Mechanisms of Cell Death and Opportunities for Therapeutic Development

1st Edition - October 26, 2021
Editor: Diaqing Liao
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 1 4 2 0 8 - 0
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 4 2 0 9 - 7

Mechanisms of Cell Death and Opportunities for Therapeutic Development, volume four in the Perspectives in Translational Cell Biology series, offers content for professors, stud… Read more

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Mechanisms of Cell Death and Opportunities for Therapeutic Development, volume four in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. The book covers fundamental mechanisms, ranging from different forms of cell death and drug development, to efforts for treating disease, providing a valuable resource for readers interested in understanding cell death and relevant translational research. The book's editor, Diaqing Liao, has over twenty years’ experience teaching topics of cell death.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Chapter 1. Apoptosis, necroptosis, and pyroptosis in health and disease: an overview of molecular mechanisms, targets for therapeutic development, and known small molecule and biologic modulators
1. Introduction
2. The apoptotic pathways and major targets for drug development
3. Necroptosis: mechanism, disease implications, and potential therapeutics
4. Pyroptosis
5. Concluding remarks
Chapter 2. Cell death: machinery and regulation
1. Introduction
2. Nonapoptotic cell death
3. Apoptotic cell death
4. Conclusions and perspectives
Chapter 3. Molecular mechanisms of cell death: a brief overview
1. Introduction
2. Intrinsic apoptotic pathway
3. Extrinsic apoptotic pathway
4. Caspases
5. The inhibitors of apoptosis
6. Other types of programmed cell death
7. Conclusion
Chapter 4. Major methods and technologies for assessing cell death
1. Introduction
2. Morphological changes during cell death
3. Assays for apoptosis
4. Assays for necrosis
5. Assays for autophagy
6. Novel genetically encoded reporters of apoptosis
Chapter 5. Proteotoxicity and endoplasmic reticulum stress-mediated cell death
1. Introduction to proteotoxicity and UPR pathways
2. ER stress pathways and cell death regulation
3. ER calcium regulation and ER stress-mediated cell death
4. ER stress-related diseases
5. Disease intervention for ER stress-related disorders
Chapter 6. Protein phase separation in cell death and survival
1. Phase separation
2. Cell death pathways
3. Cell survival: cancer and the avoidance of cell death
4. Conclusion
Chapter 7. Therapeutics targeting BCL2 family proteins
1. Apoptotic pathways
2. Structure and function of BCL2 family proteins
3. BCL2 family proteins and diseases
4. Therapeutics targeting the BCL2 family
5. Perspective
Chapter 8. Ferroptosis: lipids, iron, cellular defense mechanisms and opportunities for drug development
1. Introduction
2. Roles of PUFAs in ferroptosis
3. The requirement of labile iron in the induction ferroptosis
4. Cellular defense mechanisms against ferroptosis
5. Knowledge in the mechanisms of ferroptosis provides ample opportunities for developing therapeutics
6. Summary and perspectives
Index