Contents. List of Contributors. Introduction to Cell Toxicity: a Perspective on Intracellular Targets (J.K. Chipman). The Role of Xenobiotic Metabolism in Cell Toxicity (S. Vamvakas). Reactive Oxygen Species and their Cytotoxic Mechanisms (M.D. Evans, H.R. Griffiths, and J. Lunec). Calcium, Glutathione, and the Role of Mitochondria in Cell Injury and Death (D.J. Reed). The Cytoskeleton as a Target in Cell Toxicity (A.J. Hargreaves). Cell Death Via Interactions of Agents with DNA (J.A. Holme, R. Wiger, J.K. Honslo, E.J. Soderlund, G. Brunborg, and E. Dybing). Mechanisms of Apoptoss (A.C. Bayly, R.A. Roberts, and C. Dive). Index.