Developing organisms are systems in which the geometry, dynamics, and boundary conditions are all changing in the course of morphogenesis. The morphogenesis of cells and organisms appear to be mediated in part by the mechanically active components of the cytoskeleton. Mechanical forces have long been considered secondary to the effects of molecular mechanisms in cell growth, differentiation, and development. This volume explores the role of mechanical forces in cell growth and development and demonstrates its importance. This volume will prove invaluable to all biologists interested in the fundamentals of mechanical forces in development, from the advanced to the graduate researcher.


Cell biologists, molecular biologists, developmental biologists, physiologists (organ level), biomedical scientists, biochemists studying cell-cell interactions, cell variation, and evolution; geneticists.

Table of Contents

L.V. Beloussov, S.V. Saveliev, I.I. Naumidi, and V.V. Novoselov, Mechanical Stresses in Embryonic Tissues: Patterns, Morphogenetic Role and Involvement in Regulatory Feedbacks. A.K. Harris, The Locomotion of Tissue Culture Cells, Considered in Relation to Amoeboid Locomotion. D.G. Simpson, W. Carver, T.K. Borg, and L. Terracio, The Role of Mechanical Stimulation in the Establishment and Maintenance of Muscle Cell Differentiation. G.W. Brodland, Finite Element Methods for Developmental Biology. M. Opas, Substratum Mechanics and Cell Differentiation. G. Forgacs and S.A. Newman, Phase Transitions, Interfaces, and Morphogenesis in a Network of Protein Fibers. U. de Boni, The Interphase Nucleus as a Dynamic Structure. D.E. Ingber, L. Dike, L. Hansen, S. Karp, H. Liley, A. Maniotis, H. McNamee, D. Mooney, G. Plopper, J. Sims, and N. Wang, Cellular Tensesgrity: Exploring How Mechanical Changes in the Cytoskeleton Regulate Cell Growth, Migration, and Tissue Pattern during Morphogenesis. B.C. Goodwin and C. Briere, The Mechanics of the Cytoskeleton and Morphogenesis of Acetabularia. R. Gordon, The Chemical Basis for Diatom Morphogenesis. Chapter References. Subject Index.


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© 1994
Academic Press
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@from:Praise for the Series @qu:"Invaluable reading for all biologists." @source:--NATURE @qu:"In keeping with the high standards set by the editors... carefully prepared and edited in the customary fine format and well-illustrated style of Academic Press publications... this series is a significant contribution to a science that impinges on many fields." @source:--THE QUARTERLY REVIEW OF BIOLOGY @qu:"A valuable addition to any college library as current reference material for advanced undergraduates, graduate students, and professional scientists." @source:--CHOICE @qu:"Maintains the tradition and set-up of the previous volumes and certainly provides up-to-date data on varied aspects of cytology... a valuable acquisition to any library." @source:--THE NUCLEUS @qu:"Should be on the shelf of any biomedical library." @source:--Alvin Tesler, Northwestern Medical School, in DOODY'S