This book contains full papers of both oral and poster presentations of the international symposium 'Marine Bioprocess Engineering' which was held in Noordwijkerhout, The Netherlands, 1998. The symposium focused on the bioprocessing of marine natural products.
Bioprocess engineering has been the key to success in the commercialization of biotechnology, especially with respect to biopharmaceuticals. In marine biotechnology, both new and existing biotechnological techniques are developed an applied to organisms from marine sources. For marine biotechnology, bioprocess engineering represents the link between discovery and commercialization.
The diversity of marine life points to a myriad of new bioproducts waiting to be discovered and developed commercially.
The volume begins to bridge the gap between the isolation of products from marine organisms in the laboratory and industrial applications by focusing on the bioprocess-engineering aspects. Reviews and recent developments in product discovery, bio-energy production, cultivation of marine organisms, scale up and product recovery are presented.
This publication should ensure that the engineering aspects of marine biotechnology will receive further attention in the future. Exploration of new bioproducts from the ocean should be followed up by a sustainable exploitation of these valuable resources.

Table of Contents

Editorial. Opening keynote. The bioprocess- technological potential of the sea (S.A. Pomponi). Products. The discovery and development of marine compounds with pharmaceutical potential (M.H.G. Munro, J.W. Blunt, E.J. Dumdei, S.J.H. Hickford, R.E. Lill, S. Li, C.N. Battershill and A.R. Duckworth). Microbial antagonism: a neglected avenue of natural products research (J.G. Burgess, E.M. Jordan, M. Bregu, A. Mearns-Spragg, K.G. Boyd). Screening of marine microalgae for bioremediation of cadmium-polluted seawater (T. Matsunaga, H. Takeyama, T. Nakao, A. Yamazawa). Diatom silicon biomineralization as an inspirational source of new approaches to silica production (E.G. Vrieling, T.M.P. Beelen, R.A. van Santen, W.W.C. Gieskes). Biosynthesis and properties of an extracellular metalloprotease from the Antarcic marine bacterium Sphingomonas paucimobilis (M. Turkiewicz, E. Gromek, H. Kalinowska, M. Zielińska). Cyanobacteria - a potential source of new biologically active substances (S. Kreitlow, S. Mundt, U. Lindequist). Biodiversity and potentials of marine-derived microorganisms (F. Sponga, L. Cavaletti, A. Lazzarini, A. Borghi, I. Ciciliato, D. losi, and F. Marinelli). Production and particle characterization of the frustules of Cyclotella cryptica in comparison with siliceous earth (Z. Csögör, D. Melgar, K. Schmidt, C. Posten). Biotechnological potential of North Sea salt marsh plants - a review of traditional knowledge (G. Liebezeit, T.D. Künnemann, G. Gad). The pharmaceutical exploration of cold water ascidians from the Netherlands: a possible source of new cytotoxic natural products (A. Koulman, L.M.C. Prujijn, T.S.A. Sandstra, H.J. Woerdenbag, N. Pras). Energy. Biotechnological hydrogen production: research for efficient light energy conversion (J. Miyake, M. Miyake, Y. Asada). Substrate consumption rates for hydrogen production by Rhodobacter sphaeroides


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© 1999
Elsevier Science
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