Marihuana Biological Effects

1st Edition

Analysis, Metabolism, Cellular Responses, Reproduction and Brain

Editors: Gabriel G. Nahas William D. M. Paton
Hardcover ISBN: 9780080237596
eBook ISBN: 9781483158044
Imprint: Pergamon
Published Date: 30th October 1979
Page Count: 798
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Marihuana Biological Effects: Analysis, Metabolism, Cellular Responses, Reproduction and Brain contains the proceedings of the Satellite Symposium of the 7th International Congress of Pharmacology held at Paris on July 22-23, 1978. Organized into four parts, this book begins with a discussion on the quantification of cannabinoids and their metabolites in the body fluids and tissues. Part II describes the cannabinoids and cellular metabolism. Parts III and IV explain the effects of cannabis on reproduction and brain.

Table of Contents

Contents List of Participants Foreword Introduction Marihuana and The Cell—Gabriel Nahas I. Quantification of Cannabinoids and their Metabolites in Body Fluids and Tissues: Pharmacokinetics Introduction to Quantification of Cannabinoids and their Metabolites in Biological Fluids Applications of Mass Spectrometry in Cannabinoid Research Identification and Measurement of Cannabinoids and their in Vivo Metabolites in Liver by Gas Chromatography—Mass Spectrometry Relation Between Effects of Cannabinoid Derivatives On The Twitch Response of the Isolated Guinea Pig Ileum and their Psychotropic Properties Delta-7-Tetrahydrocannabinol, A Non-Psychotropic Cannabinoid: Structureactivity Considerations in the Cannabinoid Series The Radioimmunoassay of Cannabinoids; Its Clinical, Pharmacological and Forensic Applications Determination of Cannabinoids in Urine by Emit Homogenous Enzyme Immunoassay In Vitro Metabolism of Tetrahydrocannabinol by Rhesus Monkey Liver and Human Liver Pharmacokinetics and Disposition of Delta-9-Tetrahydrocannabinol and Its Metabolites Summary of Session II. Cannabinoids and Cellular Metabolism A. Isolated Cell Preparations Inhibitory Effects of Delta-9-Tetrahydrocannabinol and Other Psychotropic Drugs On Cultured Lymphocytes Inhibition by Thc of Thymidine Transport: A Plasma Membrane Effect Effect of Delta-9-Tetrahydrocannabinol in Nucleoside and Amino Acid Uptake in Reuber H35 Hepatoma Cells Cannabinoids: The Influence On Cell Proliferation and Macromolecular Biosynthesis Difference in Response to Vitamin C Between Marihuana and Tobacco Smoke Exposed Human Cell Cultures Marihuana and Cell Function—R. A. Carchman Effect of (—) Delta-9-THC On ATPase Systems From Various Sources (—)Trans-Delta-9-Tetrahydrocannabinol: Synaptosomal Phospholipids, Synaptosomal Plasma Membrane (Na+-K+)-ATPase, and Thiopentone Anaesthesia in Mice Biochemical Alterations Induced by Cannabinoids in the Leydig Cells


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© Pergamon 1979
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About the Editor

Gabriel G. Nahas

William D. M. Paton