Key Features

  • Reviews the earliest clinical and pathological descriptions of multiple sclerosis.
  • Offers a very strong section on pathogenesis.
  • Includes more than 550 high-quality illustrations clarifying important scientific and clinical concepts.
  • Uses a remarkably clear presentation to make complicated data as easy as possible to understand.

Table of Contents

SECTION ONE: THE STORY OF MULTIPLE SCLEROSIS


1. The story of multiple sclerosis

The evolving concept of multiple sclerosis

Naming and classifying the disease: 1868-1983

Clinical descriptions of multiple sclerosis: 1838-1981

Personal accounts of multiple sclerosis: 1824-1991

The social history of multiple sclerosis: 1945-1998

The pathogenesis and clinical anatomy of multiple sclerosis: 1849-1977

The laboratory science of multiple sclerosis: 1912-1981

Discovery of glia and remyelination: 1858-1988

The aetiology of multiple sclerosis: 1883-1976

Attitudes to the treatment of multiple sclerosis: 1841-1983


SECTION TWO: THE CAUSE AND COURSE OF MULTIPLE SCLEROSIS


2. The distribution of multiple sclerosis

The rationale for epidemiological studies in multiple sclerosis

Definitions and statistics in epidemiology

Strategies for epidemiological studies in multiple sclerosis

The geography of multiple sclerosis

Epidemics and clusters of multiple sclerosis

The environmental factor in multiple sclerosis


3. The genetics of multiple sclerosis:

Genetic analysis of multiple sclerosis

Methods of genetic analysis

Racial susceptibility

Sex differences in susceptibility

Familial multiple sclerosis

Candidate genes in multiple sclerosis

Systematic genome screening

Lessons from genetic studies of experimental allergic encephalomyelitis

Conclusions


4. The natural history of multiple sclerosis

Introduction

Definitions

Onset

Course

Inter-individual variability

Factors affecting the prognosis

General considerations

Environmental influences


Chapter 5: The aetiology of multiple sc

Details

No. of pages:
992
Language:
English
Copyright:
© 2006
Published:
Imprint:
Churchill Livingstone
Print ISBN:
9780443072710
Electronic ISBN:
9780702031922

About the authors

Alastair Compston

Affiliations and Expertise

Professor of Neurology, University of Cambridge, Cambridge, UK

Ian McDonald

Affiliations and Expertise

University of Cambridge

John Noseworthy

Affiliations and Expertise

Chair, Department of Neurology, Mayo Clinic, Rocherster, MN

Hans Lassmann

Affiliations and Expertise

Professor of Neuropathology, Institute of Neurology, University of Vienna, Vienna, Austria

David Miller

Affiliations and Expertise

Professor of Clinical Neurology, Institute of Neurology; Consultant Neurologist, The National Hospital for Neurology and Neurosurgery, London

Kenneth Smith

Affiliations and Expertise

Department of Neuroimmunology, Guy's King's & St. Thomas' School of Medicine, London, UK

Hartmut Wekerle

Affiliations and Expertise

Director, Max-Planck-Institut fur Psychiatrie (Theoretisches Institut), Martinsried, Germany

Christian Confavreux

Affiliations and Expertise

Service de Neurologie, Hopital Neurologique, BP Lyon Montchat, France