Mechanisms of Cell Death and Opportunities for Therapeutic Development

Mechanisms of Cell Death and Opportunities for Therapeutic Development

1st Edition - August 1, 2019

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  • Editor: Diaqing Liao
  • eBook ISBN: 9780128142097
  • Paperback ISBN: 9780128142080

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Description

Mechanisms of Cell Death and Opportunities for Therapeutic Development, volume four in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. The book covers fundamental mechanisms, ranging from different forms of cell death and drug development, to efforts for treating disease, providing a valuable resource for readers interested in understanding cell death and relevant translational research. The book's editor, Diaqing Liao, has over twenty years’ experience teaching topics of cell death.

Key Features

  • Provides a comprehensive overview of current knowledge on the process of apoptosis, its potential role in health and disease, and a discussion of potential alternative forms, such as autophagy
  • Covers fundamental mechanisms and relevant translational research

Readership

In the fields of biomedical research and drug discovery and development including graduate students, postdocs and faculty in academia and scientists in research and development in biotech and pharmaceutical industry

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • List of contributors
  • Chapter 1. Apoptosis, necroptosis, and pyroptosis in health and disease: an overview of molecular mechanisms, targets for therapeutic development, and known small molecule and biologic modulators
  • 1. Introduction
  • 2. The apoptotic pathways and major targets for drug development
  • 3. Necroptosis: mechanism, disease implications, and potential therapeutics
  • 4. Pyroptosis
  • 5. Concluding remarks
  • Chapter 2. Cell death: machinery and regulation
  • 1. Introduction
  • 2. Nonapoptotic cell death
  • 3. Apoptotic cell death
  • 4. Conclusions and perspectives
  • Chapter 3. Molecular mechanisms of cell death: a brief overview
  • 1. Introduction
  • 2. Intrinsic apoptotic pathway
  • 3. Extrinsic apoptotic pathway
  • 4. Caspases
  • 5. The inhibitors of apoptosis
  • 6. Other types of programmed cell death
  • 7. Conclusion
  • Chapter 4. Major methods and technologies for assessing cell death
  • 1. Introduction
  • 2. Morphological changes during cell death
  • 3. Assays for apoptosis
  • 4. Assays for necrosis
  • 5. Assays for autophagy
  • 6. Novel genetically encoded reporters of apoptosis
  • Chapter 5. Proteotoxicity and endoplasmic reticulum stress-mediated cell death
  • 1. Introduction to proteotoxicity and UPR pathways
  • 2. ER stress pathways and cell death regulation
  • 3. ER calcium regulation and ER stress-mediated cell death
  • 4. ER stress-related diseases
  • 5. Disease intervention for ER stress-related disorders
  • Chapter 6. Protein phase separation in cell death and survival
  • 1. Phase separation
  • 2. Cell death pathways
  • 3. Cell survival: cancer and the avoidance of cell death
  • 4. Conclusion
  • Chapter 7. Therapeutics targeting BCL2 family proteins
  • 1. Apoptotic pathways
  • 2. Structure and function of BCL2 family proteins
  • 3. BCL2 family proteins and diseases
  • 4. Therapeutics targeting the BCL2 family
  • 5. Perspective
  • Chapter 8. Ferroptosis: lipids, iron, cellular defense mechanisms and opportunities for drug development
  • 1. Introduction
  • 2. Roles of PUFAs in ferroptosis
  • 3. The requirement of labile iron in the induction ferroptosis
  • 4. Cellular defense mechanisms against ferroptosis
  • 5. Knowledge in the mechanisms of ferroptosis provides ample opportunities for developing therapeutics
  • 6. Summary and perspectives
  • Index

Product details

  • No. of pages: 296
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: August 1, 2019
  • Imprint: Academic Press
  • eBook ISBN: 9780128142097
  • Paperback ISBN: 9780128142080

About the Editor

Diaqing Liao

Diaing Liao has extensive experience, over twenty years, in research and teaching related to topics of cell death. He has been the course director of a graduate level course “Apoptosis” for over ten years at University of Florida. Dr. Liao’s research has focused on mechanisms underlying cancer biology, epigenetic regulation and drug discovery. His lab has contributed numerous original publications on cellular and viral regulators of cell death and signalling pathways.

Affiliations and Expertise

Department of Anatomy and Cell Biology, School of Medicine, University of Florida, FL, USA

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