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Mechanisms of Cell Death and Opportunities for Therapeutic Development - 1st Edition - ISBN: 9780128142080

Mechanisms of Cell Death and Opportunities for Therapeutic Development

1st Edition

Editor: Diaqing Liao
Paperback ISBN: 9780128142080
Imprint: Academic Press
Published Date: 1st November 2021
Page Count: 660
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Table of Contents

1. An overview of cell death in health and disease
2. Cell death during development
3. Molecular mechanisms of apoptosis
4. Signaling pathways in cell death
5. Genetic and epigenetic regulation of cell death
6. Major methods and technologies for assessing cell death
7. Necroptosis
8. Ferroptosis
9. Autophagic cell death
10. Proteotoxicity and endoplasmic reticulum stress-mediated cell death
11. Neuronal cell death and neurodegenerative diseases
12. Cell death in metabolic diseases
13. Pathogens, inflammasome and cell death
14. Regulation of cell death in cancer
15. Mechanisms underlying drug resistance in cancer therapy
16. Immunological cell death in cancer therapy
17. Therapeutics targeting the BCL-2 pathway
18. Novel pharmacological agents targeting the inhibitors of apoptosis (IAPs)
19. Therapeutics that potentiate p53-mediated apoptosis
20. Opportunities and challenges for drug development for activating the extrinsic apoptotic pathway in cancer
22. Therapeutic approaches to prevent excessive cell death
23. Clinical studies of cancer therapeutics targeting the cell death pathways


Mechanisms of Cell Death and Opportunities for Therapeutic Development, volume four in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. The book covers fundamental mechanisms, ranging from different forms of cell death and drug development, to efforts for treating disease, providing a valuable resource for readers interested in understanding cell death and relevant translational research. The book's editor, Diaqing Liao, has over twenty years’ experience teaching topics of cell death.

Key Features

  • Provides a comprehensive overview of current knowledge on the process of apoptosis, its potential role in health and disease, and a discussion of potential alternative forms, such as autophagy
  • Covers fundamental mechanisms and relevant translational research


In the fields of biomedical research and drug discovery and development including graduate students, postdocs and faculty in academia and scientists in research and development in biotech and pharmaceutical industry


No. of pages:
© Academic Press 2021
1st November 2021
Academic Press
Paperback ISBN:

Ratings and Reviews

About the Editor

Diaqing Liao

Diaing Liao has extensive experience, over twenty years, in research and teaching related to topics of cell death. He has been the course director of a graduate level course “Apoptosis” for over ten years at University of Florida. Dr. Liao’s research has focused on mechanisms underlying cancer biology, epigenetic regulation and drug discovery. His lab has contributed numerous original publications on cellular and viral regulators of cell death and signalling pathways.

Affiliations and Expertise

Department of Anatomy and Cell Biology, School of Medicine, University of Florida, FL, USA