Mechanisms of Disease Pathogenesis in Multiple Sclerosis

Mechanisms of Disease Pathogenesis in Multiple Sclerosis

1st Edition - December 1, 2022

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  • Editor: Francisco Quintana
  • Paperback ISBN: 9780128238486

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Description

Mechanisms of Disease Pathogenesis in Multiple Sclerosis summarizes our current understanding on MS and its clinical features and monitoring with available biomarkers, focusing on mechanisms that drive disease pathogenesis and their control by genetic, environmental factors and novel therapies for disease management. The book is written for neurologists, neuroimmunologists and clinical, translational and basic researchers interested in mechanisms of neurodegeneration. Multiple Sclerosis (MS) is an autoimmune disease which targets the central nervous system (CNS). It is the most common cause of non-traumatic neurological disability in young adults with a prevalence of 1 in 1000 and increasing, hence the importance of this book.  

Key Features

  • Summarizes our current understanding of Multiple Sclerosis
  • Discusses clinical features and available biomarker monitoring
  • Focuses on mechanisms that drive disease pathogenesis

Readership

Neurologists, neuroimmunologists and clinical, translational and basic researchers interested in mechanisms of neurodegeneration

Table of Contents

  • 1. Multiple Sclerosis. Clinical course, open questions, unmet clinical needs
    2. CNS Imaging in Multiple Sclerosis
    3. Biomarkers in Multiple Sclerosis
    4. Pre-clinical Models of Multiple Sclerosis
    5. iPSC Models to Study Multiple Sclerosis
    6. T cells in Multiple Sclerosis
    7. B cells in Multiple Sclerosis
    8. Antibodies in Multiple Sclerosis
    9. Microglia in Multiple Sclerosis
    10. Peripheral myeloid cells in Multiple Sclerosis
    11. Antigen Presenting Cells in Multiple Sclerosis
    12. Oligodendrocytes in Multiple Sclerosis
    13. Astrocytes in Multiple Sclerosis
    14. The Blood Brain Barrier in Multiple Sclerosis
    15. Brain Lymphatics in Multiple Sclerosis
    16. Mechanisms of Neurodegeneration in Multiple Sclerosis
    17. Microbiome in Multiple Sclerosis
    18. Genetics of Multiple Sclerosis
    19. Environmental Factors in Multiple Sclerosis
    20. Novel Therapies for Multiple Sclerosis

Product details

  • No. of pages: 500
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: December 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780128238486

About the Editor

Francisco Quintana

Francisco J. Quintana, PhD, is an Associate Professor of Neurology at the Center for Neurologic Diseases, at Brigham and Women’s Hospital, Harvard Medical School, and an Associate Member at the Broad Institute of Harvard and MIT. Dr. Quintana’s research investigates signaling pathways that control the immune response and neurodegeneration, with the ultimate goal of identifying novel therapeutic targets and biomarkers for immune-mediated disorders. Dr. Quintana has published over 140 peer reviewed articles and book chapters. He is the recipient of the Lady Anne Chain Prize for Academic Excellence and Scientific Achievements, the Junior Investigator Award from the National Multiple Sclerosis Society, the Pathway to Independence Award of the National Institute of Allergy and Infectious Diseases, the Award for Outstanding Research Achievement form Nature Biotechnology and the Tecan Award for Innovation, the Harry Weaver Award from the National Multiple Sclerosis Society, the Young Mentor Award from Harvard Medical School and the Milestones in MS research from the National MS Society.

Affiliations and Expertise

Associate Scientist, Brigham and Women's Hospital; Professor of Neurology, Harvard Medical School; Brigham and Women's Hospital

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