Immunization during pregnancy with currently recommended vaccines prevents infection in the mother, the unborn fetus, and the young infant, and there is an increasing focus from different stakeholders to use this approach for other infections of importance to protect these vulnerable groups. The aim of this Maternal Immunization book is to provide a contemporary overview of vaccines used in pregnancy (and the lactation period), with emphasis on aspects of importance for the target groups, namely, rationale for the use of vaccines in pregnancy, safety, immunogenicity (immunology), timing to vaccinate, repeat doses, protective effects in the mother, fetus, and infant, and public acceptance and implementation, of existing and of future vaccines.
- Provides an overview of a quickly evolving topic. This will benefit the reader who wishes to rapidly become informed and up-to-date with new developments in this field
- Suitable to a broad audience: scientific researchers, obstetricians, gynecologists, neonatologists, vaccinators, pediatricians, students, and industry. Maternal vaccination impacts a wide range of specialists
- Allows health care professionals/researchers to gain insight into other aspects of vaccination in pregnancy outside of their specialism
- Is coauthored by specialists from multiple disciplines, providing a diverse view of the subject, increasing its interest and appeal
- Creates awareness of the current developments in this area of medicine and of the potential of maternal vaccination to improve the health of mothers and infants worldwide
Microbiologists, healthcare professionals, including obstetricians, pediatricians, neonatologists, and midwives; students, lecturers, academic researchers and other medically or scientifically trained people
Part A: Cross-cutting chapters
A1/ Immunobiological aspects of vaccines in pregnancy: implications for the mother - timing of vaccination, immune response in pregnancy, placental transfer of antibody
A2/ Immunobiological aspects of vaccines in pregnancy: implications for the fetus and infant: Effect on infant response to vaccination, breast milk
A3/ Clinical vaccine trial conduct in pregnancy (assessment of safety/ monitoring/ regulatory aspects)
A4/ Social acceptance and uptake
Part B: Existing vaccines for use in pregnancy: Harmonised chapter format, focussing on burden of disease (including in high-income and low-middle income countries), epidemiology, current recommendations of use, evidence of effectiveness/ efficacy in women and infants and future prospects
B4/ Other existing vaccines with recommendations in particular circumstances (for example travel and outbreak control), for example Hepatitis A and B, meningococcal & pneumococcal vaccination.
Part C: Future vaccines for use in pregnancy or before conception: Harmonised chapter format, focussing on burden of disease (including in high-income and low-middle income countries), epidemiology, development of vaccination, available evidence of efficacy, future prospects.
- No. of pages:
- © Academic Press 2020
- 1st December 2019
- Academic Press
- Paperback ISBN:
Dr Elke Leuridan is a medical doctor who is currently working within the Vaccine and Infectious Diseases Institute, Centre for the Evaluation of Vaccination, University of Antwerp, Belgium. She completed her M.D. degree from the Catholic University of Leuven, Belgium. After several years in clinical practice, including residencies in obstetrics and internal medicine, she joined in 2002 the Centre for the Evaluation of Vaccination. She first combined research with clinical work in a health house for prostitutes. In 2012 she defended a PhD thesis on ‘Vaccine preventable diseases and maternal antibodies’. As postdoctoral researcher, she supervises several projects on (pertussis) vaccination during pregnancy in Belgium and abroad (Vietnam, Thailand). She is the promoter of several PhD students on the topic. She is involved in the training of medical students and supervises yearly several master and advanced master theses. Since 2015, she combines working in research with general practice. Additionally, she is the coordinator of an international summer school on vaccinology, yearly organized at the University of Antwerp; 30 to 40 (pre-)graduate (para)medical students participate annually. She is in charge of the scientific program, contact with speakers, logistics and recruitment of participants, organization of financial support and she teaches as well. She is member of the Belgian National Health Council, working group vaccination, and participates in the decision making process on current and future immunization programs in Belgium. She is a member of ESPID (European Society of Pediatric Infectious Diseases).
Associate Professor, Centre for the Evaluation of Vaccinations, Vaccine and Infectious diseases Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Belgium
Dr. Marta C Nunes is a senior scientist at the Meningeal Pathogens Research Unit (RMPRU) based at the Chris Hani Baragwanath Academic Hospital, Soweto, South Africa. Marta developed her PhD thesis work in Prof S Goldman's laboratory at the Department of Neurology & Neuroscience, Weill Medical College of Cornell University, New York, USA and obtained her PhD from the University of Lisbon, Medical College, Lisbon, Portugal in January 2004. To approach the problem of infant morbidity related to infections from a different angle she is exploring the potential of intervening through vaccination of pregnant women to protect the women and their babies against infections. This also includes the evaluation of the impact of preventing respiratory illnesses in pregnant women on reducing adverse birth outcomes such as premature birth, stillbirths and low-birth weight. Under her supervision RMPRU has conducted 2 large randomized-placebo-control trials of maternal influenza vaccination (2011-2012) and a third trial (2013) in HIV-infected women using different vaccination regimens.
Senior Researcher, Respiratory And Meningeal Pathogens Research Unit, University of the Witwatersrand, Johannesburg, South Africa
Dr Chrissie Jones is an Honorary Senior Lecturer and Consultant in Paediatric Infectious Disease. Her research focusses on interventions to prevent infection in early life.
Associate Professor and Honorary Consultant in Paediatric Infectious Diseases, Faculty of Medicine and Institute for Life Sciences, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK