Description

The chapters in this book thoroughly cover the structure, regulation, and function of matrix metalloproteinases, and provide information on the latest strategies to inhibit enzyme activity. This work will be an indispensable reference tool for investigators with an interest in extracellular matrix biology, matrix turnover, enzymology and biochemistry of proteinases, developmental biology, pathology, and therapeutic interventions.

Key Features

@introbul:Key Features @bul:* Provides state-of-the-art information on a field with broad implications to many areas of biology * Includes detailed coverage of the structure and regulation of all major matrix metalloproteinases * Chapters focus on a timely and expanding field * Topics have direct relevance to understanding human disease pathology of cancer, arthritis, and vascular disease * Discusses latest strategies used in the development of new therapeutics to inhibit metalloproteinase activity

Readership

Graduate students and researchers in cell biology, cancer biology, molecular biology, biochemistry departments. Scientists and physicians with an interest in the pathogenesis of cancer, arthritis, wound healing, and vascular disease. Researchers and product design scientists in the pharmaceutical and biotechnology industries.

Table of Contents

Contributors. Preface. The Matrix Metalloproteinase Family, J.F. Woessner, Jr.. Interstitial Collagenases, J.J. Jeffrey. Stromelysins 1 and 2, H. Nagase. 72-kDa Gelatinase (Gelatinase A): Structure, Activation, Regulation, and Substrate Specificity, A.E. Yu, A.N. Murphy and W.G. Stetler-Stevenson. Gelatinase B: Structure, Regulation, and Function, T.H. Vu and Z. Werb. Matrilysin, C.L. Wilson and L.M. Matrisian. Macrophage Elastase (MMP-12), S.D. Shapiro and R.M. Senior. Membrane-Type Matrix Metalloproteinases and Cell Surface-Associated Activation Cascades for Matrix Metalloproteinases, V. Knauper and G. Murphy. Substrate Specificity and Mechanism of Substrate Recognition of the Matrix Metalloproteinases, V. Imper and H.E. Van Wart. Synthetic Inhibitors of Matrix Metalloproteinases, P.D. Brown. Matrix Metalloproteinases in Tissue Repair, W.C. Parks, B.D. Sudbeck, G.R. Doyle and U.K. Saariahlo-Kere. Regulation of Matrix Metalloproteinase Gene Expression, M.E. Fini, J.R. Cook, R. Mohan and C.E. Brinckerhoff. Index.

Details

No. of pages:
362
Language:
English
Copyright:
© 1998
Published:
Imprint:
Academic Press
Electronic ISBN:
9780080535982
Print ISBN:
9780125450904
Print ISBN:
9780123911834

Reviews

@qu:"It is an encyclopedia and up-to-date compendium of the minute details of the literature on all characterized MMPs for specialists in this field... would I buy it? Yes." @source:--CELL @qu:"In all, this book is a very comprehensive coverage of the specialized area of MMPs. The editors and contributors describe not only the current status of research being conducted in this field, but also speculate on the future direction of that research." @source:--DOODY'S PUBLISHING REVIEWS