Mechanisms of DNA Repair

Mechanisms of DNA Repair

1st Edition - July 17, 2012

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  • Editor: Paul Doetsch
  • eBook ISBN: 9780123876669
  • Hardcover ISBN: 9780123876652

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Written by research experts, this volume of Progress in Molecular Biology and Translational Science focuses on current science surrounding the mechanisms of DNA repair.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.

Table of Contents

  • Contributors


    Chapter 1 Dynamics of Lesion Processing by Bacterial Nucleotide Excision Repair Proteins

    I. Structural Insights of Bacterial Nucleotide Excision Repair

    II. So Few DNA Repair Proteins, So Much DNA: Defining the Big Problem

    III. Damage Searching by UvrA2 and UvrA2B2

    IV. Future Directions

    Chapter 2 Transcription-Coupled DNA Repair in Prokaryotes

    I. Introduction

    II. Background: Genomic Heterogeneity in NER and the Discovery of TCR

    III. The Role of RNA Polymerase in TCR

    IV. The Role of Mfd in TCR

    V. The Role of UvrA in TCR

    VI. The Role of UvrB in TCR

    VII. Other Examples of Transcription-Related DNA Damage Processing in Bacteria

    VIII. Conclusions

    Chapter 3 The Functions of MutL in Mismatch Repair

    I. Overview of DNA Mismatch Repair

    II. MutL is a Multidomain Protein

    III. Architecture of the Endonuclease Domain

    IV. Regulation of the Endonuclease Activity of MutL

    V. Concluding Remarks

    Chapter 4 The Fpg/Nei Family of DNA Glycosylases

    I. Introduction

    II. Fpg/Nei Phylogeny

    III. Fpg/Nei Structures

    IV. Glycosylases Search for Lesions

    V. Concluding Remarks

    Chapter 5 Regulation of Base Excision Repair in Eukaryotes by Dynamic Localization Strategies

    I. Base Excision Repair

    II. Dynamic Localization of BER Proteins

    III. Hypotheses on the Orchestration of Dynamic Localization

    Chapter 6 Oxidized Base Damage and Single-Strand Break Repair in Mammalian Genomes

    I. Oxidative DNA Damage and Its Repair in Mammalian Cells

    II. Complexity and Sub-pathways of BER/SSBR

    III. Nonconserved Terminal Extensions in Mammalian Early BER Proteins

    IV. Posttranslational Modifications in Early BER Proteins

    V. BER/SSBR Deficiency in Human Diseases

    VI. Conclusions and Future Perspectives

    Chapter 7 Homologous Recombination in Eukaryotes

    I. Meiosis

    II. DSB Repair in Somatic Cells

    III. RAD52 Epistasis Group

    IV. Recombination Mediators

    V. RAD51 Paralogs

    VI. DSB Repair in Chromatin

    VII. Postsynaptic Removal of RAD51

    VIII. Second-End Capture

    IX. dHJ Dissolution

    X. Holliday Junction Resolution

    XI. Homeologous Recombination: The Interplay Between Mismatch Repair and HR

    XII. Conclusion

    Chapter 8 Overview for the Histone Codes for DNA Repair

    I. Histone Modifications of Homologous Recombination Repair

    II. Histone Modifications of NHEJ

    III. Histone Modifications of Nucleotide Excision Repair

    IV. Histone Modifications of Base Excision Repair

    V. DNA Mismatch Repair and Histone Modifications

    Chapter 9 The RSC and INO80 Chromatin-Remodeling Complexes in DNA Double-Strand Break Repair

    I. Introduction

    II. RSC

    III. INO80

    IV. Perspectives

    Chapter 10 Mechanistic Links Between ATM and Histone Methylation Codes During DNA Repair

    I. The DNA Damage Response

    II. Ataxia telangiectasia and the ATM Kinase

    III. The Tip60 Acetyltransferase

    IV. H3K9me3 and DDR

    V. Conclusions and Implications for Cancer Therapy

    Chapter 11 Exploiting Synthetic Lethal Interactions Between DNA Damage Signaling, Checkpoint Control, and p53 for Targeted Cancer Therapy

    I. Introduction

    II. The Concept of Synthetic Lethality in Cancer Therapy

    III. Synthetic Lethality Between PARP1 and BRCA1/2 as a Model for Enhancing DNA Damage-Induced Cell Death

    IV. Synthetic Lethality in the Context of p53 Mutations

    V. Potential for Future Therapies


Product details

  • No. of pages: 336
  • Language: English
  • Copyright: © Academic Press 2012
  • Published: July 17, 2012
  • Imprint: Academic Press
  • eBook ISBN: 9780123876669
  • Hardcover ISBN: 9780123876652

About the Serial Volume Editor

Paul Doetsch

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