Here's complete, practical guidance on the evaluation of the surgical pathology specimen, from its arrival in the department to preparation of the final report. Inside, readers will find step-by-step instructions on specimen processing, tissue handling, gross dissection technique, histological examination, application of special stains, development of a differential diagnosis, and more. This thoroughly revised New Edition integrates cutting-edge techniques as well as the latest staging and classification information.

Key Features

  • Features more than 150 tables that examine the interpretation of histochemical stains, immunohisto-chemical studies, electron microscopy findings, cytogenetic changes, and much more.
  • Makes information easy to find with a user-friendly design, concise paragraphs, numbered lists, and bulleted material throughout the text.
  • Offers detailed instructions on the dissection, description, and sampling of specimens.
  • Provides the latest criteria for the grading and AJCC classification of all major tumors.
  • Examines the specimens from every body organ and system as well as bullets, medical devices, and foreign materials.
  • Explains the application of pathology reports to patient management.
  • Includes useful guidance on operating room consultations, safety, microscope use, and error prevention.
  • A superb source of step-by-step, bench-top guidance and an excellent board review guide.

Table of Contents

1. Requests for Pathologic Specimens

2. Specimen Processing: From Gross Specimens to Tissue Cassettes

3. The Histology Laboratory

4. The Surgical Pathology Report

5. Consultation Reports

6. Operating Room Consultations

7. Special Studies

8. Safety Precautions

9. Microscopy and Photography

10. Adrenal Glands

11. Amputations and Large Resections

12. Biopsies, Small

13. Bones and Joints

14. Breast

15. Bullets

16. Cardiovascular Specimens

17. Cytology Specimens

18. Dermatopathology

19. Gastrointestinal, Hepatobiliary, and Pancreatic Specimens

20. Genitourinary Specimens

21. Gross Examination

22. Gynecologic and Perinatal Pathology

23. Head and Neck

24. Hernia Sac

25. Larynx

26. Lung and Pleura

27. Lymph Nodes, Spleen, and Bone Marrow

28. Medical Devices and Foreign Materials

29. Neuropathology

30. Paraganglioma

31. Penis

32. Soft issue Tumors (Sarcomas)

33. Thymus

34. Thyroid and Parathyroid Glands

35. Frequent Errors and Pitfalls in Specimen Processing


No. of pages:
© 2006
eBook ISBN:
Print ISBN:

About the author

Susan Lester

Affiliations and Expertise

Chief, Breast Pathology Services, Brigham and Women’s Hospital; Assistant Professor, Harvard Medical School, Staff Pathologist, Dana Farber Cancer Institute, Boston, Massachusetts, USA


"This book, especially with its reasonable price, is a must for every surgical lab. Moreover, it is an excellent reference book full of information that is otherwise hard to find, but which every pathologist would like within easy reach at certain critical moments."-International Journal of Gynecologic Pathology

"The first edition (2000) grew out of a procedure manual prepared at the Brigham and Women’s Hospital—a collaborative effort involving the expertise of staff, residents, and assistants; the handbook has evolved at that institution over the years, and pathologist Susan Lester undertook preparation of this second edition. In her preface she specifies that the manual is intended as a guide rather than a prescription, because cases and procedures vary from institution to institution. Coverage includes
step-by-step instruction for the gross examination and processing of pathology spcimens, check lists for each major tumor type, current recommended criteria for tumor grading, discussions of frozen section diagnosis, injury prevention, and basic microscopic techniques. Approximately 150 tables support the text." -- SciTech Book News, March 2006