Marihuana Biological Effects

Marihuana Biological Effects

Analysis, Metabolism, Cellular Responses, Reproduction and Brain

1st Edition - October 30, 1979

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  • Editors: Gabriel G. Nahas, William D. M. Paton
  • eBook ISBN: 9781483158044

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Marihuana Biological Effects: Analysis, Metabolism, Cellular Responses, Reproduction and Brain contains the proceedings of the Satellite Symposium of the 7th International Congress of Pharmacology held at Paris on July 22-23, 1978. Organized into four parts, this book begins with a discussion on the quantification of cannabinoids and their metabolites in the body fluids and tissues. Part II describes the cannabinoids and cellular metabolism. Parts III and IV explain the effects of cannabis on reproduction and brain.

Table of Contents

  • Contents

    List of Participants



    Marihuana and The Cell—Gabriel Nahas

    I. Quantification of Cannabinoids and their Metabolites in Body Fluids and Tissues: Pharmacokinetics

    Introduction to Quantification of Cannabinoids and their Metabolites in Biological Fluids

    Applications of Mass Spectrometry in Cannabinoid Research

    Identification and Measurement of Cannabinoids and their in Vivo Metabolites in Liver by Gas Chromatography—Mass Spectrometry

    Relation Between Effects of Cannabinoid Derivatives On The Twitch Response of the Isolated Guinea Pig Ileum and their Psychotropic Properties

    Delta-7-Tetrahydrocannabinol, A Non-Psychotropic Cannabinoid: Structureactivity Considerations in the Cannabinoid Series

    The Radioimmunoassay of Cannabinoids; Its Clinical, Pharmacological and Forensic Applications

    Determination of Cannabinoids in Urine by Emit Homogenous Enzyme Immunoassay

    In Vitro Metabolism of Tetrahydrocannabinol by Rhesus Monkey Liver and Human Liver

    Pharmacokinetics and Disposition of Delta-9-Tetrahydrocannabinol and Its Metabolites

    Summary of Session

    II. Cannabinoids and Cellular Metabolism

    A. Isolated Cell Preparations

    Inhibitory Effects of Delta-9-Tetrahydrocannabinol and Other Psychotropic Drugs On Cultured Lymphocytes

    Inhibition by Thc of Thymidine Transport: A Plasma Membrane Effect

    Effect of Delta-9-Tetrahydrocannabinol in Nucleoside and Amino Acid Uptake in Reuber H35 Hepatoma Cells

    Cannabinoids: The Influence On Cell Proliferation and Macromolecular Biosynthesis

    Difference in Response to Vitamin C Between Marihuana and Tobacco Smoke Exposed Human Cell Cultures

    Marihuana and Cell Function—R. A. Carchman

    Effect of (—) Delta-9-THC On ATPase Systems From Various Sources

    (—)Trans-Delta-9-Tetrahydrocannabinol: Synaptosomal Phospholipids, Synaptosomal Plasma Membrane (Na+-K+)-ATPase, and Thiopentone Anaesthesia in Mice

    Biochemical Alterations Induced by Cannabinoids in the Leydig Cells of the Rat Test Is in Vitro: Effects On Testosterone and Protein Synthesis

    Influence of Delta-9-Tetrahydrocannabinol On Contraction Rate and Enzymatic Activity of Embryonic Heart Cells

    B. In Vivo Preparations

    Effects of Cannabis On Lungs

    An Experimental Animal Model For Quantifying the Biologic Effects of Marijuana on the Defense System of the Lung

    Cannabinoids and Membrane-Bound Enzymes

    The Effects of Cannabinoids On Rat Brain Synaptosomes

    The Effect of in Vivo Treatment With ( — ) Delta-1-Tetrahydrocannabinol, and other Psychoactive Drugs On the in Vitro Uptake of Biogenic Amines

    Long Term Effects of Delta-9-Tetrahydrocannabinol in Mice

    Hypoploid Metaphases in Cultured Lymphocytes of Marihuana Smokers

    Observations in Chronic Hashish Users: Nuclear Aberrations in Blood and Sperm and Abnormal Acrosomes in Spermatozoa

    Summary of Session II

    III. Cannabis and Reproduction

    Effects of Cannabis On Sex Hormones and Testicular Enzymes of The Rodent

    Effects of Cannabinoids On Spermatogenesis in Mice

    Effects of Marihuana Inhalation On Spermatogenesis of The Rat

    Changes in Human Spermatozoa Associated With High Dose Marihuana Smoking

    Effects of Cannabinoids On Reproductive Organs in the Female Fischer Rat

    Effect of Delta-9-Tetrahydrocannabinol (Thc) On Female Reproductive Function

    The Effect of A Crude Marihuana Extract On Embryonic and Foetal Development of the Rabbit

    Effects of Cannabis On Fetal Development of Rodents

    Reproduction in Rhesus Monkeys Chronically Exposed to Delta-9-THC

    Summary of Session III

    IV. Cannabis and The Brain

    Ultrastructural and Biochemical Changes in Cns Induced by Marihuana

    Brain Biochemical Alterations in Neonates of Dams Treated Orally Withdelta

    Cannabis and The Brain With Special Reference to The Limbic System

    Cannabis and Brain-Stimulation Reward

    Cannabis and The Development of Tolerance

    Pharmacological Similarities and Interactions Between Cannabis and Opioids

    Delta-9-Tetrahydrocannabinol and the Quasi-Morphine Withdrawal Syndrome

    Cannabis and Epilepsy

    Marihuana and Epilepsy: Paradoxical Anticonvulsant and Convulsant Effects

    Effects of Cannabis On Human EEGn

    Effects of Marihuana On Pain and Verbal Memory: A Sensory Decision Theory Analysis

    Residual Effects of High-Dose Cannabis Treatment On Learning, Muricidal Behavior ad Neurophysiological Correlates in Rats

    Social Behavior of Rhesus Monkeys Chronically Exposed to Moderate Amounts of Delta-9-Tetrahydrocannabinol

    Chronic Marihuana Smoking: Its Effect On Function and Structure of the Primate Brain

    Summary of Session IV

    Concluding Summary

    Appendix—Cannabis and Alcohol: The Green and The Red

    Author Index

    Subject Index

Product details

  • No. of pages: 798
  • Language: English
  • Copyright: © Pergamon 1979
  • Published: October 30, 1979
  • Imprint: Pergamon
  • eBook ISBN: 9781483158044

About the Editors

Gabriel G. Nahas

William D. M. Paton

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