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Mechanosensitive Ion Channels, Part B - 1st Edition - ISBN: 9780121533595, 9780080494401

Mechanosensitive Ion Channels, Part B, Volume 59

1st Edition

Serial Editors: Sidney Simon Dale Benos
Serial Volume Editor: Owen Hamill
Hardcover ISBN: 9780121533595
eBook ISBN: 9780080494401
Imprint: Academic Press
Published Date: 19th April 2007
Page Count: 616
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Table of Contents

    <li>Foreword</li> <li>Previous Volumes in Series</li> <li>Chapter 1: Mechanosensitive Ion Channels of Spiders: Mechanical Coupling, Electrophysiology, and Synaptic Modulation<ul><li>Publisher Summary</li><li>I OVERVIEW</li><li>II INTRODUCTION</li><li>III TYPES OF SPIDER MECHANORECEPTORS</li><li>IV MECHANICAL COUPLING</li><li>V MECHANOTRANSDUCTION IN SLIT SENSILLA</li><li>VI DYNAMIC PROPERTIES OF MECHANOTRANSDUCTION AND ACTION POTENTIAL ENCODING</li><li>VII CALCIUM SIGNALING DURING TRANSDUCTION BY SPIDER MECHANORECEPTORS</li><li>VIII SYNAPTIC MODULATION OF SPIDER MECHANORECEPTORS</li><li>IX CONCLUSIONS</li><li>Acknowledgments</li></ul></li> <li>Chapter 2: Ion Channels for Mechanotransduction in the Crayfish Stretch Receptor<ul><li>Publisher Summary</li><li>I OVERVIEW</li><li>II INTRODUCTION</li><li>III MORPHOLOGY OF THE SRO</li><li>IV FUNCTIONAL PROPERTIES</li><li>V SUMMARY AND DISCUSSION OF FUTURE RESEARCH DIRECTIONS</li><li>Acknowledgments</li></ul></li> <li>Chapter 3: Mechanosensitive Ion Channels in Caenorhabditis elegans<ul><li>Publisher Summary</li><li>I OVERVIEW</li><li>II INTRODUCTION</li><li>III C. ELEGANS MECHANOSENSITIVE BEHAVIORS</li><li>IV C. ELEGANS DEG/ENaCs</li><li>V C. ELEGANS TRP ION CHANNELS</li><li>VI CONCLUDING REMARKS</li></ul></li> <li>Chapter 4: Properties and Mechanism of the Mechanosensitive Ion Channel Inhibitor GsMTx4, a Therapeutic Peptide Derived from Tarantula Venom<ul><li>Publisher Summary</li><li>I OVERVIEW</li><li>II INTRODUCTION</li><li>III PROPERTIES AND SPECIFICITY OF GsMTx4</li><li>IV CELLULAR SITES FOR GsMTx4</li><li>V POTENTIAL THERAPEUTIC USES FOR GsMTx4</li><li>VI CONCLUSIONS</li></ul></li> <li>Chapter 5: Mechanosensitive Channels in Neurite Outgrowth<ul><li>Publisher Summary</li><li>I OVERVIEW</li><li>II INTRODUCTION</li><li>III ENCODING OF GUIDANCE CUES IN AXON PATHFINDING</li><li>IV REQUIREMENT OF TRP CHANNELS IN CALCIUM-DEPENDENT AXON PATHFINDING</li><li>V PHYSICAL GUIDANCE CUES AND ROLE OF MECHANOSENSITIVE ION CHANNELS</li><li>VI ION CHANNELS AS MOLECULAR INTEGRATORS</li><li>VII CONCLUDING REMARKS</li><li>NOTE ADDED IN PROOF</li><li>Acknowledgments</li></ul></li> <li>Chapter 6: ENaC Proteins in Vascular Smooth Muscle Mechanotransduction<ul><li>Publisher Summary</li><li>I OVERVIEW</li><li>II INTRODUCTION</li><li>III DEG/ENaC/ASIC PROTEINS ARE MEMBERS OF A DIVERSE PROTEIN FAMILY INVOLVED IN MECHANOTRANSDUCTION</li><li>IV INVOLVEMENT OF ENaC PROTEINS IN VASCULAR SMOOTH MUSCLE MECHANOTRANSDUCTION</li><li>V SUMMARY AND FUTURE DIRECTIONS</li></ul></li> <li>Chapter 7: Regulation of the Mechano-Gated K<sub>2P</sub> Channel TREK-1 by Membrane Phospholipids<ul><li>Publisher Summary</li><li>I OVERVIEW</li><li>II INTRODUCTION</li><li>III TREK-1 STIMULATION BY MEMBRANE PHOSPHOLIPIDS</li><li>IV TREK-1 INHIBITION BY MEMBRANE PHOSPHOLIPIDS</li><li>Acknowledgments</li></ul></li> <li>Chapter 8: MechanoTRPs and TRPA1<ul><li>Publisher Summary</li><li>I OVERVIEW</li><li>II MECHANOTRP CHANNELS</li><li>III CHARACTERISTICS OF TRPA1 GENE AND PROTEIN</li><li>IV TRPA1 EXPRESSION IN MECHANOSENSORY ORGANS</li><li>V FUNCTION OF TRPA1</li><li>VI Proposed Biological Roles for TRPA1</li></ul></li> <li>Chapter 9: TRPCs as MS Channels<ul><li>Publisher Summary</li><li>I OVERVIEW</li><li>II INTRODUCTION</li><li>III PRACTICAL ASPECTS OF RECORDING MS CHANNELS</li><li>IV DISTINGUISHING DIRECT VS INDIRECT MS CHANNELS</li><li>V EXTRINSIC REGULATION OF STRETCH SENSITIVITY</li><li>VI STRATEGIES TO IDENTIFY MS CHANNEL PROTEINS</li><li>VII GENERAL PROPERTIES OF TRPCs</li><li>VIII EVIDENCE FOR TRPC MECHANOSENSITIVITY</li><li>IX CONCLUSIONS</li><li>Acknowledgments</li></ul></li> <li>Chapter 10: The Cytoskeletal Connection to Ion Channels as a Potential Mechanosensory Mechanism: Lessons from Polycystin-2 (TRPP2)<ul><li>Publisher Summary</li><li>I OVERVIEW</li><li>II INTRODUCTION</li><li>III ROLE OF ACTIN CYTOSKELETAL DYNAMICS IN PC2-MEDIATED CHANNEL FUNCTION</li><li>IV IDENTIFICATION OF ACTIN-BINDING PROTEIN INTERACTIONS WITH POLYCYSTIN-2</li><li>V EFFECT OF HYDROOSMOTIC PRESSURE ON PC2 CHANNEL FUNCTION: ROLE OF THE CYTOSKELETON IN OSMOSENSORY FUNCTION</li><li>VI THE CHANNEL&#x2013;CYTOSKELETON INTERFACE: STRUCTURAL&#x2013;FUNCTIONAL CORRELATES</li><li>VII PERSPECTIVE AND FUTURE DIRECTIONS</li></ul></li> <li>Chapter 11: Lipid Stress at Play: Mechanosensitivity of Voltage-Gated Channels<ul><li>Publisher Summary</li><li>I OVERVIEW</li><li>II THE SYSTEM COMPONENTS</li><li>III BIG PICTURE ISSUES</li><li>IV REVERSIBLE STRETCH-INDUCED CHANGES IN PARTICULAR VGCs</li><li>V IRREVERSIBLE STRETCH-INDUCED GATING CHANGES IN VGCs</li><li>VI TECHNICAL ISSUES</li><li>VII SUMMARY COMMENTS</li><li>Acknowledgments</li></ul></li> <li>Chapter 12: Hair Cell Mechanotransduction: The Dynamic Interplay Between Structure and Function<ul><li>Publisher Summary</li><li>I OVERVIEW</li><li>II AUDITORY SYSTEM</li><li>III HAIR BUNDLE STRUCTURE</li><li>IV MET INVOLVES MECHANICALLY GATED CHANNELS</li><li>V WHERE ARE THESE CHANNELS?</li><li>VI THE GATING SPRING THEORY</li><li>VII HOW ARE THE CHANNELS ACTIVATED?</li><li>VIII TO BE OR NOT TO BE TETHERED</li><li>IX CHARACTERIZING CHANNEL PROPERTIES?</li><li>X MET CHANNEL PORE</li><li>XI ADAPTATION</li><li>XII THE DYNAMIC HAIR BUNDLE</li><li>XIII SUMMARY AND FUTURE DIRECTIONS</li><li>Acknowledgments</li></ul></li> <li>Chapter 13: Insights into the Pore of the Hair Cell Transducer Channel from Experiments with Permeant Blockers<ul><li>Publisher Summary</li><li>I OVERVIEW</li><li>II INTRODUCTION</li><li>III IONIC SELECTIVITY OF THE TRANSDUCER CHANNEL</li><li>IV PERMEATION AND BLOCK OF MECHANORECEPTOR CHANNELS BY FM1-43</li><li>V PERMEATION AND BLOCK OF THE HAIR CELL TRANSDUCER CHANNEL BY AMINOGLYCOSIDE ANTIBIOTICS</li><li>VI TRANSDUCER CHANNEL BLOCK BY AMILORIDE AND ITS DERIVATIVES</li><li>VII CONCLUSIONS</li><li>Acknowledgments</li></ul></li> <li>Chapter 14: Models of Hair Cell Mechanotransduction<ul><li>Publisher Summary</li><li>I OVERVIEW</li><li>II INTRODUCTION</li><li>III TRANSDUCTION CHANNEL PROPERTIES</li><li>IV GATING</li><li>V ACTIVE HAIR BUNDLE MOTILITY</li><li>VI CONCLUSIONS</li></ul></li> <li>Chapter 15: Touch<ul><li>Publisher Summary</li><li>I OVERVIEW</li><li>II INTRODUCTION</li><li>III STRUCTURE OF SKIN AND TOUCH RECEPTORS</li><li>IV PHYSIOLOGY OF MECHANORECEPTIVE NERVE FIBERS</li><li>V QUANTITATING MECHANICAL RESPONSES IN ANIMAL MODELS</li><li>VI ELECTROPHYSIOLOGICAL APPROACHES TO MECHANOSENSATION IN RODENTS</li><li>VII MECHANOSENSITIVE ION CHANNELS IN CULTURED SENSORY NEURONS</li><li>VIII GATING MS ION CHANNELS IN DRG NEURONS</li><li>IX CANDIDATE ION CHANNELS</li><li>X VOLTAGE-GATED CHANNELS AND MECHANOSENSATION</li><li>XI INDIRECT SIGNALING BETWEEN SENSORY NEURONS AND NONNEURONAL CELLS</li><li>XII CONCLUSIONS</li><li>Acknowledgments</li></ul></li> <li>Chapter 16: Mechanosensitive Ion Channels in Dystrophic Muscle<ul><li>Publisher Summary</li><li>I OVERVIEW</li><li>II INTRODUCTION</li><li>III MS CHANNEL EXPRESSION DURING MYOGENESIS</li><li>IV PERMEABILTY PROPERTIES OF MS CHANNELS IN SKELETAL MUSCLE</li><li>V GATING</li><li>VI PHARMACOLOGY</li><li>VII CONCLUSIONS</li></ul></li> <li>Chapter 17: MscCa Regulation of Tumor Cell Migration and Metastasis<ul><li>Publisher Summary</li><li>I OVERVIEW</li><li>II INTRODUCTION</li><li>III DIFFERENT MODES OF MIGRATION</li><li>IV Ca<sup>2+</sup> DEPENDENCE OF CELL MIGRATION</li><li>V THE ROLE OF MscCa IN CELL MIGRATION</li><li>VI CAN EXTRINSIC MECHANICAL FORCES ACTING ON MscCa SWITCH ON CELL MIGRATION?</li><li>Acknowledgments</li></ul></li> <li>Chapter 18: Stretch-Activated Conductances in Smooth Muscles<ul><li>Publisher Summary</li><li>I OVERVIEW</li><li>II INTRODUCTION</li><li>III MECHANOSENSITIVE CONDUCTANCES THAT GENERATE INWARD CURRENTS</li><li>IV MECHANOSENSITIVE CONDUCTANCES THAT GENERATE OUTWARD CURRENTS</li></ul></li> <li>Chapter 19: Mechanosensitive Ion Channels in Blood Pressure-Sensing Baroreceptor Neurons<ul><li>Publisher Summary</li><li>I OVERVIEW</li><li>II INTRODUCTION</li><li>III BR SENSORY TRANSDUCTION</li><li>IV MECHANOSENSITIVE CHANNELS IN BR NEURONS</li><li>V METHODOLOGICAL LIMITATIONS AND CHALLENGES</li><li>VI SUMMARY AND FUTURE DIRECTIONS</li><li>Acknowledgments</li></ul></li> <li>Index</li>


Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include ENaC Proteins in Vascular Smooth Muscle Mechanotransduction; Regulation of the Mechano-Gated K2P Channel TREK-1 by Membrane Phospholipids; MechanoTRPs and TRPA1; TRPC; The Cytoskeletal Connection to Ion Channels as a Potential Mechanosensory Mechanism. Lessons From Polycystin-2 (TRPP2); Lipid Stress at Play: Mechanosensitivity of Voltage-Gated Channels; Hair Cell Mechanotransduction: The Dynamic Interplay between Structure and Function; Pharmacology of Hair Cell MS Channels; Hair Cell Mechanotransduction; Models of Hair Cell Mechanotrasduction; Touch; Mechanosensitive Ion Channels in Dystrophic Muscle; Mechanotransduction in Endothelial Cells; MS Channels in Tumor Cell Migration; Mechanosensitive Channels in Regulating Smooth Muscle Contraction in the GI; Mechanosensitive Ion Channels in Blood-Pressure-Sensing Baroreceptor Neurons.


Researchers in cell biology, developmental biology, biochemistry, bioengineering, genetics, immunology, immunochemistry, neuroscience, diabetes, nephrology, embyrology, vascular surgery, cardiology, rheumatology, hematology, bone and joint surgery, cancer research, and angiogenesis.


No. of pages:
© Academic Press 2007
19th April 2007
Academic Press
Hardcover ISBN:
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Ratings and Reviews

About the Serial Editors

Sidney Simon

Affiliations and Expertise

Department of Neurobiology, Duke University Medical Center, Durham, NC, USA

Dale Benos

Affiliations and Expertise

Department of Physiology and Biophysics, University of Alabama, Birmingham, USA

About the Serial Volume Editor

Owen Hamill