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Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders - 1st Edition - ISBN: 9780128219133

Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders

1st Edition

Author: Moyra Smith
Paperback ISBN: 9780128219133
Imprint: Academic Press
Published Date: 1st June 2021
Page Count: 300
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Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders connects neurodevelopment with genetics and behavior to better understand the underlying factors to cognitive neurodevelopmental disorders. The book focuses on mechanisms of disease and follows the development of specific brain regions, functions, and gene expression to causes and processes in autism, attention deficit disorder, and learning disabilities. Topics include brain mapping, brain plasticity, epigenetics, neuroimmunology and many other factors that influence the development of these diseases. This book will promote understanding of recent investigations and developments related to brain development from fetal life onwards with specific relevance to neurodevelopmental cognitive disorders and conditions. This is an essential reference for anyone who is looking to learn more about different aspects of neurodevelopment and emerging concepts in psychiatric disorders.

Key Features

  • Discusses links between brain development, gene expression, and brain function
  • Covers neural stem cells, proliferation, migration, differentiation, and neurogenesis
  • Includes brain mapping, brain plasticity, epigenetics, neuroimmunology and more
  • Provides insight into causation and brain function in autism. attention deficit disorder, and learning disabilities
  • Examines impact of society and environmental factors on mental health


Graduate students in biological and biomedical sciences, neuroscientists, clinicians, biomedical scientists, post-doctoral fellows, researchers

Table of Contents

Section I Brain, early development cortices, architecture, cell types, connectivity, networks
1. Early brain development
2. Development and evolution of cerebral and cerebellar cortex
3. White matter development and maturation of connections
4. Brain size
5. Emergence of functional architecture
6. Architectonic mapping beyond Brodman
7. Neuronal cells organization according to transcription
8. Association cortices
9. Cell maps neuronal cell types, classification
10. Development of network hubs
11. Functional and structural connectivity
12. Myelo-architecture
13. Connectome and network theory
14. Hubs modules nodes
15. Microstructure connectomics
16. Dendrites, dendritic spines, spine patterns
17. Networks
18. Distinct metabolic and cytoarchitecture and increased dendritic density in hubs
19. Oligodendrocytes and astrocytes

Section II Neurotransmitters, Neuromodulators. Synapses
20. Neurotransmitters and neuroreceptors, neuromodulators
21. Signalling downstream of receptors
22. Synapses, structure, diversity
23. Post-synaptic interactome
24. Dendrites and transmission
25. Ion channels and channel dynamics
26. Lipids and synaptic function

Section III. Brain Mapping
27. Mapping structural connections forms of imaging
28. Functional connectivity and brain metabolic activity
29. Receptor autoradiography
30. NIH Connectome project

Section IV. Brain Plasticity
31. Neuroplasticity
32. Brain derived neurotrophic factors
33. Dendritic spine dynamics and synaptic plasticity
34. Oligodendrocyte lineage and brain plasticity
35. Mitochondria and brain energy
36. Metabolism and circadian rhythm

Section V. Gene Expression and Regulation in Brain and Epigenetics
37. Signalling pathways
38. Gene transcription
39. Epigenetics and regulation of expression
40. 3D genome and regulation chromatin modifications and dynamics
41. Epigenetics, environmental factors
42. Genomic imprinting and defects potentially impacting development
43. Genomic regulatory elements and transcription

Section VI. Neuroimmunology
44. Neuro-immunology past present and future
45. Brain immune system
46. Micro glia and functions related to immune functions
47. Cytokines and neuromodulators
48. Defined neuroimmune diseases

Section VII. Neurodevelopmental, Neurocognitive and Behavioral Disorders
49. ICD 11 DSM 6 Classification of Pediatric disorders
50. Neuronal activity post-natal neurogenesis and gliogenesis
51. Genomic copy number variants in autism and in neurocognitive disorders Genotype phenotype correlation i 52. copy number disorders
53. Early brain and behavior and development in autism
54. Functional brain connectome in autism
55. Idiopathic autism, studies in derived in pluripotent stem cell derived neurons
56. Gene sequence studies and genome wide association studies in autism
57. Autism genetic and phenotypic heterogeneity
58. Specific genetic defects and Syndromic autism spectrum disorders
59. Non-syndromic autism rare variants
60. Common variants that impact risk in autism spectrum disorders
61. Beyond the exome Noncoding genome and enhancers in neurodevelopment
62. Regulatory elements in neurodevelopmental disorders
63. Chromosome 22q11.2 microdeletion and microduplication and consequent disorders
64. Attention deficit disorders risk variants
65. Cross over in neurobehavioral disorders
66. Intellectual disability inborn errors of metabolism impacting risk nuclear and mitochondrial defects
67. Therapeutic advances

Section VIII Psychiatric diseases
68. DSM and ICD classifications on basis of clinical manifestations
69. Architectural and cellular elements in psychiatric disorders
70. Connectome disruptions in psychiatric diseases
71. Shared heritability in psychiatric disorders
72. NIH brain initiative
73. Future of Psychiatry
74. Treatment of Psychiatric disorders medications, Neurobehavioral therapy
75. Microbiome and potential gut brain interactions
76. Neuromodulation techniques
77. Ethics and Neuroethics in the Brain Initiative

Section IX Health and Wellbeing
78. Environmental factors and epigenetics
79. Nutritional Deficiencies
80. Environment and Stress systems involved in stress responses
81. Social Cognition
82. Ecosystem Ecotherapy
83. Enhancing Neuroplasticity, promoting Resilience

Section X Brain and Mind
84. Concepts and Ideas
85. Environment, Learning, Experience
86. Cultures and Societies


No. of pages:
© Academic Press 2021
1st June 2021
Academic Press
Paperback ISBN:

About the Author

Moyra Smith

Dr. Moyra Smith is a professor emerita in the Department of Pediatrics and Human Genetics, College of Health Sciences, at the University of California, Irvine, and in past years has held appointments at the National Institutes of Health and Johns Hopkins University. In 2017, the UCI Emeriti Association awarded her the UCI Outstanding Emerita Award in recognition of her continuing research on genetics and genomics, her strong record of publications, her mentoring of graduate students, and her involvement with the CART Autism Center at UCI. She has published more than 100 scientific articles in such peer reviewed journals as Frontiers in Molecular Biosciences, Molecular Psychiatry, the American Journal of Medical Genetics—Neuropsychiatric Genetics, and the American Journal of Human Genetics.

Affiliations and Expertise

Professor, Department of Pediatrics and Human Genetics, UCI Institute for Clinical and Translational Science, UCI Campus and Medical Center, University of California Irvine, Irvine, CA, USA

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