Mechanisms in Bioenergetics

Mechanisms in Bioenergetics

1st Edition - January 1, 1965

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  • Author: Efraim Racker
  • eBook ISBN: 9781483268934

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Description

Advanced Biochemistry: Mechanisms in Bioenergetics provides information pertinent to the fundamental aspects of the mechanisms in bioenergetics. This book covers a variety of topics, including the enzymatic mechanism of ATP formation and the regulatory mechanisms that control its metabolic utilization. Organized into three parts encompassing 18 lectures, this book begins with an overview of the process of converting nutrients into forms of useful energy, which is the essence of energy metabolism. This text then explores the properties that have a specific bearing on the problem of oxidative phosphorylation. Other lectures consider the phosphoroclastic reaction with pyruvate, which plays a curious and apparently specific role in nitrogen fixation. This book discusses as well the operation of control mechanisms of energy metabolism in intact cells. The final lecture analyzes the rate-limiting steps in carbohydrate metabolism of various cells and some of the metabolic factors that govern them. This book is a valuable resource for graduate students.

Table of Contents


  • Preface

    Abbreviations

    Reference Abbreviations

    Part I Formation of Adenosine Triphosphate in Soluble Systems

    Lecture 1 General Considerations of Energy Production

    Substrate Level Oxidative Phosphorylation

    Phosphoroclastic Reactions

    Dehydration of 2-Phosphoglycerate Catalyzed by Enolase

    Oxidative Phosphorylation and Photophosphorylation

    Lecture 2 Substrate Level Oxidative Phosphorylation (A)

    Oxidation of Glyceraldehyde 3-Phosphate

    Lecture 3 Substrate Level Oxidative Phosphorylation (B)

    Oxidation of Glyceraldehyde 3-Phosphate

    Lecture 4 Substrate Level Oxidative Phosphorylation (C)

    Oxidation of Acetaldehyde in Bacteria

    Aspartic Semialdehyde Dehydrogenase

    Oxidation of α-Ketoglutarate and Pyruvate

    Other Variants

    Lecture 5 Phosphoroclastic Reactions: Phosphoketolase

    Phosphoketolase

    Lecture 6 Other Phosphoroclastic Reactions

    Reactions with Pyruvate

    Phosphorolysis of a C—N Bond

    Phosphorolysis of Thiol Esters

    Dehydration of 2-Phosphoglycerate Catalyzed by Enolase

    Part II Formation of Adenosine Triphosphate in Particulate Systems

    Lecture 7 Oxidative Phosphorylation in Mitochondria

    Stages of Discovery

    Mitochondrial Enzymes

    Lecture 8 The Respiratory Chain

    Cytochromes 𝒂 and 𝒂3

    Cytochrome 𝒄

    Cytochrome 𝒄1

    Cytochrome 𝒃

    Flavoproteins

    Pyridine Nucleotides

    Ubiquinone-Coenzyme 𝑄

    Phospholipids

    Structural Protein

    Electron Carriers

    Lecture 9 Localization of Phosphorylation Sites in Mitochondria

    The Crossover Point

    Measurements of the Three Phosphorylation Sites

    Thermodynamic Considerations

    Lecture 10 Exchange Reactions in Oxidative Phosphorylation

    The Pi32-ATP Exchange

    Quantitative Evaluation

    The ADP-ATP Exchange

    The H2O18-Pi and H2O18-ATP Exchanges

    Lecture 11 Partial Reactions of Oxidative Phosphorylation

    ATPase

    Reversal of Electron Transport

    Lecture 12 Uncouplers and Inhibitors of Oxidative Phosphorylation

    True Uncouplers of Oxidative Phosphorylation

    Inhibitory Uncouplers

    Inhibitors of Oxidative Phosphorylation

    Inhibitors of Oxidation

    Lecture 13 Soluble Factors and Intermediates of Oxidative Phosphorylation

    Nonprotein Factors

    Protein Coupling Factors

    Lecture 14 Theories and Speculations

    Text

    Part III Regulation of Adenosine Triphosphate Utilization in Multi-Enzyme Systems

    Lecture 15 Studies of Reconstructed Multi-Enzyme Systems

    Text

    Lecture 16 Approaches to The Metabolism of Intact Cells and to The Rate-Limiting Factors in Ascites Tumor Cells

    Rate-Limiting Factors in Ascites Tumor Cells

    Lecture 17 Metabolism of Intact Cells

    Rate-Limiting Factors in HeLa Cells

    Rate-Limiting Factors in Leukocytes and Brain

    Rate-Limiting Factors in Muscle

    Lecture 18 Induced Changes in Energy Metabolism

    Text

    Subject Index

Product details

  • No. of pages: 272
  • Language: English
  • Copyright: © Academic Press 1965
  • Published: January 1, 1965
  • Imprint: Academic Press
  • eBook ISBN: 9781483268934

About the Author

Efraim Racker

About the Editor

Anthony San Pietro

Affiliations and Expertise

Indiana University, Bloomington, Indiana, U.S.A.

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