Mechanobiology

Mechanobiology: From Molecular Sensing to Disease will provide a review of the current state of understanding of mechanobiology and its role in health and disease. It covers: Current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli, A review of diseases that with known or purported mechanobiological underpinnings; The role of mechanobiology in tissue engineering and regenerative medicine; Experimental methods to capture mechanobiological phenomena; Computational models in mechanobiology.

• Presents our current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli
• Provides a review of diseases with known or purported mechanobiological underpinnings
• Includes the role of mechanobiology in tissue engineering and regenerative medicine
• Covers experimental methods to capture mechanobiological phenomena

Research, post-doctoral scholars, graduate students, Medical device and regenerative medicine designers and manufacturers

Section 1: Mechanobiological basis of diseases
1.1 Osteoporosis
1.2 Cardiovascular mechanics and disease
1.3 Glaucoma and eye diseases
1.4 Growth and development
1.5 Tissue engineering and regenerative medicine

Section 2: Cellular basis of Mechanobiology
2.1 Cells as strain gages and load cells
2.2 Cell – extracellular matrix interactions
2.3 Mechanobiological pathways
2.4 Mechanically mediated epigenetics

Section 3: Experimental methods
3.1 Effects of shear stress on cells
3.2 Three-dimensional culture systems
3.3 Bioreactors
3.4 Tissue and organ on a chip systems

Section 4: Computational simulations in mechanobiology
4.1 Cell aggregation
4.2 Growth models
5. Future prospects and challenges
6. Bibliography
7. Glossary