Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic, Gaze Orienting Mechanisms and Disease

Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic, Gaze Orienting Mechanisms and Disease

1st Edition - July 18, 2019

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  • Editors: R John Leigh, Stefano Ramat, Aasef Shaikh
  • Hardcover ISBN: 9780444642547
  • eBook ISBN: 9780444642554

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Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic, Gaze Orienting Mechanisms and Disease, Volume 249, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Sequential Bayesian updating, Maps and Sensorimotor Transformations for Eye-Head Gaze Shifts: Role of the Midbrain Superior Colliculus, Modeling Gaze Position-Dependent Opsoclonus, Eye Position-Dependent Opsoclonus in Mild Traumatic Brain Injury, Saccades in Parkinson's disease -- hypometric, slow, and maladaptive, Brainstem Neural Circuits for Fixation and Generation of Saccadic Eye Movements, and much more.

Key Features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the Progress in Brain Research series
  • Includes the latest information on mathematical modeling in motor neuroscience


Postgraduates and researchers in the area of mathematical modelling, motor neuroscince and neuroscience in general

Table of Contents

  • Section I -DIDACTIC: Modeling
    1. Sequential Bayesian updating as a model for human perception
    Stefan Glasauer
    2. Maps and sensorimotor transformations for eye-head gaze shifts: Role of the midbrain superior colliculus
    A. John van Opstal and Bahadir Kasap
    3. Modeling gaze position-dependent opsoclonus
    Lance M. Optican, Janet C. Rucker, John-Ross Rizzo and Todd E. Hudson

    Section II - DIDACTIC: Translational
    4. Eye position-dependent opsoclonus in mild traumatic brain injury
    John-Ross Rizzo, Todd H. Hudson, Alexandra J. Sequeira, Weiwei Dai, Yash Chaudhry, John Martone, David S. Zee, Lance M. Optican, Laura J. Balcer, Steven L. Galetta and Janet C. Rucker

    Section III - RESEARCH: Saccades
    5. Saccades in Parkinson’s disease: Hypometric, slow, and maladaptive
    Aasef G. Shaikh and Fatema F. Ghasia
    6. Brainstem neural circuits for fixation and generation of saccadic eye movements
    Yoshikazu Shinoda, Mayu Takahashi and Yuriko Sugiuchi
    7. Morphological and electrophysiological characteristics of the commissural system in the superior colliculi for conrol of eye movements
    Mayu Takahashi
    8. Potassium channels in omnipause neurons
    Ümit S Mayadali, Karoline Lienbacher, Michael Mustari, Michael Strupp and Anja KE Horn
    9. The cerebellum improves the precision of antisaccades by a latency-duration trade-off
    Pietro Piu, Elena Pretegiani, Francesca Rosini, Valeria Serchi, Domenica Zaino, Tommaso Chiantini and Alessandra Rufa
    10. Saccade variability in healthy subjects and cerebellar patients
    Eggert T and Straube A
    11. Electrical stimulation in a spiking neural network model of monkey superior colliculus
    A. John van Opstal and Bahadir Kasap

    Section IV - RESEARCH: Adaptation
    12. A neuronal process for adaptive control of primate saccadic system
    Yoshiko Kojima
    13. A unified computational framework for visual attention dynamics
    Dario Zanca, Marco Gori and Alessandra Rufa
    14. Improving the repeatability of two-rate model parameter estimations by using autoencoder networks
    Ozdemir MC, Eggert T and Straube A

    Section V - RESEARCH: Nystagmus
    15. Rebound nystagmus, a window into the oculomotor integrator
    Jorge Otero-Millan, Ayse I. Colpak, Amir Kheradmand and David S. Zee
    16. Central positional nystagmus: Characteristics and model-based explanations
    Jeong-Yoon Choi and Ji-Soo Kim
    17. Modulation of acquired monocular pendular nystagmus in multiple sclerosis: A modeling approach
    Ileok Jung, Sung-Hee Kim, Hyo-Jung Kim, Jeong-Yoon Choi and Ji-Soo Kim
    18. Fixation instability in amblyopia: Oculomotor disease biomarkers predictive of treatment effectiveness
    M. Scaramuzzi, J. Murray, J. Otero-Millan, Paolo Nucci, A.G. Shaikh and F.F. Ghasia

    Section VI - RESEARCH: Dystonia
    19. What can kinematic studies tell us about the mechanisms of dystonia?
    Anna Sadnicka, Joseph Galea and Mark J. Edwards
    20. Implications of asymmetric neural activity patterns in the basal ganglia outflow in the integrative neural network model for cervical dystonia
    Alexey Sedov, Ulia Semenova, Svetlana Usova, Alexey Tomskiy, J. Douglas Crawford, H.A. Jinnah and Aasef G. Shaikh
    21. A motor control model of task-specific dystonia and its rehabilitation
    Anna Sadnicka and Jaume Rosset-Llobet
    22. Tremor in chronic inflammatory demyelinating polyneuropathy: Proof of unifying network model for dystonia
    Nataliya Pyatka, Alexey Sedov, Benjamin L. Walter, H.A. Jinnah and Aasef G. Shaikh

    Section VII - RESEARCH: Parkinson's disease
    23. Oculomotor effects of medical and surgical treatments of Parkinson’s disease
    Salil Patel, James J. Fitzgerald and Chrystalina A. Antoniades
    24. Vestibular heading perception in Parkinson's disease
    Sinem Balta Beylergil, Sarah Ozinga, Mark F. Walker, Cameron McIntyre and Aasef G. Shaikh
    25. A new approach for estimation of spiketrain patterns in basal ganglia
    Vladislav Myrov, Alexey Sedov, Alexey Tomskiy, Ludmila Myrova and Elena Belova

    Section VIII - RESEARCH: Others
    26. A model-based study of internuclear ophthalmoparesis and ocular-motor fatigue in multiple sclerosis
    Jonathan B. Jacobs, Clara Chisari, Margaret M. Skelly, Mark F. Walker and Alessandro Serra
    27. Central positional vertigo: A clinical-imaging study
    Emiliano De Schutter, Zachariah O. Adham and Jorge C. Kattah
    28. Eye-hand re-coordination: A pilot investigation of gaze and reach biofeedback in chronic stroke
    John-Ross Rizzo, Mahya Beheshti, Azadeh Shafieesabet, James Fung, Maryam Hosseini, Janet C. Rucker, Lawrence H. Snyder and Todd E. Hudson
    29. Kinematics and the neurophysiological study of visually-guided eye movements
    Laurent Goffart
    30. Deficient head motor control in functional dizziness: Experimental evidence of central sensory-motor dysfunction in persistent physical symptoms
    Nadine Lehnen, Lena Schröder, Peter Henningsen, Stefan Glasauer and Cecilia Ramaioli

Product details

  • No. of pages: 426
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: July 18, 2019
  • Imprint: Academic Press
  • Hardcover ISBN: 9780444642547
  • eBook ISBN: 9780444642554

About the Serial Volume Editors

R John Leigh

John Leigh worts at Case Western Reserve University in Cleveland.

Affiliations and Expertise

Case Western Reserve University, Cleveland, OH, USA

Stefano Ramat

Stefano Ramat currently works at the Dip. Ingegneria Industriale e dell'Informazione, University of Pavia. Stefano does research in Bioengineering, Motor Neuroscience, Algorithms, Artificial Neural Network and Medical Devices. Their current project is 'Functional Vestibular Testing'

Affiliations and Expertise

Professor of Bioengineering, University of Pavia, Italy

Aasef Shaikh

Aasef G. Shaikh works at University Hospitals Cleveland Medical Center in Cleveland.

Affiliations and Expertise

University Hospitals Cleveland Medical Center, Cleveland, USA

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