infectious diseases. Currently, the major areas of progress are in delivery of anti-fungal agents by conventional liposomes or lipid-based carriers and systemic anticancer therapy using long-circulating liposomes. The future applications as characterized by the direction of present day research is in specific targeting and delivery of informational molecules such as DNA plasmids (genes), antisense oligonucleotides or ribozymes. Other future developments may be in topical delivery, vaccination and in diagnostics.

Features of this book:

• Contributions from almost all the leading labs in the field

• Up-to-date, critical reviews bridged by editors' introductions

• Organized into a logical framework.

Table of Contents

1. Liposomes in Medicine. General introduction (D.D. Lasic, D. Papahadjopoulos). Liposome research in drug delivery and targeting: Thoughts of an early participant (G. Gregoriadis). 2. Stimulation of Immune Response and Vaccination. Class I presentation of liposomal antigens (M. Rao, C.R. Alving). Major histocompatibility complex Class II molecules, liposomes and antigen presentation (L. Leserman, N. Barois). Systemic activation of macrophages by liposomes containing synthetic immunomodulators for treatment of metastatic disease (L. A. Worth et al.). DNA vaccination: A role for liposomes (G. Gregoriadis et al.). "Virosomes", a new liposome-like vaccine delivery system (R. Glück, A. Wegmann). Liposomes and virosomes as immunoadjuvant and antigen-carrier systems in vaccine formulations (T. Daemen et al.). Theoretical basis for development of liposomes as carriers of vaccines (C.R. Alving). 3. Infectious Diseases. The development of liposomal amphotericin B: An historical perspective (K.M. Wasan, G. Lopez-Berestein). Long-circulating liposomes containing antibacterial and antifungal agents (I.A.J.M. Bakker-Woudenberg, E.W.M. van Etten). Treatment of human immunodeficiency virus mycobacterium avium and mycobacterium tuberculosis infections by liposome-encapsulated drugs (N. Düzgünes). 4. Cancer Therapy. Introduction and general strategies (D.D. Lasic, D. Papahadjopoulos). Designing therapeutically optimized liposomal anticancer delivery systems: Lessons from conventional liposomes (L.D. Mayer et al.). Pharmacologic advantages of anthracyclines encapsulated in poly-ethylene-glycol coated stealth liposomes: Potential for tumor targeting (D. Goren, A. Gabizon). Cellular distribution of Doxil® within selected tissues, assessed by confocal laser scanning microscopy (J. Vaage et al.). Liposomes as carriers of lipophilic antitumor a

Details

No. of pages:
779
Language:
English
Copyright:
© 1998
Published:
Imprint:
Elsevier Science
eBook ISBN:
9780080536088
Print ISBN:
9780444829177
Print ISBN:
9780444543769

About the editors

D.D. Lasic

Affiliations and Expertise

Liposome Consultations, 7512 Birkdale Drive, Newark, CA 94560, USA

D. Papahadjopoulos

Affiliations and Expertise

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143-0450, USA

Reviews

@from:R. Schubert @qu:...chapters do not only show the numerous successes in liposome research, which have resulted in a variety of pharmaceutical products on the market or at least in clinical studies. They all also contain the essential literature, which is indispensable for all scientists interested in this research area.

...Neither editor is alive. D. Papahadjopoulos died in 1998. ...D.D. Lasic, ...died unexpectedly in November 2000. This book with a careful selection of contributions in the large field of liposome research and development is a great legacy of both outstanding liposomologists for all scientists in this fascinating area of research. @source:European Journal of Pharmaceutics and Biopharmaceutics @from:H.G. Brittain @qu:...workers in liposomal research will want to obtain this book to support their work in trying to bring the new directions out into reality. @source:Pharmaceutical Development & Technology