Mechanisms of Cytotoxicity by NK Cells - 1st Edition - ISBN: 9780123413703, 9780323143356

Mechanisms of Cytotoxicity by NK Cells

1st Edition

Editors: Ronald Herberman
eBook ISBN: 9780323143356
Imprint: Academic Press
Published Date: 28th January 1985
Page Count: 694
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Mechanisms of Cytotoxicity by NK Cells is the resulting book of a workshop focused on the studies that enhance understanding of the basic mechanisms involved in the function and regulation of NK cells. The book presents the status of knowledge of the mechanisms responsible for the cytotoxic effects of NK cells and the regulation of their activity.
The text is further divided into five major sections according to the sequence of the workshop sessions. A separate chapter from the sections has been included at the beginning of the book. The introductory chapter clarifies some points in the subject area of NK cells, particularly its definition. The heterogeneity of NK cells is also discussed in this chapter. Then, the book presents the major topics, including the purification and characterization of NK cells and NK target structures and recognition sites. The mechanisms of postrecognition interactions between NK cells and targets; regulation of NK activity and NK cells; and cultured cells with NK-like activity are also discussed.
This book will serve as a helpful guide to students and professionals (scientists, researchers, and professors) in the fields of immunology, biology, microbiology, biochemistry, among others.

Table of Contents



I Purification and Characterization of NK Cells

Purification and Characterization of NK Cells

Surface Phenotype and Functions of Human Natural Killer Cells

Characteristics of Mouse NK Cells and Their Precursors

Enrichment Methodology for Murine NK Activity

II Characterization of NK Target Structures and Recognition Sites on NK Cells

Molecular Characterization of NK Target Antigens and Target Recognition Sites on NK Cells

Analysis of NK Target Structures. K562 Membrane Components Associated with Susceptibility to NK Attack

Role of Target Histocompatibility Antigens in Regulation of Natural Killer Activity: A Reevaluation and a Hypothesis

Role of NK Cells in Hybrid Resistance to Bone Marrow Grafts

Evidence That Natural Killer Cells Are Pre-Thymic T Cells with Receptors for Self and Non-Self H Antigens

Receptors for "Self" Recognition Shared by Human T Lymphocytes and NK Cells

Analysis of NK Activity against Virus-Infected Target Cells

III Mechanisms of Postrecognition Interactions between NK Cells and Targets

Biochemistry of NK Cytotoxicity

NK-Target Cell Interactions in Binding, Triggering, Programming, and Lethal Hit Stages of NK Cytotoxicity

NK Mediated Cell Lysis: A Directed Secretory Event of Cytolytic Tubular Structures

Involvement of the Cytoskeleton and an Associated 95 KD Protein in Recognition and Lysis by NK Cells

Ultrastructural Analysis of Human Natural Killer Cell-Target Cell Interactions Leading to Target Cell Lysis

Role of Proteases in NK Activity

Enzymes Involved in Natural Killer Cell Activity: Evidence for Phospholipases, Lipoxygensases, and Serine Dependent Proteinases

The Role of Phospholipid Methylation and Chromosomally Regulated Target Structures in Pre- and Post-Recognition Events in the NK Cytolytic Pathway

Monosaccharide Concentration Dependent Inhibition of Human Natural Cytotoxicity

The Potential Role of Arachidonic Acid Metabolism in Human Natural Killer Cell Activity

The Role of the Lipoxygenase in Regulation of NK Activity

No Confirmed Role for Reactive Oxygen Intermediates in Natural Killer (NK) Cell-Mediated Cytolysis

Oxidative Burst Does Not Mediate Human Monocyte Tumoricidal Activity

The Role of Cytoplasmic Granules in NK Cell Cytotoxicity

Functional and Biochemical Characterization of Natural Killer Cytotoxic Factors and Their Role in the NK Lytic Mechanism

Characteristics of Human Natural Killer Cytotoxic Factor (NKCF) Lysis and Possible Relationship to Lysis by NK Cells

Role of Soluble Lytic Factors in NK Activity

Cytotoxic Factors from Marmoset Monkey NK-Like Cell Lines

IV Regulation of NK Activity and Regulation by NK Cells

Regulation of NK Cells

Kinetic Models for Natural Cytotoxicity and Their Use for Studying Activated NK Cells

Augmentation of Natural Killer Cell Activity by Recombinant Interleukin-2 and Recombinant Interferons

Lymphokines Involved in the Generation and Regulation of NK and NC Cells

Regulation of Mouse NK Activity

Alterations in Numbers of LGLs as Important Component of Regulation of NK Activity

Effects of Phorbol Esters on NK Activity

Characterization of Soluble Suppressor Factors Produced by Unstimulated Normal Human Lymphocytes

Role of Transferrin and Transferrin-Related Proteins in Regulation of NK Activity in Vitro

Effect of UVR and Membrane Fluidity on NK Cytotoxic Activity

Immunoregulatory Effects of NK Cells

Regulation of the B Cell Response by NK Cells

Defective NK Cell Mechanism in Patients with Leukemia

Characterization of NK Cells in Patients with Chronic Myelogenous Leukemia

Natural Killer Cell Activity in Genetic Diseases

V Cultured Cells with NK-Like Activity: Models for Analysis of NK Activity

NK Clones: Isolation and Characterizations

K562 Tumor Cells Preferentially Activate Leu 11 + Human Large Granular Lymphocytes in a Mixed Lymphocyte Response Culture

Discrimination between Anomolous Killer Cells and NK-Like Cells

Differentiation of Large Granular Lymphocytes during Induction of Activated Killer Cells in Vitro

Patterns of Proliferation in Human NK Cells: Practical and Theoretical Implications

Culture of NK Cells: Specificity, Phenotypes, Functions, and Comparison with Activated T Cells

Analysis and Functional Characterization of T3-, NK Cell Derived and T3+, CTL Precursor Cell Derived Clones

NK Cells and T Cell Differentiation

Recognitive Heterogeneity of NK Cells



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© Academic Press 1985
Academic Press
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About the Editor

Ronald Herberman

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