Description

Written by research experts, this volume of Progress in Molecular Biology and Translational Science focuses on current science surrounding the mechanisms of DNA repair.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field

Readership

Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.

Table of Contents

Contributors

Preface

Chapter 1 Dynamics of Lesion Processing by Bacterial Nucleotide Excision Repair Proteins

I. Structural Insights of Bacterial Nucleotide Excision Repair

II. So Few DNA Repair Proteins, So Much DNA: Defining the Big Problem

III. Damage Searching by UvrA2 and UvrA2B2

IV. Future Directions

Chapter 2 Transcription-Coupled DNA Repair in Prokaryotes

I. Introduction

II. Background: Genomic Heterogeneity in NER and the Discovery of TCR

III. The Role of RNA Polymerase in TCR

IV. The Role of Mfd in TCR

V. The Role of UvrA in TCR

VI. The Role of UvrB in TCR

VII. Other Examples of Transcription-Related DNA Damage Processing in Bacteria

VIII. Conclusions

Chapter 3 The Functions of MutL in Mismatch Repair

I. Overview of DNA Mismatch Repair

II. MutL is a Multidomain Protein

III. Architecture of the Endonuclease Domain

IV. Regulation of the Endonuclease Activity of MutL

V. Concluding Remarks

Chapter 4 The Fpg/Nei Family of DNA Glycosylases

I. Introduction

II. Fpg/Nei Phylogeny

III. Fpg/Nei Structures

IV. Glycosylases Search for Lesions

V. Concluding Remarks

Chapter 5 Regulation of Base Excision Repair in Eukaryotes by Dynamic Localization Strategies

I. Base Excision Repair

II. Dynamic Localization of BER Proteins

III. Hypotheses on the Orchestration of Dynamic Localization

Chapter 6 Oxidized Base Damage and Single-Strand Break Repair in Mammalian Genomes

I. Oxidative DNA Damage and Its Repair in Mammalian Cells

II. Complexity and Sub-pathways of BER/SSBR

III. Nonconserved Terminal Extensions in Mammalian Early BER Proteins

IV. Posttranslational Modifications in Early BER Proteins

V. BER/SSBR Deficiency in Human Diseases

VI. Conc

Details

No. of pages:
336
Language:
English
Copyright:
© 2012
Published:
Imprint:
Academic Press
eBook ISBN:
9780123876669
Print ISBN:
9780123876652

About the serial-volume-editor

Reviews

Praise for the series:
"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal