Mechanisms and Manifestations of Obesity in Lung Disease - 1st Edition - ISBN: 9780128135532

Mechanisms and Manifestations of Obesity in Lung Disease

1st Edition

Authors: Richard Johnston Benjamin Suratt
Paperback ISBN: 9780128135532
Imprint: Academic Press
Published Date: 1st October 2018
Page Count: 352
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Mechanisms and Manifestations of Obesity in Lung Disease is a complete resource on the epidemiology and molecular mechanisms related to obesity and lung disease. Obesity has not simply changed the epidemiology of pulmonary disease, it has had a profound impact on the pathophysiology of common pulmonary diseases. As the obesity epidemic has taken hold throughout the developed world, scientists and clinicians are now challenged with identifying the mechanisms by which obesity alters lung health and the pathogenesis of lung diseases. This book is an important new resource for both clinicians and scientists dealing with these new health problems in pulmonary medicine.

Key Features

  • Presents an all-in-one resource that describes the impact of obesity on the development and severity of lung disease
  • Details the molecular and immunologic mechanisms by which obesity impacts the pathogenesis and outcomes of lung disease
  • Includes contributions from authors who are internationally recognized as leaders in the area of obesity and lung disease


Adult and pediatric pulmonologists, adult and pediatric intensivists, Ph.D. scientists, pulmonary and critical care subspecialty fellows, postdoctoral fellows, and graduate students

Table of Contents

1. Obesity and Lung Function
2. Epidemiology of Obesity and Obstructive Airway Diseases
3. Mechanistic Insights from Human Studies of Asthma and COPD
4. The Relevance of Animal Models for the Study of Obesity-Induced Asthma
5. Metabolic Syndrome and Obstructive Sleep Apnea
6. Obesity and Pulmonary Hypertension
7. Obesity and Infectious Diseases
8. Obesity and Acute Lung Injury
9. Adipose Tissue Metabolism in Obesity
10. Metabolic Control of Immune Cells
11. Obesity and the Microbiome
12. Lipoproteins as Inflammatory Mediators
13. Obesity-Induced Mitochondrial Dysfunction and the Risk of Disease


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© Academic Press 2019
Academic Press
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About the Author

Richard Johnston

Richard A. Johnston, Ph.D. is a Research Pharmacologist at the Centers for Disease Control and Prevention in Morgantown, WV. In addition, Dr. Johnston is (1) an Adjunct Associate Professor of Medicine and of Physiology, Pharmacology, and Neuroscience in the School of Medicine at West Virginia University, (2) an Adjunct Associate Professor of Pharmaceutical Sciences in the School of Pharmacy at West Virginia University, and (3) an Associate Member of the West Virginia University Robert C. Byrd Health Sciences Center Graduate Faculty. Dr. Johnston is a member of the American Society for Pharmacology and Experimental Therapeutics, the American Physiological Society, and the American Thoracic Society. As an active member of the American Thoracic Society and for his contributions to pulmonary medicine, Dr. Johnston was recently designated as an American Thoracic Society Fellow. Dr. Johnston has been a member of National Institutes of Health Study Sections and has been a peer reviewer for over fifteen scientific journals. Dr. Johnston’s research career has focused on understanding the impact of obesity or adipocytokines on lung injury, lung inflammation, and airway hyperresponsiveness in response to air pollution or occupational sensitizers.

Affiliations and Expertise

Research Pharmacologist, Centers for Disease Control and Prevention, Morgantown, WV USA

Benjamin Suratt

Dr. Suratt is a Professor of Medicine and Cell & Molecular Biology; Vice Chair of Medicine for Academic Affairs; and the Associate Chief of Pulmonary Disease and Critical Care Medicine in the Department of Medicine at the University of Vermont College of Medicine. He is an active member of over 10 professional organizations including the American Thoracic Society, the Society of Critical Care Medicine, and the American College of Chest Physicians. Dr. Suratt's research career has focused on the role of innate immunity in the pathogenesis of critical illness, particularly ARDS. His recent work has focused on host factors, such as obesity and elements of the metabolic syndrome, and their influence on inflammatory response in the development of and outcomes from critical illness.

Affiliations and Expertise

Professor of Medicine and Cell & Molecular Biology; Vice Chair of Medicine for Academic Affairs; Associate Chief, Pulmonary Disease and Critical Care Medicine; Associate Director, Pulmonary Disease and Critical Care Medicine Fellowship Training Program, Department of Medicine, University of Vermont

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