
Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Cardiovascular Remodeling
Description
Key Features
- Focuses on matrix metalloproteinases and their role in tissue remodeling under physiological and pathological conditions
- Contains up-to-date information on matrix metalloproteinases that is clearly presented in a concise fashion with helpful illustrations and supporting references
- Includes comprehensive reviews written by prominent scientists and highly-recognized experts in the field of matrix metalloproteinases and tissue remodeling
Readership
Table of Contents
Chapter One: Biochemical and Biological Attributes of Matrix Metalloproteinases
N. Cui, M. Hu and R.A. Khalil- Abstract
- 1 Introduction
- 2 MMP Structure
- 3 Sources and Tissue Distribution of MMPs
- 4 MMP Activation
- 5 MMP Substrates
- 6 MMPs, ECM Degradation, and Tissue Remodeling
- 7 MMPs and Cell Signaling
- 8 Special Attributes of Specific MMPs
- 9 MMP/TIMP Ratio
- 10 Concluding Remarks
- Acknowledgments
Chapter Two: Matrix Metalloproteinases in Myocardial Infarction and Heart Failure
K.Y. DeLeon-Pennell, C.A. Meschiari, M. Jung and M.L. Lindsey- Abstract
- 1 Introduction
- 2 MMPs as Biomarkers for Heart Failure
- 3 Clinical Use of MMP Inhibitors Post-MI
- 4 Future Directions
- 5 Conclusion
- Acknowledgments
Chapter Three: The Balance Between Metalloproteinases and TIMPs: Critical Regulator of Microvascular Endothelial Cell Function in Health and Disease
M.G. Masciantonio, C.K S. Lee, V. Arpino, S. Mehta and S.E. Gill- Abstract
- 1 Introduction
- 2 Metalloproteinases
- 3 Tissue Inhibitor of Metalloproteinases
- 4 Microvascular Endothelial Cells
- 5 MVEC Dysfunction
- 6 Metalloproteinases in Endothelial Dysfunction
- 7 TIMPs in Endothelial Dysfunction
- 8 Conclusion
Chapter Four: Matrix Metalloproteinases and Platelet Function
P. Gresele, E. Falcinelli, M. Sebastiano and S. Momi- Abstract
- 1 Platelets: Structure and Function
- 2 Expression of MMPs by Platelets and Megakaryocytes
- 3 Functions of MMPs in Platelets and Megakaryocytes
- 4 Role of Platelet-Derived MMPs in Disease
- 5 Conclusions
Chapter Five: Matrix Metalloproteinases and Leukocyte Activation
K.S. Smigiel and W.C. Parks- Abstract
- 1 Introduction
- 2 Inflammation and Tissue Remodeling
- 3 Neutrophils, Macrophages, and Lymphocytes
- 4 MMP Regulation of Leukocyte Activity
- 5 Concluding Remarks
Chapter Six: Evidence for the Involvement of Matrix-Degrading Metalloproteinases (MMPs) in Atherosclerosis
B.A Brown, H. Williams, and S.J George- Abstract
- 1 Atherosclerosis and Cardiovascular Disease
- 2 Introduction to MMPs
- 3 TIMPs
- 4 Conclusion
Chapter Seven: The Role Matrix Metalloproteinases in the Production of Aortic Aneurysm
S.W Rabkin- Abstract
- 1 Introduction
- 2 TAA and Dissection (TAD)
- 3 Abdominal Aortic Aneurysm (AAA)
- 4 Putative Signaling Pathways Involved in Aortic Aneurysm Development: Relationship to MMPs
- 5 Cigarettes and AAA Development
- 6 MMP Substrates and Pathogenesis of Aortic Aneurysm
- 7 Summary
Chapter Eight: Matrix Metalloproteinases in Remodeling of Lower Extremity Veins and Chronic Venous Disease
Y. Chen, W. Peng, J.D. Raffetto and R.A. Khali- Abstract
- 1 Introduction
- 2 Chronic Venous Disease (CVD)
- 3 Structural and Functional Abnormalities in VVs
- 4 MMP Levels in VVS
- 5 Potential MMP Inducers/Activators in VVs
- 6 Mechanisms of MMP Actions in VVs
- 7 Management of VVs
- 8 Potential Benefits of MMP Inhibitors in VVs
- 9 Concluding Remarks
- Acknowledgments
Product details
- No. of pages: 320
- Language: English
- Copyright: © Academic Press 2017
- Published: April 14, 2017
- Imprint: Academic Press
- Hardcover ISBN: 9780128116371
- eBook ISBN: 9780128116388
About the Serial Volume Editor
Raouf Khalil

Affiliations and Expertise
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