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Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders - 1st Edition - ISBN: 9780128219133, 9780128232521

Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders

1st Edition

Author: Moyra Smith
eBook ISBN: 9780128232521
Paperback ISBN: 9780128219133
Imprint: Academic Press
Published Date: 25th April 2021
Page Count: 306
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Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders connects neurodevelopment with genetics and behavior to better understand the underlying factors leading to cognitive neurodevelopmental disorders. This book focuses on mechanisms of disease and follows the development of specific brain regions, functions, and gene expression to causes and processes in autism, attention deficit disorder, and learning disabilities. Topics include brain mapping, brain plasticity, epigenetics, neuroimmunology, and many other factors that influence the development of these diseases.

This book will promote understanding of recent investigations and developments related to brain development from fetal life onward with specific relevance to neurodevelopmental cognitive disorders and conditions. This is an essential reference for anyone who is looking to learn more about different aspects of neurodevelopment and emerging concepts in psychiatric disorders.

Key Features

  • Discusses links between brain development, gene expression, and brain function
  • Covers neural stem cells, proliferation, migration, differentiation, and neurogenesis
  • Includes brain mapping, brain plasticity, epigenetics, neuroimmunology, and more
  • Provides insight into causation and brain function in autism, attention deficit disorder, and learning disabilities
  • Examines impact of society and environmental factors on mental health


Graduate students in biological and biomedical sciences, neuroscientists, clinicians, biomedical scientists, post-doctoral fellows, researchers

Table of Contents

Section I Brain, early development cortices, architecture, cell types, connectivity, networks
1. Early brain development; 2. Development and evolution of cerebral and cerebellar cortex; 3. White matter development and maturation of connections; 4. Brain size; 5. Emergence of functional architecture; 6. Architectonic mapping beyond Brodman; 7. Neuronal cells organization according to transcription; 8. Association cortices; 9. Cell maps neuronal cell types, classification; 10. Development of network hubs; 11. Functional and structural connectivity; 12. Myelo-architecture; 13. Connectome and network theory; 14. Hubs modules nodes; 15. Microstructure connectomics; 16. Dendrites, dendritic spines, spine patterns; 17. Networks; 18. Distinct metabolic and cytoarchitecture and increased dendritic density in hubs; 19. Oligodendrocytes and astrocytes

Section II Neurotransmitters, Neuromodulators. Synapses
20. Neurotransmitters and neuroreceptors, neuromodulators; 21. Signalling downstream of receptors; 22. Synapses, structure, diversity; 23. Post-synaptic interactome; 24. Dendrites and transmission; 25. Ion channels and channel dynamics; 26. Lipids and synaptic function

Section III. Brain Mapping
27. Mapping structural connections forms of imaging; 28. Functional connectivity and brain metabolic activity; 29. Receptor autoradiography; 30. NIH Connectome project

Section IV. Brain Plasticity
31. Neuroplasticity; 32. Brain derived neurotrophic factors; 33. Dendritic spine dynamics and synaptic plasticity; 34. Oligodendrocyte lineage and brain plasticity; 35. Mitochondria and brain energy; 36. Metabolism and circadian rhythm

Section V. Gene Expression and Regulation in Brain and Epigenetics
37. Signalling pathways; 38. Gene transcription; 39. Epigenetics and regulation of expression; 40. 3D genome and regulation chromatin modifications and dynamics; 41. Epigenetics, environmental factors; 42. Genomic imprinting and defects potentially impacting development; 43. Genomic regulatory elements and transcription

Section VI. Neuroimmunology
44. Neuro-immunology past present and future; 45. Brain immune system; 46. Micro glia and functions related to immune functions; 47. Cytokines and neuromodulators; 48. Defined neuroimmune diseases

Section VII. Neurodevelopmental, Neurocognitive and Behavioral Disorders
49. ICD 11 DSM 6 Classification of Pediatric disorders; 50. Neuronal activity post-natal neurogenesis and gliogenesis; 51. Genomic copy number variants in autism and in neurocognitive disorders Genotype phenotype correlation i 52. copy number disorders; 53. Early brain and behavior and development in autism; 54. Functional brain connectome in autism; 55. Idiopathic autism, studies in derived in pluripotent stem cell derived neurons; 56. Gene sequence studies and genome wide association studies in autism; 57. Autism genetic and phenotypic heterogeneity; 58. Specific genetic defects and Syndromic autism spectrum disorders; 59. Non-syndromic autism rare variants; 60. Common variants that impact risk in autism spectrum disorders; 61. Beyond the exome Noncoding genome and enhancers in neurodevelopment; 62. Regulatory elements in neurodevelopmental disorders; 63. Chromosome 22q11.2 microdeletion and microduplication and consequent disorders; 64. Attention deficit disorders risk variants; 65. Cross over in neurobehavioral disorders; 66. Intellectual disability inborn errors of metabolism impacting risk nuclear and mitochondrial defects; 67. Therapeutic advances

Section VIII Psychiatric diseases
68. DSM and ICD classifications on basis of clinical manifestations; 69. Architectural and cellular elements in psychiatric disorders; 70. Connectome disruptions in psychiatric diseases; 71. Shared heritability in psychiatric disorders; 72. NIH brain initiative; 73. Future of Psychiatry; 74. Treatment of Psychiatric disorders medications, Neurobehavioral therapy; 75. Microbiome and potential gut brain interactions; 76. Neuromodulation techniques; 77. Ethics and Neuroethics in the Brain Initiative

Section IX Health and Wellbeing
78. Environmental factors and epigenetics; 79. Nutritional Deficiencies; 80. Environment and Stress systems involved in stress responses; 81. Social Cognition; 82. Ecosystem Ecotherapy; 83. Enhancing Neuroplasticity, promoting Resilience

Section X Brain and Mind
84. Concepts and Ideas; 85. Environment, Learning, Experience; 86. Cultures and Societies


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© Academic Press 2021
25th April 2021
Academic Press
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About the Author

Moyra Smith

Dr. Moyra Smith is Professor Emerita in the Department of Pediatrics and Human Genetics, College of Health Sciences, at the University of California, Irvine, and in past years has held appointments at the National Institutes of Health and Johns Hopkins University. In 2017, the UCI Emeriti Association awarded Dr. Smith the UCI Outstanding Emerita Award in recognition of her continuing research on genetics and genomics, her strong record of publications, her active engagement with programs in the Department of Pediatrics, her mentoring of graduate students, and her involvement with the CART Autism Center at UCI. Dr. Smith has published more than 100 scientific articles in such peer reviewed journals as Frontiers in Molecular Biosciences, Molecular Psychiatry, the American Journal of Medical Genetics - Neuropsychiatric Genetics, and the American Journal of Human Genetics.

Affiliations and Expertise

Division of Genetic and Genomic Medicine, Department of Pediatrics, University of California Irvine, Irvine, CA, United States

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