Mechanisms of Chemical Carcinogenesis

Mechanisms of Chemical Carcinogenesis

1st Edition - February 4, 1986

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  • Author: D. E. Hathway
  • eBook ISBN: 9781483192468

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Mechanisms of Chemical Carcinogenesis provides information pertinent to the fundamental mechanisms of chemical carcinogenesis. This book surveys the interactions of chemical carcinogens with native DNA, the activation of normal cellular sequences, and the transforming role of the activated genes. Organized into seven chapters, this book begins with an overview of the relationship between the incidence of lung cancer and the frequency and duration of cigarette smoking. This text then examines the concept that carcinogens may require metabolic activation before they initiate carcinogenesis. Other chapters consider the structure of the nucleoside adducts resulting from the hydrolysis of salmon-sperm DNA and rat-liver ribosomal RNA. This book discusses as well the persistence of nucleoside analogues in target-tissue nucleic acid. The final chapter deals with mutational theory. This book is a valuable resource for workers involved with cancer research, toxicology, and molecular biology. Specialists in drug development, industrial hygiene and occupational medicine will also find this book useful.

Table of Contents

  • 1 Introduction

    Landmarks in the Recognition of Chemical Carcinogenesis

    Developing Theory from Its Roots in Experiment

    Bibliography and References

    2 Activation of Chemical Carcinogens in the Mammal

    Presumptive Evidence of Metabolic Activation

    Reactive Metabolites of Chemical Carcinogens

    Biosynthesis of Reactive Metabolites and Matching Tissue Specificities

    Bibliography and References

    3 Authenticated Interactions with Nucleic Acid

    Aromatic Amines and Amino-Azo Dyes

    Nitrosamines and 3-Alkyl-1-Phenyltriazines


    Vinyl Chloride



    Polycyclic Aromatic Hydrocarbons


    Concluding Remarks

    Bibliography and References

    4 Mechanisms in Perspective: Biological Significance of Modified Deoxyribonucleoside Residues in DNA

    Repair of Biochemical Lesions in DNA

    Miscoding Induced by Carcinogens during Directed Nucleic Acid Biosynthesis

    Effects On the Biosynthesis of Inter-Related Macromolecules

    Bibliography and References

    5 Mechanisms in Perspective: Inhibition of Tumor Induction

    Inhibition of Tumor Initiation by Metabolic Inducers and Inhibitors

    Inhibition of Tumor Initiation by the Interaction of Nucleophiles with Reactive Carcinogen Intermediates

    Inhibition of Tumor Initiation through the Induction of DNA-Repair Mechanisms

    Bibliography and References

    6 Mechanisms in Perspective: Tumor Promotion

    Two-Stage Carcinogenesis in the Skin System

    The Croton Oil Promoters

    Tumor Promoters for Other Physiological Systems

    Other Experimental Models of Two-Stage Carcinogenesis

    Mode of Action of Tumor Promotion in the Skin

    Bibliography and References

    7 Standard Mutational Theory of Cancer and the Impact of Contingent Advances in Genetics

    Somatic Cell Mutation

    Cancer Models

    The 'Oncogene'/Proto-Oncogene Concept

    The Developing 'Oncogene' Story

    Activation of Oncogenes'

    Proteins Encoded by Activated 'Oncogenes'

    Concluding Remarks

    Bibliography and References


Product details

  • No. of pages: 144
  • Language: English
  • Copyright: © Butterworth-Heinemann 1986
  • Published: February 4, 1986
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483192468

About the Author

D. E. Hathway

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